Accelerated cellular senescence in solid tumor therapy
Accelerated cellular senescence (ACS) is an emerging concept that implicates sustained, telomere-independent cell cycle arrest of neoplastic cells in response to chemotherapeutic agents, ionizing radiation, oxidative stress, or the presence of selective oncogenic stimuli. Recent evidence suggests th...
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| Published in: | Experimental Oncology |
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| Date: | 2012 |
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2012
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/139056 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Accelerated cellular senescence in solid tumor therapy / P.C. Wu, Q. Wang, L. Grobman, E. Chu, D.Y. Wu // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 298-305. — Бібліогр.: 85 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862635674226655232 |
|---|---|
| author | Wu, P.C. Wang, Q. Grobman, L. Chu, E. Wu, D.Y. |
| author_facet | Wu, P.C. Wang, Q. Grobman, L. Chu, E. Wu, D.Y. |
| citation_txt | Accelerated cellular senescence in solid tumor therapy / P.C. Wu, Q. Wang, L. Grobman, E. Chu, D.Y. Wu // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 298-305. — Бібліогр.: 85 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Accelerated cellular senescence (ACS) is an emerging concept that implicates sustained, telomere-independent cell cycle arrest of neoplastic cells in response to chemotherapeutic agents, ionizing radiation, oxidative stress, or the presence of selective oncogenic stimuli. Recent evidence suggests that a subset of tumor cells induced in a state of reversible ACS can escape cell cycle arrest and resume proliferation accounting for cancer progression. The purpose of this review is to describe our current understanding of ACS including signaling pathways of senescence escape, role of senescence biomarkers, and rationale for senescence-based therapy. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”.
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| first_indexed | 2025-11-30T19:03:30Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-139056 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-11-30T19:03:30Z |
| publishDate | 2012 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Wu, P.C. Wang, Q. Grobman, L. Chu, E. Wu, D.Y. 2018-06-19T18:53:53Z 2018-06-19T18:53:53Z 2012 Accelerated cellular senescence in solid tumor therapy / P.C. Wu, Q. Wang, L. Grobman, E. Chu, D.Y. Wu // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 298-305. — Бібліогр.: 85 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/139056 Accelerated cellular senescence (ACS) is an emerging concept that implicates sustained, telomere-independent cell cycle arrest of neoplastic cells in response to chemotherapeutic agents, ionizing radiation, oxidative stress, or the presence of selective oncogenic stimuli. Recent evidence suggests that a subset of tumor cells induced in a state of reversible ACS can escape cell cycle arrest and resume proliferation accounting for cancer progression. The purpose of this review is to describe our current understanding of ACS including signaling pathways of senescence escape, role of senescence biomarkers, and rationale for senescence-based therapy. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Reviews Accelerated cellular senescence in solid tumor therapy Article published earlier |
| spellingShingle | Accelerated cellular senescence in solid tumor therapy Wu, P.C. Wang, Q. Grobman, L. Chu, E. Wu, D.Y. Reviews |
| title | Accelerated cellular senescence in solid tumor therapy |
| title_full | Accelerated cellular senescence in solid tumor therapy |
| title_fullStr | Accelerated cellular senescence in solid tumor therapy |
| title_full_unstemmed | Accelerated cellular senescence in solid tumor therapy |
| title_short | Accelerated cellular senescence in solid tumor therapy |
| title_sort | accelerated cellular senescence in solid tumor therapy |
| topic | Reviews |
| topic_facet | Reviews |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/139056 |
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