Immunohistochemical analysis of NaPi2b protein (MX35 antigen) expression and subcellular localization in human normal and cancer tissues

Immunohistochemical analysis of NaPi2b protein (MX35 antigen) expression and subcellular localization in human normal and cancer tissues

Aim: To study the expression profile of the NaPi2b protein and its localization in breast, ovarian and lung cancer cells in relation to normal tissues adjacent to tumor. Methods: Immunohistochemical analysis with monoclonal antibody MX35 was applied for investigation of NaPi2b protein expression in...

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Бібліографічні деталі
Опубліковано в: :Experimental Oncology
Дата:2011
Автори: Kiyamova, R., Shyian, M., Lyzogubov, V.V., Usenko, V.S., Gout, T., Filonenko, V.
Формат: Стаття
Мова:English
Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2011
Теми:
Original contributions
Онлайн доступ:https://nasplib.isofts.kiev.ua/handle/123456789/138654
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Цитувати:Immunohistochemical analysis of NaPi2b protein (MX35 antigen) expression and subcellular localization in human normal and cancer tissues / R. Kiyamova, M. Shyian, V.V. Lyzogubov, V.S. Usenko, T. Gout, V. Filonenko // Experimental Oncology. — 2011. — Т. 33, № 3. — С. 157-161. — Бібліогр.: 23 назв. — англ.

Репозитарії

Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-138654
record_format dspace
spelling Kiyamova, R.
Shyian, M.
Lyzogubov, V.V.
Usenko, V.S.
Gout, T.
Filonenko, V.
2018-06-19T10:56:47Z
2018-06-19T10:56:47Z
2011
Immunohistochemical analysis of NaPi2b protein (MX35 antigen) expression and subcellular localization in human normal and cancer tissues / R. Kiyamova, M. Shyian, V.V. Lyzogubov, V.S. Usenko, T. Gout, V. Filonenko // Experimental Oncology. — 2011. — Т. 33, № 3. — С. 157-161. — Бібліогр.: 23 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/138654
Aim: To study the expression profile of the NaPi2b protein and its localization in breast, ovarian and lung cancer cells in relation to normal tissues adjacent to tumor. Methods: Immunohistochemical analysis with monoclonal antibody MX35 was applied for investigation of NaPi2b protein expression in breast, lung and ovarian carcinomas. Intensity of NaPi2b protein expression was calculated with semiquantitative scores. Results: NaPi2b (MX35) protein expression was detected in breast, lung and ovarian cancer cells and adjacent normal tissue. We have shown that in contrast to ovarian tumors in breast and lung tumors NaPi2b expression is down regulated comparing to correspondent normal tissues. Conclusion: This study provides the data on the pattern of NaPi2b expression and cellular localization in breast, lung and ovarian cancers, which might be useful for understanding the mechanism of transport and maintenance of inorganic phosphate in cancer and normal cells, as well as for developing novel immunotherapeutic approaches based on MX35 monoclonal antibody.
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Original contributions
Immunohistochemical analysis of NaPi2b protein (MX35 antigen) expression and subcellular localization in human normal and cancer tissues
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title Immunohistochemical analysis of NaPi2b protein (MX35 antigen) expression and subcellular localization in human normal and cancer tissues
spellingShingle Immunohistochemical analysis of NaPi2b protein (MX35 antigen) expression and subcellular localization in human normal and cancer tissues
Kiyamova, R.
Shyian, M.
Lyzogubov, V.V.
Usenko, V.S.
Gout, T.
Filonenko, V.
Original contributions
title_short Immunohistochemical analysis of NaPi2b protein (MX35 antigen) expression and subcellular localization in human normal and cancer tissues
title_full Immunohistochemical analysis of NaPi2b protein (MX35 antigen) expression and subcellular localization in human normal and cancer tissues
title_fullStr Immunohistochemical analysis of NaPi2b protein (MX35 antigen) expression and subcellular localization in human normal and cancer tissues
title_full_unstemmed Immunohistochemical analysis of NaPi2b protein (MX35 antigen) expression and subcellular localization in human normal and cancer tissues
title_sort immunohistochemical analysis of napi2b protein (mx35 antigen) expression and subcellular localization in human normal and cancer tissues
author Kiyamova, R.
Shyian, M.
Lyzogubov, V.V.
Usenko, V.S.
Gout, T.
Filonenko, V.
author_facet Kiyamova, R.
Shyian, M.
Lyzogubov, V.V.
Usenko, V.S.
Gout, T.
Filonenko, V.
topic Original contributions
topic_facet Original contributions
publishDate 2011
language English
container_title Experimental Oncology
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
format Article
description Aim: To study the expression profile of the NaPi2b protein and its localization in breast, ovarian and lung cancer cells in relation to normal tissues adjacent to tumor. Methods: Immunohistochemical analysis with monoclonal antibody MX35 was applied for investigation of NaPi2b protein expression in breast, lung and ovarian carcinomas. Intensity of NaPi2b protein expression was calculated with semiquantitative scores. Results: NaPi2b (MX35) protein expression was detected in breast, lung and ovarian cancer cells and adjacent normal tissue. We have shown that in contrast to ovarian tumors in breast and lung tumors NaPi2b expression is down regulated comparing to correspondent normal tissues. Conclusion: This study provides the data on the pattern of NaPi2b expression and cellular localization in breast, lung and ovarian cancers, which might be useful for understanding the mechanism of transport and maintenance of inorganic phosphate in cancer and normal cells, as well as for developing novel immunotherapeutic approaches based on MX35 monoclonal antibody.
issn 1812-9269
url https://nasplib.isofts.kiev.ua/handle/123456789/138654
citation_txt Immunohistochemical analysis of NaPi2b protein (MX35 antigen) expression and subcellular localization in human normal and cancer tissues / R. Kiyamova, M. Shyian, V.V. Lyzogubov, V.S. Usenko, T. Gout, V. Filonenko // Experimental Oncology. — 2011. — Т. 33, № 3. — С. 157-161. — Бібліогр.: 23 назв. — англ.
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AT lyzogubovvv immunohistochemicalanalysisofnapi2bproteinmx35antigenexpressionandsubcellularlocalizationinhumannormalandcancertissues
AT usenkovs immunohistochemicalanalysisofnapi2bproteinmx35antigenexpressionandsubcellularlocalizationinhumannormalandcancertissues
AT goutt immunohistochemicalanalysisofnapi2bproteinmx35antigenexpressionandsubcellularlocalizationinhumannormalandcancertissues
AT filonenkov immunohistochemicalanalysisofnapi2bproteinmx35antigenexpressionandsubcellularlocalizationinhumannormalandcancertissues
first_indexed 2025-12-07T19:32:10Z
last_indexed 2025-12-07T19:32:10Z
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