Mobile genetic elements and cancer. From mutations to gene therapy
In the present review, an association between cancer and the activity of the non-LTR retroelements L1, Alu, and SVA, as well as endogenous retroviruses, in the human genome, is analyzed. Data suggesting that transposons have been involved in embryogenesis and malignization processes, are presented....
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| Veröffentlicht in: | Experimental Oncology |
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| Datum: | 2011 |
| ISSN: | 1812-9269 |
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | Englisch |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2011
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| Online Zugang: | https://nasplib.isofts.kiev.ua/handle/123456789/138667 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Zitieren: | Mobile genetic elements and cancer. From mutations to gene therapy / I.A. Kozeretska, S.V. Demydov, L.I. Ostapchenko // Experimental Oncology. — 2011. — Т. 33, № 4. — С. 198-205. — Бібліогр.: 114 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| Zusammenfassung: | In the present review, an association between cancer and the activity of the non-LTR retroelements L1, Alu, and SVA, as well as endogenous retroviruses, in the human genome, is analyzed. Data suggesting that transposons have been involved in embryogenesis and malignization processes, are presented. Events that lead to the activation of mobile elements in mammalian somatic cells, as well as the use of mobile elements in genetic screening and cancer gene therapy, are reviewed.
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| ISSN: | 1812-9269 |