Foreword to the special issue on apoptosis
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| Date: | 2012 |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2012
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| Series: | Experimental Oncology |
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/138728 |
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| Cite this: | Foreword to the special issue on apoptosis / V.F. Chekhun // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 138. — Бібліогр.: 21 назв. — англ. |
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nasplib_isofts_kiev_ua-123456789-1387282025-02-09T21:31:10Z Foreword to the special issue on apoptosis Chekhun, V.F. Editorial 2012 Article Foreword to the special issue on apoptosis / V.F. Chekhun // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 138. — Бібліогр.: 21 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/138728 en Experimental Oncology application/pdf Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
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Editorial Editorial Chekhun, V.F. Foreword to the special issue on apoptosis Experimental Oncology |
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Article |
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Chekhun, V.F. |
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Chekhun, V.F. |
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Chekhun, V.F. |
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Foreword to the special issue on apoptosis |
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Foreword to the special issue on apoptosis |
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Foreword to the special issue on apoptosis |
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Foreword to the special issue on apoptosis |
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Foreword to the special issue on apoptosis |
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foreword to the special issue on apoptosis |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
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2012 |
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Editorial |
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https://nasplib.isofts.kiev.ua/handle/123456789/138728 |
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Foreword to the special issue on apoptosis / V.F. Chekhun // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 138. — Бібліогр.: 21 назв. — англ. |
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Experimental Oncology |
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AT chekhunvf forewordtothespecialissueonapoptosis |
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2025-12-01T00:27:24Z |
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2025-12-01T00:27:24Z |
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1850263572642267136 |
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FOREWORD TO THE SPECIAL ISSUE ON APOPTOSIS
Dear Reader!
The 2012 Special Issue of Experimental Oncology
is devoted to the 40th anniversary of one of the crucial
milestones in biology and medicine, recognized today
as the «birthday» of apoptosis research. The term
apoptosis was coined by John Kerr, Andrew Wyllie and
Alastair Currie in the article published in British Journal
of Cancer in 1972. Besides the important statement
that apoptosis «is an active, inherently programmed
phenomenon», the authors speculated that «hyperpla-
sia might sometimes result from decreased apoptosis
rather than increased mitosis» and also proposed that
«histological assessment of the «apoptotic index»
of a tumour several days after the commencement
of therapy might, in some cases, provide a useful mea-
sure of its response» [1]. Initially met without enthu-
siasm, the concept of apoptosis has been confirmed
in numerous studies and as of the autumn of 2012,
this landmark paper had received 11657 (!) citations.
The reviews presented in the issue prove the tre-
mendous progress made in recent years in the study
of apoptosis and related phenomena applied to cancer
research. The contributing authors from Canada, Iran,
Ireland, Italy, Japan, New Zealand, Switzerland, The
Netherlands, Ukraine and USA (chiefly) are the authori-
tative experts in their fields. Two opening reviews deal
with historical aspects of cell death research [2, 3]. The
following four papers are devoted to the analysis of ex-
trinsic, death receptor-dependent apoptotic pathway,
providing an outlook on caspase-8-mediated cell-
suicide signaling [4–7]. The role of c-FLIP isoforms
as critical anti-apoptotic/drug resistance factors and
novel c-FLIP targeted agents for cancer therapy are
also discussed [7]. Subsequent two papers provide
in-depth information on the intrinsic (mitochondrial)
death pathway with particular reference to the role
of the Bcl-2 family members [8, 9]. The next paper
describes the inhibitors of apoptosis (IAP) proteins
and their role in cell death and signaling pathways [10].
A great deal of attention has been paid to the devel-
opment and testing of the IAP antagonists. Next, our
current knowledge of alternative splicing of apoptosis-
associated genes as well as mechanisms of transla-
tion control in apoptosis is summarized [11, 12]. The
authors of the review [13] dwell on the sphingolipid-
mediated regulation of apoptosis. A detailed discus-
sion of the cell-cycle checkpoint signaling, DNA repair
system and apoptotic pathways activated in response
to DNA damage is also presented [14].
The following part of the issue moves from cell
death signaling to modern approaches used for detec-
tion and quantification of apoptotic cells (see [15–17]).
The application of in vivo apoptosis imaging by means
of 99mTc-annexin V scintigraphy to monitor early re-
sponse to therapy is analyzed more thoroughly due
to the large clinical experience of authors [17]. Recent
progress in studying cell death and cell proliferation
during and after radiation treatment is in the focus
of the following paper [18]. Of special importance are
the new data on the involvement of tumor microenvi-
ronment in response to irradiation.
Over the decades of the intense research, it is be-
coming clear that several cell death modalities exist
which are distinct from apoptosis. Some of these cell
death subroutines including autophagy [19], necrop-
tosis [10], cellular senescence [20] and «cannibalism»
[21] are mainly discussed in the final part of this issue.
Since nonapoptotic modes of the cell demise appear
to be responsible for the elimination of cancer cells,
both spontaneous and therapy-induced, this informa-
tion will be useful from the viewpoint of the search for
alternative approaches in cancer therapy.
Finally, I am grateful to all the authors for their ge-
ne rous contributions to this issue. My special thanks
to Dr. Alex Philchenkov for the original idea and its
successful realization.
Prof. V.F. Chekhun, Editor-in-Chief
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Exp Oncol 2012
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