Production of nitrogen oxide derivatives under the influence of NO-synthase inhibitors and natural compounds in mice with transplanted tumors

Production of nitrogen oxide derivatives under the influence of NO-synthase inhibitors and natural compounds in mice with transplanted tumors

Aim: The aim of the present study was to investigate the dynamics of nitric oxide derivative (NOD) formation in mice with transplanted tumors and to analize whether synthetic NO-synthase inhibitors, NO-donors and natural compounds could modulate NOD synthesis. Materials and Methods: In the study F1(...

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Published in:Experimental Oncology
Date:2012
Main Authors: Deryagina, V.P., Ryzhova, N.I., Golubkina, N.A.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2012
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Online Access:https://nasplib.isofts.kiev.ua/handle/123456789/138709
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Journal Title:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Cite this:Production of nitrogen oxide derivatives under the influence of NO-synthase inhibitors and natural compounds in mice with transplanted tumors / V.P. Deryagina, N.I. Ryzhova, N.A. Golubkina // Experimental Oncology. — 2012. — Т. 34, № 1. — С. 29-33. — Бібліогр.: 23 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-138709
record_format dspace
spelling Deryagina, V.P.
Ryzhova, N.I.
Golubkina, N.A.
2018-06-19T12:02:34Z
2018-06-19T12:02:34Z
2012
Production of nitrogen oxide derivatives under the influence of NO-synthase inhibitors and natural compounds in mice with transplanted tumors / V.P. Deryagina, N.I. Ryzhova, N.A. Golubkina // Experimental Oncology. — 2012. — Т. 34, № 1. — С. 29-33. — Бібліогр.: 23 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/138709
Aim: The aim of the present study was to investigate the dynamics of nitric oxide derivative (NOD) formation in mice with transplanted tumors and to analize whether synthetic NO-synthase inhibitors, NO-donors and natural compounds could modulate NOD synthesis. Materials and Methods: In the study F1(C57BlxCBA), CBA/Lac, BDF and Balb/c mice were used. Endogenous NOD synthesis in mice with transplanted Ehrlich carcinoma (EC) and Lewis lung carcinoma (LLC) was estimated by measuring urine nitrates (NA) and nitrites (NI) excretion and their concentration in tumor tissue determined by cadmium-reduction method. Results: It is shown that EC development is accompanied by increased endogenous NOD formation whereas LLC growth — by its decrease. Total NOD excretion with urine in EC-bearing mice during tumor development was in the range of 1.1x10–7-7.0x10–6 mol/kg body weight that was 1.7–6.8 times higher than that in LLC-bearing mice. Treatment of EC-bearing animals with Nώ-nitro-L-arginine and aminoguanidine resulted in decreased NOD formation causing moderate tumor growth retardation. Effect of treatment with nitroprusside was shown to be dependent on the rout of its administration and dosage. Treatment of EC-bearing mice with picnogenol, tannic acid, spirulina and paprika enriched with selenium resulted in tumor growth inhibition at the early stage of EC growth accompanied by stimulation of endogenous NOD formation. Conclusion: Regulation of endogenous NOD formation towards normal physiological levels or hyperproduction of these compounds may result in tumor growth suppression.
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Original contributions
Production of nitrogen oxide derivatives under the influence of NO-synthase inhibitors and natural compounds in mice with transplanted tumors
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title Production of nitrogen oxide derivatives under the influence of NO-synthase inhibitors and natural compounds in mice with transplanted tumors
spellingShingle Production of nitrogen oxide derivatives under the influence of NO-synthase inhibitors and natural compounds in mice with transplanted tumors
Deryagina, V.P.
Ryzhova, N.I.
Golubkina, N.A.
Original contributions
title_short Production of nitrogen oxide derivatives under the influence of NO-synthase inhibitors and natural compounds in mice with transplanted tumors
title_full Production of nitrogen oxide derivatives under the influence of NO-synthase inhibitors and natural compounds in mice with transplanted tumors
title_fullStr Production of nitrogen oxide derivatives under the influence of NO-synthase inhibitors and natural compounds in mice with transplanted tumors
title_full_unstemmed Production of nitrogen oxide derivatives under the influence of NO-synthase inhibitors and natural compounds in mice with transplanted tumors
title_sort production of nitrogen oxide derivatives under the influence of no-synthase inhibitors and natural compounds in mice with transplanted tumors
author Deryagina, V.P.
Ryzhova, N.I.
Golubkina, N.A.
author_facet Deryagina, V.P.
Ryzhova, N.I.
Golubkina, N.A.
topic Original contributions
topic_facet Original contributions
publishDate 2012
language English
container_title Experimental Oncology
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
format Article
description Aim: The aim of the present study was to investigate the dynamics of nitric oxide derivative (NOD) formation in mice with transplanted tumors and to analize whether synthetic NO-synthase inhibitors, NO-donors and natural compounds could modulate NOD synthesis. Materials and Methods: In the study F1(C57BlxCBA), CBA/Lac, BDF and Balb/c mice were used. Endogenous NOD synthesis in mice with transplanted Ehrlich carcinoma (EC) and Lewis lung carcinoma (LLC) was estimated by measuring urine nitrates (NA) and nitrites (NI) excretion and their concentration in tumor tissue determined by cadmium-reduction method. Results: It is shown that EC development is accompanied by increased endogenous NOD formation whereas LLC growth — by its decrease. Total NOD excretion with urine in EC-bearing mice during tumor development was in the range of 1.1x10–7-7.0x10–6 mol/kg body weight that was 1.7–6.8 times higher than that in LLC-bearing mice. Treatment of EC-bearing animals with Nώ-nitro-L-arginine and aminoguanidine resulted in decreased NOD formation causing moderate tumor growth retardation. Effect of treatment with nitroprusside was shown to be dependent on the rout of its administration and dosage. Treatment of EC-bearing mice with picnogenol, tannic acid, spirulina and paprika enriched with selenium resulted in tumor growth inhibition at the early stage of EC growth accompanied by stimulation of endogenous NOD formation. Conclusion: Regulation of endogenous NOD formation towards normal physiological levels or hyperproduction of these compounds may result in tumor growth suppression.
issn 1812-9269
url https://nasplib.isofts.kiev.ua/handle/123456789/138709
citation_txt Production of nitrogen oxide derivatives under the influence of NO-synthase inhibitors and natural compounds in mice with transplanted tumors / V.P. Deryagina, N.I. Ryzhova, N.A. Golubkina // Experimental Oncology. — 2012. — Т. 34, № 1. — С. 29-33. — Бібліогр.: 23 назв. — англ.
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AT golubkinana productionofnitrogenoxidederivativesundertheinfluenceofnosynthaseinhibitorsandnaturalcompoundsinmicewithtransplantedtumors
first_indexed 2025-12-02T01:21:49Z
last_indexed 2025-12-02T01:21:49Z
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