A possible mechanism of antitumor activity of 5 (5’,6’ benzocoumaroyl-3’)-methylaminouracil in vivo

• Published in: Experimental Oncology
• Date: 2007
• Main Authors: Kopylchuk, H.P., Shmarakov, I.O., Marchenko, M.M.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2007
• Subjects: Short communications
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/139018
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: A possible mechanism of antitumor activity of 5 (5’,6’ benzocoumaroyl-3’)-methylaminouracil in vivo / H.P. Kopylchuk, I.O. Shmarakov, M.M. Marchenko // Experimental Oncology. — 2007. — Т. 29, № 4. — С. 320–322. — Бібліогр.: 14 назв. — англ.

Aim: To analyze possible mechanisms of anticancer activity of hydrobromide 5-(5’,6’-benzocoumaroyl-3’)-methylaminouracil (BCU) in vivo. Methods: BCU was administered at the dose of 6 mg/kg for seven days to rats bearing Guerin carcinoma (Gc). Interaction of BCU with DNA isolated from Gc cells was an...