Amifostine can differentially modulate DNA double-strand breaks and apoptosis induced by idarubicin in normal and cancer cells

• Published in: Experimental Oncology
• Date: 2008
• ISSN: 1812-9269
• Main Authors: Wozniak, K., Gloc, E., Morawiec, Z., Blasiak, J.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2008
• Subjects: Original contributions
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/139026
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Amifostine can differentially modulate DNA double-strand breaks and apoptosis induced by idarubicin in normal and cancer cells / K. Wozniak, E. Gloc, Z. Morawiec, J. Blasiak // Experimental Oncology. — 2008. — Т. 30, № 1. — С. 22–28. — Бібліогр.: 34 назв. — англ.

We have previously shown that amifostine differentially modulated the DNA-damaging action of idarubicin in normal and cancer cells and that the presence of p53 protein and oncogenic tyrosine kinases might play a role in this diversity. Aim: To investigate further this effect we have studied the infl...