Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells
The aim of this research is to study the dynamics and efficiency of liposome accumulation in sensitive and resistant human breast cancer cells. Methods: Methods of fluorescence microscopy, fluorescence microspectroscopy and MTT-test have been used. Results: The liposome-to-cell interaction and dye c...
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| Veröffentlicht in: | Experimental Oncology |
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| Datum: | 2012 |
| Hauptverfasser: | , , , , , , , , |
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| Sprache: | Englisch |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2012
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| Online Zugang: | https://nasplib.isofts.kiev.ua/handle/123456789/138691 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Zitieren: | Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells / S.L. Yefimova, I.Yu. Kurilchenko, T.N. Tkacheva, V.A. Rozhkov, A.V. Sorokin, N.Yu. Lukianova, N.A. Bezdenezhnykh, Yu.V. Malyukin, V.F. Chekhun // Experimental Oncology. — 2012. — Т. 34, № 2. — С. 101-106. — Бібліогр.: 14 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862752492492685312 |
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| author | Yefimova, S.L. Kurilchenko, I.Yu. Tkacheva, T.N. Rozhkov, V.A. Sorokin, A.V. Lukianova, N.Yu. Bezdenezhnykh, N.A. Malyukin, Yu.V. Chekhun, V.F. |
| author_facet | Yefimova, S.L. Kurilchenko, I.Yu. Tkacheva, T.N. Rozhkov, V.A. Sorokin, A.V. Lukianova, N.Yu. Bezdenezhnykh, N.A. Malyukin, Yu.V. Chekhun, V.F. |
| citation_txt | Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells / S.L. Yefimova, I.Yu. Kurilchenko, T.N. Tkacheva, V.A. Rozhkov, A.V. Sorokin, N.Yu. Lukianova, N.A. Bezdenezhnykh, Yu.V. Malyukin, V.F. Chekhun // Experimental Oncology. — 2012. — Т. 34, № 2. — С. 101-106. — Бібліогр.: 14 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | The aim of this research is to study the dynamics and efficiency of liposome accumulation in sensitive and resistant human breast cancer cells. Methods: Methods of fluorescence microscopy, fluorescence microspectroscopy and MTT-test have been used. Results: The liposome-to-cell interaction and dye cellular uptake in sensitive, cisplatin-resistant and doxorubicin-resistant MCF-7 human breast cancer cells have been analyzed using time changes in both fluorescence resonance energy transfer signal from the donor probe DiO to the acceptor one DiI preloaded in liposomes and cell image brightness. Conclusion: Obtained results show that resistant cells accumulate dye-loaded liposomes more effectively and reveal more effective dye molecule cellular uptake.
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| first_indexed | 2025-12-07T21:16:54Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-138691 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-07T21:16:54Z |
| publishDate | 2012 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Yefimova, S.L. Kurilchenko, I.Yu. Tkacheva, T.N. Rozhkov, V.A. Sorokin, A.V. Lukianova, N.Yu. Bezdenezhnykh, N.A. Malyukin, Yu.V. Chekhun, V.F. 2018-06-19T11:43:19Z 2018-06-19T11:43:19Z 2012 Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells / S.L. Yefimova, I.Yu. Kurilchenko, T.N. Tkacheva, V.A. Rozhkov, A.V. Sorokin, N.Yu. Lukianova, N.A. Bezdenezhnykh, Yu.V. Malyukin, V.F. Chekhun // Experimental Oncology. — 2012. — Т. 34, № 2. — С. 101-106. — Бібліогр.: 14 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/138691 The aim of this research is to study the dynamics and efficiency of liposome accumulation in sensitive and resistant human breast cancer cells. Methods: Methods of fluorescence microscopy, fluorescence microspectroscopy and MTT-test have been used. Results: The liposome-to-cell interaction and dye cellular uptake in sensitive, cisplatin-resistant and doxorubicin-resistant MCF-7 human breast cancer cells have been analyzed using time changes in both fluorescence resonance energy transfer signal from the donor probe DiO to the acceptor one DiI preloaded in liposomes and cell image brightness. Conclusion: Obtained results show that resistant cells accumulate dye-loaded liposomes more effectively and reveal more effective dye molecule cellular uptake. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells Article published earlier |
| spellingShingle | Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells Yefimova, S.L. Kurilchenko, I.Yu. Tkacheva, T.N. Rozhkov, V.A. Sorokin, A.V. Lukianova, N.Yu. Bezdenezhnykh, N.A. Malyukin, Yu.V. Chekhun, V.F. Original contributions |
| title | Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells |
| title_full | Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells |
| title_fullStr | Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells |
| title_full_unstemmed | Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells |
| title_short | Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells |
| title_sort | comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/138691 |
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