Association of polymorphic G1934A variant (allele *4) of CYP2D6 gene with increased risk of breast cancer development in Ukrainian women

Association of polymorphic G1934A variant (allele *4) of CYP2D6 gene with increased risk of breast cancer development in Ukrainian women

Institute of Genetic and Regenerative Medicine of the Ukrainian Academy of Medical Sciences”, Kiev, 03150, UkraineBackground: Breast cancer (BC) is among the most common oncologic pathology in economically developed countries where it afflicts nearly 10% of women. Polymorphism of CYP 2D6 gene is sho...

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Published in:Experimental Oncology
Date:2011
Main Authors: Levkovich, N.N., Gorovenko, N.G., Myasoedov, D.V.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2011
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Online Access:https://nasplib.isofts.kiev.ua/handle/123456789/138655
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Journal Title:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Cite this:Association of polymorphic G1934A variant (allele *4) of CYP2D6 gene with increased risk of breast cancer development in Ukrainian women / N.N. Levkovich, N.G. Gorovenko, D.V. Myasoedov // Experimental Oncology. — 2011. — Т. 33, № 3. — С. 136-139. — Бібліогр.: 15 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-138655
record_format dspace
spelling Levkovich, N.N.
Gorovenko, N.G.
Myasoedov, D.V.
2018-06-19T10:57:33Z
2018-06-19T10:57:33Z
2011
Association of polymorphic G1934A variant (allele *4) of CYP2D6 gene with increased risk of breast cancer development in Ukrainian women / N.N. Levkovich, N.G. Gorovenko, D.V. Myasoedov // Experimental Oncology. — 2011. — Т. 33, № 3. — С. 136-139. — Бібліогр.: 15 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/138655
Institute of Genetic and Regenerative Medicine of the Ukrainian Academy of Medical Sciences”, Kiev, 03150, UkraineBackground: Breast cancer (BC) is among the most common oncologic pathology in economically developed countries where it afflicts nearly 10% of women. Polymorphism of CYP 2D6 gene is shown to be associated with increased risk of development of a number of pathologies, in particular cancer. Aim: The work was directed on evaluation of the role of polymorphism G1934A (allele *4) of CYP 2D6 gene in elevated risk of BC development in Ukrainian women. Materials and Methods: In the study there were enrolled 85 patients (group І) with histologically verified BC diagnosis of stages I and ІІ. Clinical-genealogic study has been performed by the method of patient survey and following analysis of genealogy. Earlier obtained data on the frequency of genotypes and alleles of CYP 2D6 gene in 637 Ukrainian people have been used as a control. For determination of allele variant *4 (G1934A) of CYP 2D6 gene the method of PCR-RFLP has been used. Results: An increased risk of BC development in hereditary tainted patients with genotype *4*4 of CYP 2D6 gene compared to the control group has been revealed. The frequency of *1*4 (IM) genotype has been found to be increased in the group of women with a family history of cancer (41.79%). Significant difference between the frequency of *1*1 (ЕМ) and *1*4 (ІМ) genotypes in females with PR-positive and PR-negative tumors in the group of hereditary tainted patients has been registered. Conclusion: In conclusion, our study has revealed an increased risk of BC development in hereditary tainted patients compared to control group with genotype *4*4 (РМ).
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Original contributions
Association of polymorphic G1934A variant (allele *4) of CYP2D6 gene with increased risk of breast cancer development in Ukrainian women
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title Association of polymorphic G1934A variant (allele *4) of CYP2D6 gene with increased risk of breast cancer development in Ukrainian women
spellingShingle Association of polymorphic G1934A variant (allele *4) of CYP2D6 gene with increased risk of breast cancer development in Ukrainian women
Levkovich, N.N.
Gorovenko, N.G.
Myasoedov, D.V.
Original contributions
title_short Association of polymorphic G1934A variant (allele *4) of CYP2D6 gene with increased risk of breast cancer development in Ukrainian women
title_full Association of polymorphic G1934A variant (allele *4) of CYP2D6 gene with increased risk of breast cancer development in Ukrainian women
title_fullStr Association of polymorphic G1934A variant (allele *4) of CYP2D6 gene with increased risk of breast cancer development in Ukrainian women
title_full_unstemmed Association of polymorphic G1934A variant (allele *4) of CYP2D6 gene with increased risk of breast cancer development in Ukrainian women
title_sort association of polymorphic g1934a variant (allele *4) of cyp2d6 gene with increased risk of breast cancer development in ukrainian women
author Levkovich, N.N.
Gorovenko, N.G.
Myasoedov, D.V.
author_facet Levkovich, N.N.
Gorovenko, N.G.
Myasoedov, D.V.
topic Original contributions
topic_facet Original contributions
publishDate 2011
language English
container_title Experimental Oncology
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
format Article
description Institute of Genetic and Regenerative Medicine of the Ukrainian Academy of Medical Sciences”, Kiev, 03150, UkraineBackground: Breast cancer (BC) is among the most common oncologic pathology in economically developed countries where it afflicts nearly 10% of women. Polymorphism of CYP 2D6 gene is shown to be associated with increased risk of development of a number of pathologies, in particular cancer. Aim: The work was directed on evaluation of the role of polymorphism G1934A (allele *4) of CYP 2D6 gene in elevated risk of BC development in Ukrainian women. Materials and Methods: In the study there were enrolled 85 patients (group І) with histologically verified BC diagnosis of stages I and ІІ. Clinical-genealogic study has been performed by the method of patient survey and following analysis of genealogy. Earlier obtained data on the frequency of genotypes and alleles of CYP 2D6 gene in 637 Ukrainian people have been used as a control. For determination of allele variant *4 (G1934A) of CYP 2D6 gene the method of PCR-RFLP has been used. Results: An increased risk of BC development in hereditary tainted patients with genotype *4*4 of CYP 2D6 gene compared to the control group has been revealed. The frequency of *1*4 (IM) genotype has been found to be increased in the group of women with a family history of cancer (41.79%). Significant difference between the frequency of *1*1 (ЕМ) and *1*4 (ІМ) genotypes in females with PR-positive and PR-negative tumors in the group of hereditary tainted patients has been registered. Conclusion: In conclusion, our study has revealed an increased risk of BC development in hereditary tainted patients compared to control group with genotype *4*4 (РМ).
issn 1812-9269
url https://nasplib.isofts.kiev.ua/handle/123456789/138655
citation_txt Association of polymorphic G1934A variant (allele *4) of CYP2D6 gene with increased risk of breast cancer development in Ukrainian women / N.N. Levkovich, N.G. Gorovenko, D.V. Myasoedov // Experimental Oncology. — 2011. — Т. 33, № 3. — С. 136-139. — Бібліогр.: 15 назв. — англ.
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AT gorovenkong associationofpolymorphicg1934avariantallele4ofcyp2d6genewithincreasedriskofbreastcancerdevelopmentinukrainianwomen
AT myasoedovdv associationofpolymorphicg1934avariantallele4ofcyp2d6genewithincreasedriskofbreastcancerdevelopmentinukrainianwomen
first_indexed 2025-12-01T13:57:45Z
last_indexed 2025-12-01T13:57:45Z
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