Extracellular acidity as favouring factor of tumor progression and metastatic dissemination
The bidirectional interactions between tumor cells and the so-called “host reactive stroma” play a critical role in most of the events characterizing tumor progression and distant organ colonization. This review discusses critical components of tumor environment involved in tumor cell dissemination....
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| Опубліковано в: : | Experimental Oncology |
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| Дата: | 2012 |
| Автори: | , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2012
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| Онлайн доступ: | https://nasplib.isofts.kiev.ua/handle/123456789/138695 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Extracellular acidity as favouring factor of tumor progression and metastatic dissemination / L. Calorini, S. Peppichelli, F. Bianchini // Experimental Oncology. — 2012. — Т. 34, № 2. — С. 79-84. — Бібліогр.: 88 назв. — англ. |
Репозитарії
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nasplib_isofts_kiev_ua-123456789-138695 |
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Calorini, L. Peppichelli, S. Bianchini, F. 2018-06-19T11:47:30Z 2018-06-19T11:47:30Z 2012 Extracellular acidity as favouring factor of tumor progression and metastatic dissemination / L. Calorini, S. Peppichelli, F. Bianchini // Experimental Oncology. — 2012. — Т. 34, № 2. — С. 79-84. — Бібліогр.: 88 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/138695 The bidirectional interactions between tumor cells and the so-called “host reactive stroma” play a critical role in most of the events characterizing tumor progression and distant organ colonization. This review discusses critical components of tumor environment involved in tumor cell dissemination. More specifically, it addresses some of the experimental evidences providing that acidity of tumor environment facilitates local invasiveness and metastasis formation, independently from hypoxia, with which acidity may be associated. Besides, acidity renders tumor cells resistant to radiation therapy and chemotherapeutic drugs. Therefore, this review examines the strategies for raising the low extracellular pH of tumors that might have considerable potential in cancer therapy. This study was funded by grants from Istituto Toscano Tumori, Ente Cassa di Risparmio di Firenze. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Special topic Extracellular acidity as favouring factor of tumor progression and metastatic dissemination Article published earlier |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| title |
Extracellular acidity as favouring factor of tumor progression and metastatic dissemination |
| spellingShingle |
Extracellular acidity as favouring factor of tumor progression and metastatic dissemination Calorini, L. Peppichelli, S. Bianchini, F. Special topic |
| title_short |
Extracellular acidity as favouring factor of tumor progression and metastatic dissemination |
| title_full |
Extracellular acidity as favouring factor of tumor progression and metastatic dissemination |
| title_fullStr |
Extracellular acidity as favouring factor of tumor progression and metastatic dissemination |
| title_full_unstemmed |
Extracellular acidity as favouring factor of tumor progression and metastatic dissemination |
| title_sort |
extracellular acidity as favouring factor of tumor progression and metastatic dissemination |
| author |
Calorini, L. Peppichelli, S. Bianchini, F. |
| author_facet |
Calorini, L. Peppichelli, S. Bianchini, F. |
| topic |
Special topic |
| topic_facet |
Special topic |
| publishDate |
2012 |
| language |
English |
| container_title |
Experimental Oncology |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| format |
Article |
| description |
The bidirectional interactions between tumor cells and the so-called “host reactive stroma” play a critical role in most of the events characterizing tumor progression and distant organ colonization. This review discusses critical components of tumor environment involved in tumor cell dissemination. More specifically, it addresses some of the experimental evidences providing that acidity of tumor environment facilitates local invasiveness and metastasis formation, independently from hypoxia, with which acidity may be associated. Besides, acidity renders tumor cells resistant to radiation therapy and chemotherapeutic drugs. Therefore, this review examines the strategies for raising the low extracellular pH of tumors that might have considerable potential in cancer therapy.
|
| issn |
1812-9269 |
| url |
https://nasplib.isofts.kiev.ua/handle/123456789/138695 |
| citation_txt |
Extracellular acidity as favouring factor of tumor progression and metastatic dissemination / L. Calorini, S. Peppichelli, F. Bianchini // Experimental Oncology. — 2012. — Т. 34, № 2. — С. 79-84. — Бібліогр.: 88 назв. — англ. |
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2025-12-07T17:46:18Z |
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2025-12-07T17:46:18Z |
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