Effect of vasopressin V1b receptor antagonist, SSR149415, on anxiety-like behavior and lewis lung carcinoma metastasis in mice
Aim: To study the effect of new vasopressin V1b receptor antagonist, SSR149415, on anxiety-like behavior and Lewis lung carcinoma metastasis in the anxious adult male mice of C57Bl/6J strain. This type of receptors was thought to act as potential targets mediating the effect of negative psychoemotio...
Saved in:
| Published in: | Experimental Oncology |
|---|---|
| Date: | 2011 |
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Published: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2011
|
| Subjects: | |
| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/138660 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Effect of vasopressin V1b receptor antagonist, SSR149415, on anxiety-like behavior and lewis lung carcinoma metastasis in mice / A.V. Amikishieva, S.I. Ilnitskaya, V.P. Nikolin, N.A. Popova // Experimental Oncology. — 2011. — Т. 33, № 3. — С. 126-129. — Бібліогр.: 25 назв. — англ. |
Institution
Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862538091218075648 |
|---|---|
| author | Amikishieva, A.V. Ilnitskaya, S.I. Nikolin, V.P. Popova, N.A. |
| author_facet | Amikishieva, A.V. Ilnitskaya, S.I. Nikolin, V.P. Popova, N.A. |
| citation_txt | Effect of vasopressin V1b receptor antagonist, SSR149415, on anxiety-like behavior and lewis lung carcinoma metastasis in mice / A.V. Amikishieva, S.I. Ilnitskaya, V.P. Nikolin, N.A. Popova // Experimental Oncology. — 2011. — Т. 33, № 3. — С. 126-129. — Бібліогр.: 25 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Aim: To study the effect of new vasopressin V1b receptor antagonist, SSR149415, on anxiety-like behavior and Lewis lung carcinoma metastasis in the anxious adult male mice of C57Bl/6J strain. This type of receptors was thought to act as potential targets mediating the effect of negative psychoemotional state on tumor progression. Methods: Anxiety-like psychoemotional state of the animals was produced using chronic social conflict model. Used behavioral tests were elevated plus-maze, social interaction test and open field test. Tumor cells were administrated on background of double or sixfold SSR149415 injections and the number of metastases in the lung were calculated 17 days later. Results: SSR149415 reduced the anxiety-like behavior measured in the elevated plus-maze and social interaction tests and did not affect locomotor activity in the open field test. Double and sixfold administration of the compound to such mice before and after inoculation of the tumor cells produced no effect on the metastasis rate. Conclusion: vasopressin V1b receptor is involved in the mediation of anxious behavior of animals but is not involved in the mechanism underlying the influence of negative psychoemotional state on Lewis lung carcinoma metastasis.
|
| first_indexed | 2025-11-24T12:45:37Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-138660 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-11-24T12:45:37Z |
| publishDate | 2011 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Amikishieva, A.V. Ilnitskaya, S.I. Nikolin, V.P. Popova, N.A. 2018-06-19T11:08:41Z 2018-06-19T11:08:41Z 2011 Effect of vasopressin V1b receptor antagonist, SSR149415, on anxiety-like behavior and lewis lung carcinoma metastasis in mice / A.V. Amikishieva, S.I. Ilnitskaya, V.P. Nikolin, N.A. Popova // Experimental Oncology. — 2011. — Т. 33, № 3. — С. 126-129. — Бібліогр.: 25 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/138660 Aim: To study the effect of new vasopressin V1b receptor antagonist, SSR149415, on anxiety-like behavior and Lewis lung carcinoma metastasis in the anxious adult male mice of C57Bl/6J strain. This type of receptors was thought to act as potential targets mediating the effect of negative psychoemotional state on tumor progression. Methods: Anxiety-like psychoemotional state of the animals was produced using chronic social conflict model. Used behavioral tests were elevated plus-maze, social interaction test and open field test. Tumor cells were administrated on background of double or sixfold SSR149415 injections and the number of metastases in the lung were calculated 17 days later. Results: SSR149415 reduced the anxiety-like behavior measured in the elevated plus-maze and social interaction tests and did not affect locomotor activity in the open field test. Double and sixfold administration of the compound to such mice before and after inoculation of the tumor cells produced no effect on the metastasis rate. Conclusion: vasopressin V1b receptor is involved in the mediation of anxious behavior of animals but is not involved in the mechanism underlying the influence of negative psychoemotional state on Lewis lung carcinoma metastasis. The authors are grateful to Dr. Claudine SerradeilLe Gal (Sanofi Eventis Recherche & Developpement, France) for kind provision of V1b receptor antagonist. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Effect of vasopressin V1b receptor antagonist, SSR149415, on anxiety-like behavior and lewis lung carcinoma metastasis in mice Article published earlier |
| spellingShingle | Effect of vasopressin V1b receptor antagonist, SSR149415, on anxiety-like behavior and lewis lung carcinoma metastasis in mice Amikishieva, A.V. Ilnitskaya, S.I. Nikolin, V.P. Popova, N.A. Original contributions |
| title | Effect of vasopressin V1b receptor antagonist, SSR149415, on anxiety-like behavior and lewis lung carcinoma metastasis in mice |
| title_full | Effect of vasopressin V1b receptor antagonist, SSR149415, on anxiety-like behavior and lewis lung carcinoma metastasis in mice |
| title_fullStr | Effect of vasopressin V1b receptor antagonist, SSR149415, on anxiety-like behavior and lewis lung carcinoma metastasis in mice |
| title_full_unstemmed | Effect of vasopressin V1b receptor antagonist, SSR149415, on anxiety-like behavior and lewis lung carcinoma metastasis in mice |
| title_short | Effect of vasopressin V1b receptor antagonist, SSR149415, on anxiety-like behavior and lewis lung carcinoma metastasis in mice |
| title_sort | effect of vasopressin v1b receptor antagonist, ssr149415, on anxiety-like behavior and lewis lung carcinoma metastasis in mice |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/138660 |
| work_keys_str_mv | AT amikishievaav effectofvasopressinv1breceptorantagonistssr149415onanxietylikebehaviorandlewislungcarcinomametastasisinmice AT ilnitskayasi effectofvasopressinv1breceptorantagonistssr149415onanxietylikebehaviorandlewislungcarcinomametastasisinmice AT nikolinvp effectofvasopressinv1breceptorantagonistssr149415onanxietylikebehaviorandlewislungcarcinomametastasisinmice AT popovana effectofvasopressinv1breceptorantagonistssr149415onanxietylikebehaviorandlewislungcarcinomametastasisinmice |