Cytometry of apoptosis. Historical perspective and new advances
Characteristic changes in cell morphology paralleled by the appearance of a multitude of molecular and biochemical markers occur during apoptosis. These changes vary depending on the cell type, mechanism of induction of apoptosis, and the time-window at which the process of apoptosis is analyzed. By...
Збережено в:
| Опубліковано в: : | Experimental Oncology |
|---|---|
| Дата: | 2012 |
| Автори: | , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2012
|
| Теми: | |
| Онлайн доступ: | https://nasplib.isofts.kiev.ua/handle/123456789/139051 |
| Теги: |
Додати тег
Немає тегів, Будьте першим, хто поставить тег для цього запису!
|
| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Cytometry of apoptosis. Historical perspective and new advances / D. Wlodkovic, J. Skommer, Z. Darzynkiewicz // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 255-262. — Бібліогр.: 78 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| id |
nasplib_isofts_kiev_ua-123456789-139051 |
|---|---|
| record_format |
dspace |
| spelling |
Wlodkowic, D. Skommer, J. Darzynkiewicz, Z. 2018-06-19T18:48:05Z 2018-06-19T18:48:05Z 2012 Cytometry of apoptosis. Historical perspective and new advances / D. Wlodkovic, J. Skommer, Z. Darzynkiewicz // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 255-262. — Бібліогр.: 78 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/139051 Characteristic changes in cell morphology paralleled by the appearance of a multitude of molecular and biochemical markers occur during apoptosis. These changes vary depending on the cell type, mechanism of induction of apoptosis, and the time-window at which the process of apoptosis is analyzed. By virtue of the capability of rapid measurement of individual cells the flow- and imaging-cytometry become preferred technologies to detect, identify and record incidence of apoptosis in large cell populations. It also provided a valuable tool to investigate molecular mechanisms in field of necrobiology. This review outlines the progress in development of the most commonly used cytometric methods probing cells death based on analysis of fragmentation of DNA, activation of caspases, analysis of mitochondrial potential, alterations in plasma membrane structure and other features that characterize programmed cell death. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later” Supported by NIH NCI RO1 28 704 and by the Robert Welke Foundation for Cancer Research (ZD); Faculty Research Development Fund, University of Auckland (DW); Early Career Research Excellence Award, University of Auckland (DW); NZ Foundation for Research Science and Technology (DW); NZ Neurological Foundation (JS). en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Reviews Cytometry of apoptosis. Historical perspective and new advances Article published earlier |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| title |
Cytometry of apoptosis. Historical perspective and new advances |
| spellingShingle |
Cytometry of apoptosis. Historical perspective and new advances Wlodkowic, D. Skommer, J. Darzynkiewicz, Z. Reviews |
| title_short |
Cytometry of apoptosis. Historical perspective and new advances |
| title_full |
Cytometry of apoptosis. Historical perspective and new advances |
| title_fullStr |
Cytometry of apoptosis. Historical perspective and new advances |
| title_full_unstemmed |
Cytometry of apoptosis. Historical perspective and new advances |
| title_sort |
cytometry of apoptosis. historical perspective and new advances |
| author |
Wlodkowic, D. Skommer, J. Darzynkiewicz, Z. |
| author_facet |
Wlodkowic, D. Skommer, J. Darzynkiewicz, Z. |
| topic |
Reviews |
| topic_facet |
Reviews |
| publishDate |
2012 |
| language |
English |
| container_title |
Experimental Oncology |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| format |
Article |
| description |
Characteristic changes in cell morphology paralleled by the appearance of a multitude of molecular and biochemical markers occur during apoptosis. These changes vary depending on the cell type, mechanism of induction of apoptosis, and the time-window at which the process of apoptosis is analyzed. By virtue of the capability of rapid measurement of individual cells the flow- and imaging-cytometry become preferred technologies to detect, identify and record incidence of apoptosis in large cell populations. It also provided a valuable tool to investigate molecular mechanisms in field of necrobiology. This review outlines the progress in development of the most commonly used cytometric methods probing cells death based on analysis of fragmentation of DNA, activation of caspases, analysis of mitochondrial potential, alterations in plasma membrane structure and other features that characterize programmed cell death. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”
|
| issn |
1812-9269 |
| url |
https://nasplib.isofts.kiev.ua/handle/123456789/139051 |
| citation_txt |
Cytometry of apoptosis. Historical perspective and new advances / D. Wlodkovic, J. Skommer, Z. Darzynkiewicz // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 255-262. — Бібліогр.: 78 назв. — англ. |
| work_keys_str_mv |
AT wlodkowicd cytometryofapoptosishistoricalperspectiveandnewadvances AT skommerj cytometryofapoptosishistoricalperspectiveandnewadvances AT darzynkiewiczz cytometryofapoptosishistoricalperspectiveandnewadvances |
| first_indexed |
2025-11-28T13:51:02Z |
| last_indexed |
2025-11-28T13:51:02Z |
| _version_ |
1850853744863870976 |