Translation control in apoptosis
Regulation of protein synthesis, although known for many decades, has only recently begun to be recognized as a critical control mechanism for the maintenance of cellular homeostasis and cellular stress response. One of the key advantages of translational control is the ability of cells to rapidly r...
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| Veröffentlicht in: | Experimental Oncology |
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| Datum: | 2012 |
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| Format: | Artikel |
| Sprache: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2012
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| Zitieren: | Translation control in apoptosis / U. Liwak, M.D. Faye, M. Holcik // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 218-230. — Бібліогр.: 123 назв. — англ. |
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Liwak, U. Faye, M.D. Holcik, M. 2018-06-19T18:47:20Z 2018-06-19T18:47:20Z 2012 Translation control in apoptosis / U. Liwak, M.D. Faye, M. Holcik // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 218-230. — Бібліогр.: 123 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/139050 Regulation of protein synthesis, although known for many decades, has only recently begun to be recognized as a critical control mechanism for the maintenance of cellular homeostasis and cellular stress response. One of the key advantages of translational control is the ability of cells to rapidly reprogram the protein output in response to internal or external triggers. This is particularly important during cellular response to stress that may lead to apoptosis by providing cells with a fine tuning mechanism that tips the balance between cell survival or apoptosis. In the following review we highlight several distinct mechanisms of translation control and provide specific examples of translational control during apoptosis. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”. The work in the author’s laboratory is supported by operating grants from the Canadian Institutes of Health Research (CIHR; MOP 89737 and FRN74740) to M.H., an Ontario Graduate Scholarship to U.L. and the Vanier Canada Graduate Scholarship to M.D.F. M.H. is the CHEO Volunteer Association Endowed Scholar. The authors have no competing financial interests in relation to the work described in this manuscript. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Reviews Translation control in apoptosis Article published earlier |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| title |
Translation control in apoptosis |
| spellingShingle |
Translation control in apoptosis Liwak, U. Faye, M.D. Holcik, M. Reviews |
| title_short |
Translation control in apoptosis |
| title_full |
Translation control in apoptosis |
| title_fullStr |
Translation control in apoptosis |
| title_full_unstemmed |
Translation control in apoptosis |
| title_sort |
translation control in apoptosis |
| author |
Liwak, U. Faye, M.D. Holcik, M. |
| author_facet |
Liwak, U. Faye, M.D. Holcik, M. |
| topic |
Reviews |
| topic_facet |
Reviews |
| publishDate |
2012 |
| language |
English |
| container_title |
Experimental Oncology |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| format |
Article |
| description |
Regulation of protein synthesis, although known for many decades, has only recently begun to be recognized as a critical control mechanism for the maintenance of cellular homeostasis and cellular stress response. One of the key advantages of translational control is the ability of cells to rapidly reprogram the protein output in response to internal or external triggers. This is particularly important during cellular response to stress that may lead to apoptosis by providing cells with a fine tuning mechanism that tips the balance between cell survival or apoptosis. In the following review we highlight several distinct mechanisms of translation control and provide specific examples of translational control during apoptosis. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”.
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| issn |
1812-9269 |
| url |
https://nasplib.isofts.kiev.ua/handle/123456789/139050 |
| citation_txt |
Translation control in apoptosis / U. Liwak, M.D. Faye, M. Holcik // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 218-230. — Бібліогр.: 123 назв. — англ. |
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AT liwaku translationcontrolinapoptosis AT fayemd translationcontrolinapoptosis AT holcikm translationcontrolinapoptosis |
| first_indexed |
2025-11-30T10:39:50Z |
| last_indexed |
2025-11-30T10:39:50Z |
| _version_ |
1850857392388964352 |