Sphingolipids in Apoptosis
Forty years ago, the term “apoptosis” was introduced to describe a form of programmed cell death. Key players that mediate apoptosis at the molecular level such as caspases, death receptors, Bcl-2 family members have since been identified and their regulation remains a research focus of many laborat...
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| Опубліковано в: : | Experimental Oncology |
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| Дата: | 2012 |
| Автори: | , |
| Формат: | Стаття |
| Мова: | Англійська |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2012
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| Онлайн доступ: | https://nasplib.isofts.kiev.ua/handle/123456789/139053 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Sphingolipids in Apoptosis / T.S. Tirodkar, C. Voekel-Johnson // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 231-242. — Бібліогр.: 152 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862725970043076608 |
|---|---|
| author | Tirodkar, T.S. Voelkel-Johnson, C. |
| author_facet | Tirodkar, T.S. Voelkel-Johnson, C. |
| citation_txt | Sphingolipids in Apoptosis / T.S. Tirodkar, C. Voekel-Johnson // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 231-242. — Бібліогр.: 152 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Forty years ago, the term “apoptosis” was introduced to describe a form of programmed cell death. Key players that mediate apoptosis at the molecular level such as caspases, death receptors, Bcl-2 family members have since been identified and their regulation remains a research focus of many laboratories. In 1993, approximately 20 years after the introduction of apoptosis, the sphingolipid ceramide was first linked to this form of cell death. Sphingolipids are bioactive components of cellular membranes that are involved in numerous physiological functions. In this paper, we discuss the inherent complexities of sphingolipid signaling and elaborate on how sphingolipids, primarily ceramide, influence apoptotic events such as death receptor aggregation in the plasma membrane and pore formation at the mitochondria. Possible roles of sphingolipids in other subcellular compartments, such as the nucleus, endoplasmic reticulum and lysosomes are also discussed. We conclude by summarizing the recent developments in sphingolipid based cancer therapy. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”.
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| first_indexed | 2025-12-07T18:55:07Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-139053 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-07T18:55:07Z |
| publishDate | 2012 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Tirodkar, T.S. Voelkel-Johnson, C. 2018-06-19T18:49:40Z 2018-06-19T18:49:40Z 2012 Sphingolipids in Apoptosis / T.S. Tirodkar, C. Voekel-Johnson // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 231-242. — Бібліогр.: 152 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/139053 Forty years ago, the term “apoptosis” was introduced to describe a form of programmed cell death. Key players that mediate apoptosis at the molecular level such as caspases, death receptors, Bcl-2 family members have since been identified and their regulation remains a research focus of many laboratories. In 1993, approximately 20 years after the introduction of apoptosis, the sphingolipid ceramide was first linked to this form of cell death. Sphingolipids are bioactive components of cellular membranes that are involved in numerous physiological functions. In this paper, we discuss the inherent complexities of sphingolipid signaling and elaborate on how sphingolipids, primarily ceramide, influence apoptotic events such as death receptor aggregation in the plasma membrane and pore formation at the mitochondria. Possible roles of sphingolipids in other subcellular compartments, such as the nucleus, endoplasmic reticulum and lysosomes are also discussed. We conclude by summarizing the recent developments in sphingolipid based cancer therapy. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Reviews Sphingolipids in Apoptosis Article published earlier |
| spellingShingle | Sphingolipids in Apoptosis Tirodkar, T.S. Voelkel-Johnson, C. Reviews |
| title | Sphingolipids in Apoptosis |
| title_full | Sphingolipids in Apoptosis |
| title_fullStr | Sphingolipids in Apoptosis |
| title_full_unstemmed | Sphingolipids in Apoptosis |
| title_short | Sphingolipids in Apoptosis |
| title_sort | sphingolipids in apoptosis |
| topic | Reviews |
| topic_facet | Reviews |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/139053 |
| work_keys_str_mv | AT tirodkarts sphingolipidsinapoptosis AT voelkeljohnsonc sphingolipidsinapoptosis |