The intersection between DNA damage response and cell death pathways
Apoptosis is a finely regulated process that serves to determine the fate of cells in response to various stresses. One such stress is DNA damage, which not only can signal repair processes but is also intimately involved in regulating cell fate. In this review we examine the relationship between th...
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| Опубліковано в: : | Experimental Oncology |
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| Дата: | 2012 |
| Автори: | , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2012
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| Онлайн доступ: | https://nasplib.isofts.kiev.ua/handle/123456789/139048 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | The intersection between DNA damage response and cell death pathways / S. Howsheen, E.S. Yang // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 243-254. — Бібліогр.: 128 назв. — англ. |
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nasplib_isofts_kiev_ua-123456789-139048 |
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Nowsheen, S. Yang, E.S. 2018-06-19T18:46:37Z 2018-06-19T18:46:37Z 2012 The intersection between DNA damage response and cell death pathways / S. Howsheen, E.S. Yang // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 243-254. — Бібліогр.: 128 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/139048 Apoptosis is a finely regulated process that serves to determine the fate of cells in response to various stresses. One such stress is DNA damage, which not only can signal repair processes but is also intimately involved in regulating cell fate. In this review we examine the relationship between the DNA damage/repair response in cell survival and apoptosis following insults to the DNA. Elucidating these pathways and the crosstalk between them is of great importance, as they eventually contribute to the etiology of human disease such as cancer and may play key roles in determining therapeutic response. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”. Some of the work described in this review was supported by the IMPACT Award from the Department of Radiation Oncology, University of Alabama-Birmingham Comprehensive Cancer Center, a translational scholar award from the Sidney Kimmel Foundation for cancer research, a pilot award from the Center for Clinical and Translational Science (CCTS) and the Council of Center Directors (COCD) Translational Research Intramural Pilot Grant Program (grant number 5UL1 RR025777-04) from the NIH National Center for Research Resources, and a medical research award from the Gabrielle’s Angel Foundation (to ESY). We recognize that we were unable to cover all aspects of DNA damage response and cell death pathways in this review. We apologize to those whom we have been unable to cite owing to space constraints. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Reviews The intersection between DNA damage response and cell death pathways Article published earlier |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| title |
The intersection between DNA damage response and cell death pathways |
| spellingShingle |
The intersection between DNA damage response and cell death pathways Nowsheen, S. Yang, E.S. Reviews |
| title_short |
The intersection between DNA damage response and cell death pathways |
| title_full |
The intersection between DNA damage response and cell death pathways |
| title_fullStr |
The intersection between DNA damage response and cell death pathways |
| title_full_unstemmed |
The intersection between DNA damage response and cell death pathways |
| title_sort |
intersection between dna damage response and cell death pathways |
| author |
Nowsheen, S. Yang, E.S. |
| author_facet |
Nowsheen, S. Yang, E.S. |
| topic |
Reviews |
| topic_facet |
Reviews |
| publishDate |
2012 |
| language |
English |
| container_title |
Experimental Oncology |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| format |
Article |
| description |
Apoptosis is a finely regulated process that serves to determine the fate of cells in response to various stresses. One such stress is DNA damage, which not only can signal repair processes but is also intimately involved in regulating cell fate. In this review we examine the relationship between the DNA damage/repair response in cell survival and apoptosis following insults to the DNA. Elucidating these pathways and the crosstalk between them is of great importance, as they eventually contribute to the etiology of human disease such as cancer and may play key roles in determining therapeutic response. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”.
|
| issn |
1812-9269 |
| url |
https://nasplib.isofts.kiev.ua/handle/123456789/139048 |
| citation_txt |
The intersection between DNA damage response and cell death pathways / S. Howsheen, E.S. Yang // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 243-254. — Бібліогр.: 128 назв. — англ. |
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2025-12-07T15:52:06Z |
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