Influence of surgical resection no plasma Endoglin (CD105) level in non-small cell lung cancer patients
Background and Aim: Endoglin is a proliferation-associated antigen on endothelial cells and essential for angiogenesis. Soluble endoglin (s‑endoglin), formed by proteolytic cleavage of ectodomain of membrane receptor could be an indicator of tumor‑activated endothelium. The aim of present study was...
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| Опубліковано в: | Experimental Oncology |
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| Дата: | 2012 |
| ISSN: | 1812-9269 |
| Автори: | , , , , , , |
| Формат: | Стаття |
| Мова: | Англійська |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2012
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| Онлайн доступ: | https://nasplib.isofts.kiev.ua/handle/123456789/138724 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Influence of surgical resection no plasma Endoglin (CD105) level in non-small cell lung cancer patients / E. Kopczynska, M. Dancewicz, J. Kowalewski, R. Makarewicz, H. Kardymowicz, A. Kaczmarczyk, T. Tyrakowski // Experimental Oncology. — 2012. — Т. 34, № 1. — С. 53-56. — Бібліогр.: 31 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862743195856666624 |
|---|---|
| author | Kopczynska, E. Dancewicz, M. Kowalewski, J. Makarewicz, R. Kardymowicz, H. Kaczmarczyk, A. Tyrakowski, T. |
| author_facet | Kopczynska, E. Dancewicz, M. Kowalewski, J. Makarewicz, R. Kardymowicz, H. Kaczmarczyk, A. Tyrakowski, T. |
| citation_txt | Influence of surgical resection no plasma Endoglin (CD105) level in non-small cell lung cancer patients / E. Kopczynska, M. Dancewicz, J. Kowalewski, R. Makarewicz, H. Kardymowicz, A. Kaczmarczyk, T. Tyrakowski // Experimental Oncology. — 2012. — Т. 34, № 1. — С. 53-56. — Бібліогр.: 31 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Background and Aim: Endoglin is a proliferation-associated antigen on endothelial cells and essential for angiogenesis. Soluble endoglin (s‑endoglin), formed by proteolytic cleavage of ectodomain of membrane receptor could be an indicator of tumor‑activated endothelium. The aim of present study was to analyze changes of s‑endoglin level in plasma of lung cancer patients following surgical resection and to estimate the correlation of s‑endoglin with other soluble receptors, sTie2 and sVEGF R1. Patients and Methods: The study group consisted of 37 patients with stage I of non-small cell lung cancer. Plasma concentrations of s‑endoglin, sTie2 and sVEGF R1 were evaluated by ELISA, three times: before surgical resection and on postoperative day 7 and 30. Results: The median of s‑endoglin concentration decreased significantly on postoperative day 7 when compared with preoperative level and next increased on 30th day and it was comparable with that before surgery. s-Endoglin correlated with another soluble receptors, with sTie2 both before surgery (r=0.44) and on postoperative day 7 (r=0.52) and on 30th day (r=0.58), with sVEGF R1 — only on postoperative day 7 (r=0.75). Conclusion: The increased level of serum endoglin in lung cancer patients compared to controls and its changes after surgical treatment suggest potential application of soluble form of endoglin as potential tumor marker.
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| first_indexed | 2025-12-07T20:29:38Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-138724 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-07T20:29:38Z |
| publishDate | 2012 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Kopczynska, E. Dancewicz, M. Kowalewski, J. Makarewicz, R. Kardymowicz, H. Kaczmarczyk, A. Tyrakowski, T. 2018-06-19T12:13:57Z 2018-06-19T12:13:57Z 2012 Influence of surgical resection no plasma Endoglin (CD105) level in non-small cell lung cancer patients / E. Kopczynska, M. Dancewicz, J. Kowalewski, R. Makarewicz, H. Kardymowicz, A. Kaczmarczyk, T. Tyrakowski // Experimental Oncology. — 2012. — Т. 34, № 1. — С. 53-56. — Бібліогр.: 31 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/138724 Background and Aim: Endoglin is a proliferation-associated antigen on endothelial cells and essential for angiogenesis. Soluble endoglin (s‑endoglin), formed by proteolytic cleavage of ectodomain of membrane receptor could be an indicator of tumor‑activated endothelium. The aim of present study was to analyze changes of s‑endoglin level in plasma of lung cancer patients following surgical resection and to estimate the correlation of s‑endoglin with other soluble receptors, sTie2 and sVEGF R1. Patients and Methods: The study group consisted of 37 patients with stage I of non-small cell lung cancer. Plasma concentrations of s‑endoglin, sTie2 and sVEGF R1 were evaluated by ELISA, three times: before surgical resection and on postoperative day 7 and 30. Results: The median of s‑endoglin concentration decreased significantly on postoperative day 7 when compared with preoperative level and next increased on 30th day and it was comparable with that before surgery. s-Endoglin correlated with another soluble receptors, with sTie2 both before surgery (r=0.44) and on postoperative day 7 (r=0.52) and on 30th day (r=0.58), with sVEGF R1 — only on postoperative day 7 (r=0.75). Conclusion: The increased level of serum endoglin in lung cancer patients compared to controls and its changes after surgical treatment suggest potential application of soluble form of endoglin as potential tumor marker. The work was supported by the subsidy for financing the statutory activity of Nicolaus Copernicus University in Toruń, number 461/2010. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Influence of surgical resection no plasma Endoglin (CD105) level in non-small cell lung cancer patients Article published earlier |
| spellingShingle | Influence of surgical resection no plasma Endoglin (CD105) level in non-small cell lung cancer patients Kopczynska, E. Dancewicz, M. Kowalewski, J. Makarewicz, R. Kardymowicz, H. Kaczmarczyk, A. Tyrakowski, T. Original contributions |
| title | Influence of surgical resection no plasma Endoglin (CD105) level in non-small cell lung cancer patients |
| title_full | Influence of surgical resection no plasma Endoglin (CD105) level in non-small cell lung cancer patients |
| title_fullStr | Influence of surgical resection no plasma Endoglin (CD105) level in non-small cell lung cancer patients |
| title_full_unstemmed | Influence of surgical resection no plasma Endoglin (CD105) level in non-small cell lung cancer patients |
| title_short | Influence of surgical resection no plasma Endoglin (CD105) level in non-small cell lung cancer patients |
| title_sort | influence of surgical resection no plasma endoglin (cd105) level in non-small cell lung cancer patients |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/138724 |
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