Inhibition of TGFβ signaling and its implications in anticancer treatments

• Published in: Experimental Oncology
• Date: 2012
• ISSN: 1812-9269
• Main Authors: Calone, I., Souchelnytskyi, S.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2012
• Subjects: Reviews
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/138683
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Inhibition of TGFβ signaling and its implications in anticancer treatments / I. Calone, S. Souchelnytskyi // Experimental Oncology. — 2012. — Т. 34, № 1. — С. 9-16. — Бібліогр.: 95 назв. — англ.

The transforming growth factor-β (TGFβ) is a potent regulator of tumorigenesis. In cancer, two distinctive behaviors of TGFβ have been reported as a tumor suppressor at early stage of the disease, and as a tumor promoter at later stages. The past decades, the dualistic role of TGFβ has garnered a lo...