Programmed cell death and apoptosis — where it came from and where it is going: From Elie Metchnikoff to the control of caspases
The story of cell death began with the origins of cell biology, including important observations by Elie (Ilya) Metchnikoff, who realized that phagocytes engulfed dying cells. Most of the early studies were observational. By the middle of the 20th C, researchers were beginning to explore how cells d...
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| Veröffentlicht in: | Experimental Oncology |
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| Datum: | 2012 |
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| Format: | Artikel |
| Sprache: | Englisch |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2012
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Zitieren: | Programmed cell death and apoptosis — where it came from and where it is going: From Elie Metchnikoff to the control of caspases / N. Maghsoudi, Z. Zaketi, R.A. Lockshin // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 146-152. — Бібліогр.: 64 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862589615937945600 |
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| author | Maghsoudi, N. Zaketi, Z. Lockshin, R.A. |
| author_facet | Maghsoudi, N. Zaketi, Z. Lockshin, R.A. |
| citation_txt | Programmed cell death and apoptosis — where it came from and where it is going: From Elie Metchnikoff to the control of caspases / N. Maghsoudi, Z. Zaketi, R.A. Lockshin // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 146-152. — Бібліогр.: 64 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | The story of cell death began with the origins of cell biology, including important observations by Elie (Ilya) Metchnikoff, who realized that phagocytes engulfed dying cells. Most of the early studies were observational. By the middle of the 20th C, researchers were beginning to explore how cells died, had recognized that cell death was a physiologically controlled process, that the most common mode of death (“shrinkage necrosis”, later apoptosis) was tightly controlled, and were speculating whether lysosomes were “suicide bags”. Just prior to 1990 several discoveries led to rapid expansion of interest in the field and elucidation of the mechanisms of apoptosis. Closer to the beginning of the 21st C comprehensive analysis of the molecules that controlled and effected apoptosis led to the conclusion that autophagic processes were linked to apoptosis and could serve to limit or increase cell death. Today, realizing that knowledge of the components of cell death has not yet produced pharmaceuticals of therapeutic value, research is turning to questions of what metabolic or other mechanisms indirectly control the activation or suppression of the cell death positive feedback loop. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”.
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| first_indexed | 2025-11-27T03:13:44Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-138730 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-11-27T03:13:44Z |
| publishDate | 2012 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Maghsoudi, N. Zaketi, Z. Lockshin, R.A. 2018-06-19T12:18:19Z 2018-06-19T12:18:19Z 2012 Programmed cell death and apoptosis — where it came from and where it is going: From Elie Metchnikoff to the control of caspases / N. Maghsoudi, Z. Zaketi, R.A. Lockshin // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 146-152. — Бібліогр.: 64 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/138730 The story of cell death began with the origins of cell biology, including important observations by Elie (Ilya) Metchnikoff, who realized that phagocytes engulfed dying cells. Most of the early studies were observational. By the middle of the 20th C, researchers were beginning to explore how cells died, had recognized that cell death was a physiologically controlled process, that the most common mode of death (“shrinkage necrosis”, later apoptosis) was tightly controlled, and were speculating whether lysosomes were “suicide bags”. Just prior to 1990 several discoveries led to rapid expansion of interest in the field and elucidation of the mechanisms of apoptosis. Closer to the beginning of the 21st C comprehensive analysis of the molecules that controlled and effected apoptosis led to the conclusion that autophagic processes were linked to apoptosis and could serve to limit or increase cell death. Today, realizing that knowledge of the components of cell death has not yet produced pharmaceuticals of therapeutic value, research is turning to questions of what metabolic or other mechanisms indirectly control the activation or suppression of the cell death positive feedback loop. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”. Supported in part by the International Cell Death Society and by NIH grants 1R1541094351 (National Institute of Infectious Diseases) and 5T34GM070387-08 (National Institute of General Medical Sciences) to ZZ. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Reviews Programmed cell death and apoptosis — where it came from and where it is going: From Elie Metchnikoff to the control of caspases Article published earlier |
| spellingShingle | Programmed cell death and apoptosis — where it came from and where it is going: From Elie Metchnikoff to the control of caspases Maghsoudi, N. Zaketi, Z. Lockshin, R.A. Reviews |
| title | Programmed cell death and apoptosis — where it came from and where it is going: From Elie Metchnikoff to the control of caspases |
| title_full | Programmed cell death and apoptosis — where it came from and where it is going: From Elie Metchnikoff to the control of caspases |
| title_fullStr | Programmed cell death and apoptosis — where it came from and where it is going: From Elie Metchnikoff to the control of caspases |
| title_full_unstemmed | Programmed cell death and apoptosis — where it came from and where it is going: From Elie Metchnikoff to the control of caspases |
| title_short | Programmed cell death and apoptosis — where it came from and where it is going: From Elie Metchnikoff to the control of caspases |
| title_sort | programmed cell death and apoptosis — where it came from and where it is going: from elie metchnikoff to the control of caspases |
| topic | Reviews |
| topic_facet | Reviews |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/138730 |
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