Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in north India
Background:Acute lymphoblastic leukemia (ALL) is the most worldwide common type of childhood cancer. Methylenetetrahydrofolate reductase (MTHFR) and 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR) participate in folate pathways and are known as critical factors for DNA integrity as wel...
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| Veröffentlicht in: | Experimental Oncology |
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| Datum: | 2012 |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2012
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Zitieren: | Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in north India / M. Nikbakht, K. MalekZadeh, A. Kumar Jha, M. Askari, R.K. Marwaha, D. Kaul, J. Kaur // Experimental Oncology. — 2012. — Т. 34, № 1. — С. 43-48. — Бібліогр.: 44 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862634411961352192 |
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| author | Nikbakht, M. MalekZadeh, K. Kumar Jha, A. Askari, M. Marwaha, R.K. Kaul, D. Kaur, J. |
| author_facet | Nikbakht, M. MalekZadeh, K. Kumar Jha, A. Askari, M. Marwaha, R.K. Kaul, D. Kaur, J. |
| citation_txt | Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in north India / M. Nikbakht, K. MalekZadeh, A. Kumar Jha, M. Askari, R.K. Marwaha, D. Kaul, J. Kaur // Experimental Oncology. — 2012. — Т. 34, № 1. — С. 43-48. — Бібліогр.: 44 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Background:Acute lymphoblastic leukemia (ALL) is the most worldwide common type of childhood cancer. Methylenetetrahydrofolate reductase (MTHFR) and 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR) participate in folate pathways and are known as critical factors for DNA integrity as well as DNA hypomethylation. The aim of this work is to investigate frequency of MTHFR (677C→T and 1298A→C) and MTR (2756A→G) polymorphisms and their interaction with respect to possible effect on risk of childhood ALL among North Indian population. Procedure: A case control study from has been conducted on bone marrow and peripheral blood samples from 125 ALL patients and 100 sex-age matched healthy controls using PCR-RFLP method. Results: No statistically significant differences were observed for different genotypes between patients and controls (p>0.05). Significant difference for the risk of ALL in individuals having genotype of MTHFR 677TT (OR=0.61, 95% CI=0.21–1.77) and MTHFR 1298CC (OR=0.56, 95% CI=0.18–1.68) was not observed. The correlation of SNP of MTR gene and risk of ALL was not observed, too. Conclusions: The differences in distribution of possible combined genotypes of MTHFR (677C→T, 1298A→C) and MTR (2756A→G) between ALL patients and controls were statistically insignificant.
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| first_indexed | 2025-11-30T16:08:15Z |
| format | Article |
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| id | nasplib_isofts_kiev_ua-123456789-138722 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-11-30T16:08:15Z |
| publishDate | 2012 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
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| spelling | Nikbakht, M. MalekZadeh, K. Kumar Jha, A. Askari, M. Marwaha, R.K. Kaul, D. Kaur, J. 2018-06-19T12:12:41Z 2018-06-19T12:12:41Z 2012 Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in north India / M. Nikbakht, K. MalekZadeh, A. Kumar Jha, M. Askari, R.K. Marwaha, D. Kaul, J. Kaur // Experimental Oncology. — 2012. — Т. 34, № 1. — С. 43-48. — Бібліогр.: 44 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/138722 Background:Acute lymphoblastic leukemia (ALL) is the most worldwide common type of childhood cancer. Methylenetetrahydrofolate reductase (MTHFR) and 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR) participate in folate pathways and are known as critical factors for DNA integrity as well as DNA hypomethylation. The aim of this work is to investigate frequency of MTHFR (677C→T and 1298A→C) and MTR (2756A→G) polymorphisms and their interaction with respect to possible effect on risk of childhood ALL among North Indian population. Procedure: A case control study from has been conducted on bone marrow and peripheral blood samples from 125 ALL patients and 100 sex-age matched healthy controls using PCR-RFLP method. Results: No statistically significant differences were observed for different genotypes between patients and controls (p>0.05). Significant difference for the risk of ALL in individuals having genotype of MTHFR 677TT (OR=0.61, 95% CI=0.21–1.77) and MTHFR 1298CC (OR=0.56, 95% CI=0.18–1.68) was not observed. The correlation of SNP of MTR gene and risk of ALL was not observed, too. Conclusions: The differences in distribution of possible combined genotypes of MTHFR (677C→T, 1298A→C) and MTR (2756A→G) between ALL patients and controls were statistically insignificant. We are indebted to all patients and their parents who consented to participate in this study. This work was supported by University Grand Commission (UGC) India. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in north India Article published earlier |
| spellingShingle | Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in north India Nikbakht, M. MalekZadeh, K. Kumar Jha, A. Askari, M. Marwaha, R.K. Kaul, D. Kaur, J. Original contributions |
| title | Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in north India |
| title_full | Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in north India |
| title_fullStr | Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in north India |
| title_full_unstemmed | Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in north India |
| title_short | Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in north India |
| title_sort | polymorphisms of mthfr and mtr genes are not related to susceptibility to childhood all in north india |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/138722 |
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