The intersection between DNA damage response and cell death pathways
Apoptosis is a finely regulated process that serves to determine the fate of cells in response to various stresses. One such stress is DNA damage, which not only can signal repair processes but is also intimately involved in regulating cell fate. In this review we examine the relationship between th...
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| Veröffentlicht in: | Experimental Oncology |
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| Datum: | 2012 |
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | Englisch |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2012
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| Online Zugang: | https://nasplib.isofts.kiev.ua/handle/123456789/139048 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Zitieren: | The intersection between DNA damage response and cell death pathways / S. Howsheen, E.S. Yang // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 243-254. — Бібліогр.: 128 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862682236135931904 |
|---|---|
| author | Nowsheen, S. Yang, E.S. |
| author_facet | Nowsheen, S. Yang, E.S. |
| citation_txt | The intersection between DNA damage response and cell death pathways / S. Howsheen, E.S. Yang // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 243-254. — Бібліогр.: 128 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Apoptosis is a finely regulated process that serves to determine the fate of cells in response to various stresses. One such stress is DNA damage, which not only can signal repair processes but is also intimately involved in regulating cell fate. In this review we examine the relationship between the DNA damage/repair response in cell survival and apoptosis following insults to the DNA. Elucidating these pathways and the crosstalk between them is of great importance, as they eventually contribute to the etiology of human disease such as cancer and may play key roles in determining therapeutic response. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”.
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| first_indexed | 2025-12-07T15:52:06Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-139048 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-07T15:52:06Z |
| publishDate | 2012 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Nowsheen, S. Yang, E.S. 2018-06-19T18:46:37Z 2018-06-19T18:46:37Z 2012 The intersection between DNA damage response and cell death pathways / S. Howsheen, E.S. Yang // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 243-254. — Бібліогр.: 128 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/139048 Apoptosis is a finely regulated process that serves to determine the fate of cells in response to various stresses. One such stress is DNA damage, which not only can signal repair processes but is also intimately involved in regulating cell fate. In this review we examine the relationship between the DNA damage/repair response in cell survival and apoptosis following insults to the DNA. Elucidating these pathways and the crosstalk between them is of great importance, as they eventually contribute to the etiology of human disease such as cancer and may play key roles in determining therapeutic response. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”. Some of the work described in this review was
 supported by the IMPACT Award from the Department
 of Radiation Oncology, University of Alabama-Birmingham
 Comprehensive Cancer Center, a translational
 scholar award from the Sidney Kimmel Foundation
 for cancer research, a pilot award from the Center
 for Clinical and Translational Science (CCTS) and the
 Council of Center Directors (COCD) Translational Research
 Intramural Pilot Grant Program (grant number
 5UL1 RR025777-04) from the NIH National Center
 for Research Resources, and a medical research
 award from the Gabrielle’s Angel Foundation (to ESY).
 We recognize that we were unable to cover all aspects
 of DNA damage response and cell death pathways
 in this review. We apologize to those whom we have
 been unable to cite owing to space constraints. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Reviews The intersection between DNA damage response and cell death pathways Article published earlier |
| spellingShingle | The intersection between DNA damage response and cell death pathways Nowsheen, S. Yang, E.S. Reviews |
| title | The intersection between DNA damage response and cell death pathways |
| title_full | The intersection between DNA damage response and cell death pathways |
| title_fullStr | The intersection between DNA damage response and cell death pathways |
| title_full_unstemmed | The intersection between DNA damage response and cell death pathways |
| title_short | The intersection between DNA damage response and cell death pathways |
| title_sort | intersection between dna damage response and cell death pathways |
| topic | Reviews |
| topic_facet | Reviews |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/139048 |
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