Clinical impact of MDR1-expression in testicular germ cell cancer

• Published in: Experimental Oncology
• Date: 2007
• Main Authors: Schrader, A.J., Seger, M., Konrad, L., Olbert, P., Hegele, A., Hofmann, R., Heidenreich, A.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2007
• Subjects: Original contributions
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/138979
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Clinical impact of MDR1-expression in testicular germ cell cancer / A. J. Schrader, M. Seger, L. Konrad, P. Olbert, A. Hegele, R. Hofmann, A. Heidenreich // Experimental Oncology. — 2007. — Т. 29, № 3. — С. 212–216. — Бібліогр.: 22 назв. — англ.

Aim: The multidrug resistance protein 1 (MDR1, P-gp, p-170) is a membrane glycoprotein that acts as an energy-dependent drug efflux pump. In various malignancies its expression is associated with resistance to diverse cytostatic drugs, and therefore predicts resistance to systemic treatment. The aim...