Translation control in apoptosis
Regulation of protein synthesis, although known for many decades, has only recently begun to be recognized as a critical control mechanism for the maintenance of cellular homeostasis and cellular stress response. One of the key advantages of translational control is the ability of cells to rapidly r...
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| Published in: | Experimental Oncology |
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| Date: | 2012 |
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2012
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/139050 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Translation control in apoptosis / U. Liwak, M.D. Faye, M. Holcik // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 218-230. — Бібліогр.: 123 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862631027198918656 |
|---|---|
| author | Liwak, U. Faye, M.D. Holcik, M. |
| author_facet | Liwak, U. Faye, M.D. Holcik, M. |
| citation_txt | Translation control in apoptosis / U. Liwak, M.D. Faye, M. Holcik // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 218-230. — Бібліогр.: 123 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Regulation of protein synthesis, although known for many decades, has only recently begun to be recognized as a critical control mechanism for the maintenance of cellular homeostasis and cellular stress response. One of the key advantages of translational control is the ability of cells to rapidly reprogram the protein output in response to internal or external triggers. This is particularly important during cellular response to stress that may lead to apoptosis by providing cells with a fine tuning mechanism that tips the balance between cell survival or apoptosis. In the following review we highlight several distinct mechanisms of translation control and provide specific examples of translational control during apoptosis. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”.
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| first_indexed | 2025-11-30T10:39:50Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-139050 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-11-30T10:39:50Z |
| publishDate | 2012 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Liwak, U. Faye, M.D. Holcik, M. 2018-06-19T18:47:20Z 2018-06-19T18:47:20Z 2012 Translation control in apoptosis / U. Liwak, M.D. Faye, M. Holcik // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 218-230. — Бібліогр.: 123 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/139050 Regulation of protein synthesis, although known for many decades, has only recently begun to be recognized as a critical control mechanism for the maintenance of cellular homeostasis and cellular stress response. One of the key advantages of translational control is the ability of cells to rapidly reprogram the protein output in response to internal or external triggers. This is particularly important during cellular response to stress that may lead to apoptosis by providing cells with a fine tuning mechanism that tips the balance between cell survival or apoptosis. In the following review we highlight several distinct mechanisms of translation control and provide specific examples of translational control during apoptosis. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”. The work in the author’s laboratory is supported
 by operating grants from the Canadian Institutes
 of Health Research (CIHR; MOP 89737 and FRN74740)
 to M.H., an Ontario Graduate Scholarship to U.L. and
 the Vanier Canada Graduate Scholarship to M.D.F. M.H.
 is the CHEO Volunteer Association Endowed Scholar.
 The authors have no competing financial interests in relation
 to the work described in this manuscript. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Reviews Translation control in apoptosis Article published earlier |
| spellingShingle | Translation control in apoptosis Liwak, U. Faye, M.D. Holcik, M. Reviews |
| title | Translation control in apoptosis |
| title_full | Translation control in apoptosis |
| title_fullStr | Translation control in apoptosis |
| title_full_unstemmed | Translation control in apoptosis |
| title_short | Translation control in apoptosis |
| title_sort | translation control in apoptosis |
| topic | Reviews |
| topic_facet | Reviews |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/139050 |
| work_keys_str_mv | AT liwaku translationcontrolinapoptosis AT fayemd translationcontrolinapoptosis AT holcikm translationcontrolinapoptosis |