The influence of sodium dichloroacetate on the oxidative processes in sarcoma 37
Aim: to study the activity of antioxidant enzymes and to evaluate an intensity of prooxidant processes in sarcoma 37 (S37) cells during tumor development and under influence of sodium dichloroacetate (SDA). Methods: Activity of total superoxide dismutase (SOD), SOD isoforms, catalase (Cat), glutathi...
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| Published in: | Experimental Oncology |
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| Date: | 2011 |
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2011
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/138675 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | The influence of sodium dichloroacetate on the oxidative processes in sarcoma 37 / L.V. Sorokina, T.V. Pyatchanina, G.V. Didenko, A.A. Kaplia, S.V. Khyzhnyak // Experimental Oncology. — 2011. — Т. 33, № 4. — С. 216-221. — Бібліогр.: 21 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862550659091398656 |
|---|---|
| author | Sorokina, L.V. Pyatchanina, T.V. Didenko, G.V. Kaplia, A.A. Khyzhnyak, S.V. |
| author_facet | Sorokina, L.V. Pyatchanina, T.V. Didenko, G.V. Kaplia, A.A. Khyzhnyak, S.V. |
| citation_txt | The influence of sodium dichloroacetate on the oxidative processes in sarcoma 37 / L.V. Sorokina, T.V. Pyatchanina, G.V. Didenko, A.A. Kaplia, S.V. Khyzhnyak // Experimental Oncology. — 2011. — Т. 33, № 4. — С. 216-221. — Бібліогр.: 21 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Aim: to study the activity of antioxidant enzymes and to evaluate an intensity of prooxidant processes in sarcoma 37 (S37) cells during tumor development and under influence of sodium dichloroacetate (SDA). Methods: Activity of total superoxide dismutase (SOD), SOD isoforms, catalase (Cat), glutathione peroxidase (GP), and glutathione reductase (GR), as well as content of reduced glutathione (GSH) and lipid peroxidation (LP) secondary byproducts were determined in S37 homogenated tissues of untreated mice and animals treated with SDA at daily dose of 86 mg/kg. Results: SDA treatment of S37-bearing mice resulted in the reduced activities of total SOD, SOD isoforms (especially Mn-SOD), Cat, GP and significantly decreased GSH content on the background of LP intensification in tumor tissue. Conclusion: The observed changes of oxidative homeostasis in S37-bearing animals treated with SDA could be considered as an element of antitumor action of SDA.
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| first_indexed | 2025-11-25T20:44:28Z |
| format | Article |
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| id | nasplib_isofts_kiev_ua-123456789-138675 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-11-25T20:44:28Z |
| publishDate | 2011 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
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| spelling | Sorokina, L.V. Pyatchanina, T.V. Didenko, G.V. Kaplia, A.A. Khyzhnyak, S.V. 2018-06-19T11:26:07Z 2018-06-19T11:26:07Z 2011 The influence of sodium dichloroacetate on the oxidative processes in sarcoma 37 / L.V. Sorokina, T.V. Pyatchanina, G.V. Didenko, A.A. Kaplia, S.V. Khyzhnyak // Experimental Oncology. — 2011. — Т. 33, № 4. — С. 216-221. — Бібліогр.: 21 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/138675 Aim: to study the activity of antioxidant enzymes and to evaluate an intensity of prooxidant processes in sarcoma 37 (S37) cells during tumor development and under influence of sodium dichloroacetate (SDA). Methods: Activity of total superoxide dismutase (SOD), SOD isoforms, catalase (Cat), glutathione peroxidase (GP), and glutathione reductase (GR), as well as content of reduced glutathione (GSH) and lipid peroxidation (LP) secondary byproducts were determined in S37 homogenated tissues of untreated mice and animals treated with SDA at daily dose of 86 mg/kg. Results: SDA treatment of S37-bearing mice resulted in the reduced activities of total SOD, SOD isoforms (especially Mn-SOD), Cat, GP and significantly decreased GSH content on the background of LP intensification in tumor tissue. Conclusion: The observed changes of oxidative homeostasis in S37-bearing animals treated with SDA could be considered as an element of antitumor action of SDA. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions The influence of sodium dichloroacetate on the oxidative processes in sarcoma 37 Article published earlier |
| spellingShingle | The influence of sodium dichloroacetate on the oxidative processes in sarcoma 37 Sorokina, L.V. Pyatchanina, T.V. Didenko, G.V. Kaplia, A.A. Khyzhnyak, S.V. Original contributions |
| title | The influence of sodium dichloroacetate on the oxidative processes in sarcoma 37 |
| title_full | The influence of sodium dichloroacetate on the oxidative processes in sarcoma 37 |
| title_fullStr | The influence of sodium dichloroacetate on the oxidative processes in sarcoma 37 |
| title_full_unstemmed | The influence of sodium dichloroacetate on the oxidative processes in sarcoma 37 |
| title_short | The influence of sodium dichloroacetate on the oxidative processes in sarcoma 37 |
| title_sort | influence of sodium dichloroacetate on the oxidative processes in sarcoma 37 |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/138675 |
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