The multilevel regulation of CD95 signaling outcome
CD95, also called Fas or APO-1, was the first death receptor (DR) identified and characterized. Studies on CD95 receptor signaling revealed the versatile principles of cell fate regulation via DR. DRs could exert both pro- and anti-apoptotic effects depending on clustering, internalization or signal...
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| Опубліковано в: : | Experimental Oncology |
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| Дата: | 2012 |
| Автори: | , , |
| Формат: | Стаття |
| Мова: | Англійська |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2012
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| Онлайн доступ: | https://nasplib.isofts.kiev.ua/handle/123456789/138726 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | The multilevel regulation of CD95 signaling outcome / M. Yurchenko, L.M. Shlapatska, S.P. Sidorenko // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 153-159. — Бібліогр.: 71 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862747188311883776 |
|---|---|
| author | Yurchenko, M. Shlapatska, L.M. Sidorenko, S.P. |
| author_facet | Yurchenko, M. Shlapatska, L.M. Sidorenko, S.P. |
| citation_txt | The multilevel regulation of CD95 signaling outcome / M. Yurchenko, L.M. Shlapatska, S.P. Sidorenko // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 153-159. — Бібліогр.: 71 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | CD95, also called Fas or APO-1, was the first death receptor (DR) identified and characterized. Studies on CD95 receptor signaling revealed the versatile principles of cell fate regulation via DR. DRs could exert both pro- and anti-apoptotic effects depending on clustering, internalization or signaling thresholds and other extracellular signals. It became clear that molecular network regulating cell death and survival is under the multilevel control. In this Review we focus on the regulation of CD95 signaling and provide brief analysis of molecular switches of its pro- and antiapoptotic functions. At least five levels of life-death cell regulation via CD95 could be tracked: extracellular, membrane, DISC, mitochondrial, and miRNA. The cellular outcome of signaling via DRs depends on other extracellular signals and availability of different intracellular components of signal transduction pathways. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”.
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| first_indexed | 2025-12-07T20:49:33Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-138726 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-07T20:49:33Z |
| publishDate | 2012 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Yurchenko, M. Shlapatska, L.M. Sidorenko, S.P. 2018-06-19T12:15:01Z 2018-06-19T12:15:01Z 2012 The multilevel regulation of CD95 signaling outcome / M. Yurchenko, L.M. Shlapatska, S.P. Sidorenko // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 153-159. — Бібліогр.: 71 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/138726 CD95, also called Fas or APO-1, was the first death receptor (DR) identified and characterized. Studies on CD95 receptor signaling revealed the versatile principles of cell fate regulation via DR. DRs could exert both pro- and anti-apoptotic effects depending on clustering, internalization or signaling thresholds and other extracellular signals. It became clear that molecular network regulating cell death and survival is under the multilevel control. In this Review we focus on the regulation of CD95 signaling and provide brief analysis of molecular switches of its pro- and antiapoptotic functions. At least five levels of life-death cell regulation via CD95 could be tracked: extracellular, membrane, DISC, mitochondrial, and miRNA. The cellular outcome of signaling via DRs depends on other extracellular signals and availability of different intracellular components of signal transduction pathways. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Reviews The multilevel regulation of CD95 signaling outcome Article published earlier |
| spellingShingle | The multilevel regulation of CD95 signaling outcome Yurchenko, M. Shlapatska, L.M. Sidorenko, S.P. Reviews |
| title | The multilevel regulation of CD95 signaling outcome |
| title_full | The multilevel regulation of CD95 signaling outcome |
| title_fullStr | The multilevel regulation of CD95 signaling outcome |
| title_full_unstemmed | The multilevel regulation of CD95 signaling outcome |
| title_short | The multilevel regulation of CD95 signaling outcome |
| title_sort | multilevel regulation of cd95 signaling outcome |
| topic | Reviews |
| topic_facet | Reviews |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/138726 |
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