The lipid content of cisplatin- and doxorubicin-resistant MCF-7 human breast cancer cells

The lipid content of cisplatin- and doxorubicin-resistant MCF-7 human breast cancer cells

Aim. To perform the comparative study both of qualitative and quantitative content of lipids in parental and drug resistant breast cancer cells. Materials and methods. Parental (MCF-7/S) and resistant to cisplatin (MCF-7/CP) and doxorubicin (MCF-7/Dox) human breast cancer cells were used in the stud...

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Published in:Experimental Oncology
Date:2012
Main Authors: Todor, I.N., Lukianova, N.Yu., Chekhun, V.F.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2012
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Original contributions
Online Access:https://nasplib.isofts.kiev.ua/handle/123456789/138697
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Journal Title:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Cite this:The lipid content of cisplatin- and doxorubicin-resistant MCF-7 human breast cancer cells / I.N. Todor, N.Yu. Lukianova, V.F. Chekhun // Experimental Oncology. — 2012. — Т. 34, № 2. — С. 97-100. — Бібліогр.: 28 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-138697
record_format dspace
spelling Todor, I.N.
Lukianova, N.Yu.
Chekhun, V.F.
2018-06-19T11:49:01Z
2018-06-19T11:49:01Z
2012
The lipid content of cisplatin- and doxorubicin-resistant MCF-7 human breast cancer cells / I.N. Todor, N.Yu. Lukianova, V.F. Chekhun // Experimental Oncology. — 2012. — Т. 34, № 2. — С. 97-100. — Бібліогр.: 28 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/138697
Aim. To perform the comparative study both of qualitative and quantitative content of lipids in parental and drug resistant breast cancer cells. Materials and methods. Parental (MCF-7/S) and resistant to cisplatin (MCF-7/CP) and doxorubicin (MCF-7/Dox) human breast cancer cells were used in the study. Cholesterol, total lipids and phospholipids content were determined by means of thin-layer chromatography. Results. It was found that cholesterol as well as cholesterol ethers content are significantly higher but diacylglycerols, triacyl­glycerols content are significantly lower in resistant cell strains than in parental (sensitive) cells. Moreover the analysis of individual phospholipids showed the increase of sphingomyelin, phosphatidylserine, cardiolipin, phosphatidic acid and the decrease of phosphatidy­lethanolamine, phosphatidylcholine in MCF-7/CP and MCF-7/Dox cells. Conclusion. Obtained results allow to suggest that the lipid profile changes can mediate the modulation of membrane fluidity in drug resistant MCF-7 breast cancer cells.
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Original contributions
The lipid content of cisplatin- and doxorubicin-resistant MCF-7 human breast cancer cells
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title The lipid content of cisplatin- and doxorubicin-resistant MCF-7 human breast cancer cells
spellingShingle The lipid content of cisplatin- and doxorubicin-resistant MCF-7 human breast cancer cells
Todor, I.N.
Lukianova, N.Yu.
Chekhun, V.F.
Original contributions
title_short The lipid content of cisplatin- and doxorubicin-resistant MCF-7 human breast cancer cells
title_full The lipid content of cisplatin- and doxorubicin-resistant MCF-7 human breast cancer cells
title_fullStr The lipid content of cisplatin- and doxorubicin-resistant MCF-7 human breast cancer cells
title_full_unstemmed The lipid content of cisplatin- and doxorubicin-resistant MCF-7 human breast cancer cells
title_sort lipid content of cisplatin- and doxorubicin-resistant mcf-7 human breast cancer cells
author Todor, I.N.
Lukianova, N.Yu.
Chekhun, V.F.
author_facet Todor, I.N.
Lukianova, N.Yu.
Chekhun, V.F.
topic Original contributions
topic_facet Original contributions
publishDate 2012
language English
container_title Experimental Oncology
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
format Article
description Aim. To perform the comparative study both of qualitative and quantitative content of lipids in parental and drug resistant breast cancer cells. Materials and methods. Parental (MCF-7/S) and resistant to cisplatin (MCF-7/CP) and doxorubicin (MCF-7/Dox) human breast cancer cells were used in the study. Cholesterol, total lipids and phospholipids content were determined by means of thin-layer chromatography. Results. It was found that cholesterol as well as cholesterol ethers content are significantly higher but diacylglycerols, triacyl­glycerols content are significantly lower in resistant cell strains than in parental (sensitive) cells. Moreover the analysis of individual phospholipids showed the increase of sphingomyelin, phosphatidylserine, cardiolipin, phosphatidic acid and the decrease of phosphatidy­lethanolamine, phosphatidylcholine in MCF-7/CP and MCF-7/Dox cells. Conclusion. Obtained results allow to suggest that the lipid profile changes can mediate the modulation of membrane fluidity in drug resistant MCF-7 breast cancer cells.
issn 1812-9269
url https://nasplib.isofts.kiev.ua/handle/123456789/138697
citation_txt The lipid content of cisplatin- and doxorubicin-resistant MCF-7 human breast cancer cells / I.N. Todor, N.Yu. Lukianova, V.F. Chekhun // Experimental Oncology. — 2012. — Т. 34, № 2. — С. 97-100. — Бібліогр.: 28 назв. — англ.
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first_indexed 2025-12-07T18:18:30Z
last_indexed 2025-12-07T18:18:30Z
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