Depressive-like psychoemotional state versus acute stresses enhances Lewis lung carcinoma metastasis in C57BL/6J mice

Depressive-like psychoemotional state versus acute stresses enhances Lewis lung carcinoma metastasis in C57BL/6J mice

Aim: The effect of a depression-like status formed by chronic stress on the development of Lewis lung carcinoma metastases in C57Bl/6J mice was investigated. Two types of acute stress (restraint and social stress) were used for comparison. Methods: The depression-like status was induced by eight-wee...

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Veröffentlicht in:Experimental Oncology
Datum:2011
Hauptverfasser: Amikishieva, A.V., Ilnitskaya, S.I., Nikolin, V.P., Popova, N.A., Kaledin, V.I.
Format: Artikel
Sprache:English
Veröffentlicht: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2011
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Original contributions
Online Zugang:https://nasplib.isofts.kiev.ua/handle/123456789/138673
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Zitieren:Depressive-like psychoemotional state versus acute stresses enhances Lewis lung carcinoma metastasis in C57BL/6J mice / A.V. Amikishieva, S.I. Ilnitskaya, V.P. Nikolin, N.A. Popova, V.I. Kaledin // Experimental Oncology. — 2011. — Т. 33, № 4. — С. 222-225. — Бібліогр.: 23 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-138673
record_format dspace
spelling Amikishieva, A.V.
Ilnitskaya, S.I.
Nikolin, V.P.
Popova, N.A.
Kaledin, V.I.
2018-06-19T11:24:24Z
2018-06-19T11:24:24Z
2011
Depressive-like psychoemotional state versus acute stresses enhances Lewis lung carcinoma metastasis in C57BL/6J mice / A.V. Amikishieva, S.I. Ilnitskaya, V.P. Nikolin, N.A. Popova, V.I. Kaledin // Experimental Oncology. — 2011. — Т. 33, № 4. — С. 222-225. — Бібліогр.: 23 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/138673
Aim: The effect of a depression-like status formed by chronic stress on the development of Lewis lung carcinoma metastases in C57Bl/6J mice was investigated. Two types of acute stress (restraint and social stress) were used for comparison. Methods: The depression-like status was induced by eight-week exposure to repeated but unpredictable stressors (chronic mild stress model) and was assessed in the forced swim test. Tumor cells were inoculated an hour after the onset of social stressor or immediately after physical or chronic stressor impacts. The number of metastases was counted 17 days after the inoculation. Results: Chronic mild stress provokes the development of a depression-like state in mice and causes a twofold increase in the number of metastases in the lungs, while both types of acute stress have no such effects. Conclusion: Depressive-like psychoemotional state of animals enhances the metastasis of Lewis lung carcinoma.
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Original contributions
Depressive-like psychoemotional state versus acute stresses enhances Lewis lung carcinoma metastasis in C57BL/6J mice
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title Depressive-like psychoemotional state versus acute stresses enhances Lewis lung carcinoma metastasis in C57BL/6J mice
spellingShingle Depressive-like psychoemotional state versus acute stresses enhances Lewis lung carcinoma metastasis in C57BL/6J mice
Amikishieva, A.V.
Ilnitskaya, S.I.
Nikolin, V.P.
Popova, N.A.
Kaledin, V.I.
Original contributions
title_short Depressive-like psychoemotional state versus acute stresses enhances Lewis lung carcinoma metastasis in C57BL/6J mice
title_full Depressive-like psychoemotional state versus acute stresses enhances Lewis lung carcinoma metastasis in C57BL/6J mice
title_fullStr Depressive-like psychoemotional state versus acute stresses enhances Lewis lung carcinoma metastasis in C57BL/6J mice
title_full_unstemmed Depressive-like psychoemotional state versus acute stresses enhances Lewis lung carcinoma metastasis in C57BL/6J mice
title_sort depressive-like psychoemotional state versus acute stresses enhances lewis lung carcinoma metastasis in c57bl/6j mice
author Amikishieva, A.V.
Ilnitskaya, S.I.
Nikolin, V.P.
Popova, N.A.
Kaledin, V.I.
author_facet Amikishieva, A.V.
Ilnitskaya, S.I.
Nikolin, V.P.
Popova, N.A.
Kaledin, V.I.
topic Original contributions
topic_facet Original contributions
publishDate 2011
language English
container_title Experimental Oncology
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
format Article
description Aim: The effect of a depression-like status formed by chronic stress on the development of Lewis lung carcinoma metastases in C57Bl/6J mice was investigated. Two types of acute stress (restraint and social stress) were used for comparison. Methods: The depression-like status was induced by eight-week exposure to repeated but unpredictable stressors (chronic mild stress model) and was assessed in the forced swim test. Tumor cells were inoculated an hour after the onset of social stressor or immediately after physical or chronic stressor impacts. The number of metastases was counted 17 days after the inoculation. Results: Chronic mild stress provokes the development of a depression-like state in mice and causes a twofold increase in the number of metastases in the lungs, while both types of acute stress have no such effects. Conclusion: Depressive-like psychoemotional state of animals enhances the metastasis of Lewis lung carcinoma.
issn 1812-9269
url https://nasplib.isofts.kiev.ua/handle/123456789/138673
citation_txt Depressive-like psychoemotional state versus acute stresses enhances Lewis lung carcinoma metastasis in C57BL/6J mice / A.V. Amikishieva, S.I. Ilnitskaya, V.P. Nikolin, N.A. Popova, V.I. Kaledin // Experimental Oncology. — 2011. — Т. 33, № 4. — С. 222-225. — Бібліогр.: 23 назв. — англ.
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AT nikolinvp depressivelikepsychoemotionalstateversusacutestressesenhanceslewislungcarcinomametastasisinc57bl6jmice
AT popovana depressivelikepsychoemotionalstateversusacutestressesenhanceslewislungcarcinomametastasisinc57bl6jmice
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first_indexed 2025-12-07T16:00:32Z
last_indexed 2025-12-07T16:00:32Z
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