Ascorbate depletion increases growth and metastasis of melanoma cells in vitamin C deficient mice

• Published in: Experimental Oncology
• Date: 2011
• Main Authors: Cha, J., Roomi, M.W., Ivanov, V., Kalinovsky, T., Niedzwiecki, A., Rath, M.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2011
• Subjects: Original contributions
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/138671
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Ascorbate depletion increases growth and metastasis of melanoma cells in vitamin C deficient mice / J. Cha, M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath // Experimental Oncology. — 2011. — Т. 33, № 4. — С. 226-230. — Бібліогр.: 20 назв. — англ.

Aim: Our main objective was to determine the effect of ascorbate supplementation in mice unable to synthesize ascorbic acid (gulo KO) when challenged with murine B16FO cancer cells. Methods: Gulo KO female mice 36–40 weeks of age were deprived of or maintained on ascorbate in food and water for 4 we...