Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells

Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells

The aim of this research is to study the dynamics and efficiency of liposome accumulation in sensitive and resistant human breast cancer cells. Methods: Methods of fluorescence microscopy, fluorescence microspectroscopy and MTT-test have been used. Results: The liposome-to-cell interaction and dye c...

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Published in:Experimental Oncology
Date:2012
Main Authors: Yefimova, S.L., Kurilchenko, I.Yu., Tkacheva, T.N., Rozhkov, V.A., Sorokin, A.V., Lukianova, N.Yu., Bezdenezhnykh, N.A., Malyukin, Yu.V., Chekhun, V.F.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2012
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Original contributions
Online Access:https://nasplib.isofts.kiev.ua/handle/123456789/138691
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Journal Title:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Cite this:Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells / S.L. Yefimova, I.Yu. Kurilchenko, T.N. Tkacheva, V.A. Rozhkov, A.V. Sorokin, N.Yu. Lukianova, N.A. Bezdenezhnykh, Yu.V. Malyukin, V.F. Chekhun // Experimental Oncology. — 2012. — Т. 34, № 2. — С. 101-106. — Бібліогр.: 14 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-138691
record_format dspace
spelling Yefimova, S.L.
Kurilchenko, I.Yu.
Tkacheva, T.N.
Rozhkov, V.A.
Sorokin, A.V.
Lukianova, N.Yu.
Bezdenezhnykh, N.A.
Malyukin, Yu.V.
Chekhun, V.F.
2018-06-19T11:43:19Z
2018-06-19T11:43:19Z
2012
Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells / S.L. Yefimova, I.Yu. Kurilchenko, T.N. Tkacheva, V.A. Rozhkov, A.V. Sorokin, N.Yu. Lukianova, N.A. Bezdenezhnykh, Yu.V. Malyukin, V.F. Chekhun // Experimental Oncology. — 2012. — Т. 34, № 2. — С. 101-106. — Бібліогр.: 14 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/138691
The aim of this research is to study the dynamics and efficiency of liposome accumulation in sensitive and resistant human breast cancer cells. Methods: Methods of fluorescence microscopy, fluorescence microspectroscopy and MTT-test have been used. Results: The liposome-to-cell interaction and dye cellular uptake in sensitive, cisplatin-resistant and doxorubicin-resistant MCF-7 human breast cancer cells have been analyzed using time changes in both fluorescence resonance energy transfer signal from the donor probe DiO to the acceptor one DiI preloaded in liposomes and cell image brightness. Conclusion: Obtained results show that resistant cells accumulate dye-loaded liposomes more effectively and reveal more effective dye molecule cellular uptake.
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Original contributions
Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells
spellingShingle Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells
Yefimova, S.L.
Kurilchenko, I.Yu.
Tkacheva, T.N.
Rozhkov, V.A.
Sorokin, A.V.
Lukianova, N.Yu.
Bezdenezhnykh, N.A.
Malyukin, Yu.V.
Chekhun, V.F.
Original contributions
title_short Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells
title_full Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells
title_fullStr Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells
title_full_unstemmed Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells
title_sort comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells
author Yefimova, S.L.
Kurilchenko, I.Yu.
Tkacheva, T.N.
Rozhkov, V.A.
Sorokin, A.V.
Lukianova, N.Yu.
Bezdenezhnykh, N.A.
Malyukin, Yu.V.
Chekhun, V.F.
author_facet Yefimova, S.L.
Kurilchenko, I.Yu.
Tkacheva, T.N.
Rozhkov, V.A.
Sorokin, A.V.
Lukianova, N.Yu.
Bezdenezhnykh, N.A.
Malyukin, Yu.V.
Chekhun, V.F.
topic Original contributions
topic_facet Original contributions
publishDate 2012
language English
container_title Experimental Oncology
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
format Article
description The aim of this research is to study the dynamics and efficiency of liposome accumulation in sensitive and resistant human breast cancer cells. Methods: Methods of fluorescence microscopy, fluorescence microspectroscopy and MTT-test have been used. Results: The liposome-to-cell interaction and dye cellular uptake in sensitive, cisplatin-resistant and doxorubicin-resistant MCF-7 human breast cancer cells have been analyzed using time changes in both fluorescence resonance energy transfer signal from the donor probe DiO to the acceptor one DiI preloaded in liposomes and cell image brightness. Conclusion: Obtained results show that resistant cells accumulate dye-loaded liposomes more effectively and reveal more effective dye molecule cellular uptake.
issn 1812-9269
url https://nasplib.isofts.kiev.ua/handle/123456789/138691
citation_txt Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells / S.L. Yefimova, I.Yu. Kurilchenko, T.N. Tkacheva, V.A. Rozhkov, A.V. Sorokin, N.Yu. Lukianova, N.A. Bezdenezhnykh, Yu.V. Malyukin, V.F. Chekhun // Experimental Oncology. — 2012. — Т. 34, № 2. — С. 101-106. — Бібліогр.: 14 назв. — англ.
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first_indexed 2025-12-07T21:16:54Z
last_indexed 2025-12-07T21:16:54Z
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