Chromosomal Radiosensitivity in Ukrainian breast cancer patients and healthy Individuals
Aim: Recent studies showed that increased chromosomal damage induced by ionizing radiation is observed among patients with different tumor types. The aim of the study was evaluation of chromosomal radiosensitivity in breast cancer (BC) patients (n = 37) and healthy women (n = 44). Methods: Chromosom...
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| Опубліковано в: : | Experimental Oncology |
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| Дата: | 2012 |
| Автори: | , , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2012
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| Онлайн доступ: | https://nasplib.isofts.kiev.ua/handle/123456789/138684 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Chromosomal Radiosensitivity in Ukrainian breast cancer patients and healthy Individuals / N.M. Ryabchenko, O.A. Glavin, V.V. Shtefura, M.F. Anikusko // Experimental Oncology. — 2012. — Т. 34, № 2. — С. 121-124. — Бібліогр.: 27 назв. — англ. |
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nasplib_isofts_kiev_ua-123456789-138684 |
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Ryabchenko, N.M. Glavin, O.A. Shtefura, V.V. Anikusko, M.F. 2018-06-19T11:37:58Z 2018-06-19T11:37:58Z 2012 Chromosomal Radiosensitivity in Ukrainian breast cancer patients and healthy Individuals / N.M. Ryabchenko, O.A. Glavin, V.V. Shtefura, M.F. Anikusko // Experimental Oncology. — 2012. — Т. 34, № 2. — С. 121-124. — Бібліогр.: 27 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/138684 Aim: Recent studies showed that increased chromosomal damage induced by ionizing radiation is observed among patients with different tumor types. The aim of the study was evaluation of chromosomal radiosensitivity in breast cancer (BC) patients (n = 37) and healthy women (n = 44). Methods: Chromosomal radiosensitivity was assessed with G0 and G2 assay. For G0 assay lymphocytes were exposed in vitro to 1,5 Gy of X-rays before culture setting. For G2 assay lymphocytes were irradiated with 0,5 Gy of X-rays after 47 h of incubation. Results: Significant differences in mean scores both of G0 and G2 assay between breast cancer patients and controls were observed indicating the increased chromosomal radiosensitivity of lymphocytes of cancer patients. 11% of healthy women and 38% of BC patients were determined to be radiosensitive with G2 assay. Conclusion: Obtained results support the concept of association between elevated individual G2 chromosomal radiosensitivity and predisposition to BC. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Chromosomal Radiosensitivity in Ukrainian breast cancer patients and healthy Individuals Article published earlier |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| title |
Chromosomal Radiosensitivity in Ukrainian breast cancer patients and healthy Individuals |
| spellingShingle |
Chromosomal Radiosensitivity in Ukrainian breast cancer patients and healthy Individuals Ryabchenko, N.M. Glavin, O.A. Shtefura, V.V. Anikusko, M.F. Original contributions |
| title_short |
Chromosomal Radiosensitivity in Ukrainian breast cancer patients and healthy Individuals |
| title_full |
Chromosomal Radiosensitivity in Ukrainian breast cancer patients and healthy Individuals |
| title_fullStr |
Chromosomal Radiosensitivity in Ukrainian breast cancer patients and healthy Individuals |
| title_full_unstemmed |
Chromosomal Radiosensitivity in Ukrainian breast cancer patients and healthy Individuals |
| title_sort |
chromosomal radiosensitivity in ukrainian breast cancer patients and healthy individuals |
| author |
Ryabchenko, N.M. Glavin, O.A. Shtefura, V.V. Anikusko, M.F. |
| author_facet |
Ryabchenko, N.M. Glavin, O.A. Shtefura, V.V. Anikusko, M.F. |
| topic |
Original contributions |
| topic_facet |
Original contributions |
| publishDate |
2012 |
| language |
English |
| container_title |
Experimental Oncology |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| format |
Article |
| description |
Aim: Recent studies showed that increased chromosomal damage induced by ionizing radiation is observed among patients with different tumor types. The aim of the study was evaluation of chromosomal radiosensitivity in breast cancer (BC) patients (n = 37) and healthy women (n = 44). Methods: Chromosomal radiosensitivity was assessed with G0 and G2 assay. For G0 assay lymphocytes were exposed in vitro to 1,5 Gy of X-rays before culture setting. For G2 assay lymphocytes were irradiated with 0,5 Gy of X-rays after 47 h of incubation. Results: Significant differences in mean scores both of G0 and G2 assay between breast cancer patients and controls were observed indicating the increased chromosomal radiosensitivity of lymphocytes of cancer patients. 11% of healthy women and 38% of BC patients were determined to be radiosensitive with G2 assay. Conclusion: Obtained results support the concept of association between elevated individual G2 chromosomal radiosensitivity and predisposition to BC.
|
| issn |
1812-9269 |
| url |
https://nasplib.isofts.kiev.ua/handle/123456789/138684 |
| citation_txt |
Chromosomal Radiosensitivity in Ukrainian breast cancer patients and healthy Individuals / N.M. Ryabchenko, O.A. Glavin, V.V. Shtefura, M.F. Anikusko // Experimental Oncology. — 2012. — Т. 34, № 2. — С. 121-124. — Бібліогр.: 27 назв. — англ. |
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