Caspase Control: Protagonists of Cancer Cell Apoptosis
Emergence of castration-resistant metastatic prostate cancer is due to activation of survival pathways, including apoptosis suppression and anoikis resistance, and increased neovascularization. Thus targeting of apoptotic players is of critical significance in prostate cancer therapy since loss of a...
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| Published in: | Experimental Oncology |
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| Date: | 2012 |
| Main Authors: | , |
| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2012
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/139061 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Caspase Control: Protagonists of Cancer Cell Apoptosis / M.V. Fiandalo, N. Kyprianou // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 165-175. — Бібліогр.: 150 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862615773762027520 |
|---|---|
| author | Fiandalo, M.V. Kyprianou, N. |
| author_facet | Fiandalo, M.V. Kyprianou, N. |
| citation_txt | Caspase Control: Protagonists of Cancer Cell Apoptosis / M.V. Fiandalo, N. Kyprianou // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 165-175. — Бібліогр.: 150 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Emergence of castration-resistant metastatic prostate cancer is due to activation of survival pathways, including apoptosis suppression and anoikis resistance, and increased neovascularization. Thus targeting of apoptotic players is of critical significance in prostate cancer therapy since loss of apoptosis and resistance to anoikis are critical in aberrant malignant growth, metastasis and conferring therapeutic failure. The majority of therapeutic agents act through intrinsic mitochondrial, extrinsic death receptor pathways or endoplasmic reticulum stress pathways to induce apoptosis. Current therapeutic strategies target restoring regulatory molecules that govern the pro-survival pathways such as PTEN which regulates AKT activity. Other strategies focus on reactivating the apoptotic pathways either by down-regulating anti-apoptotic players such as BCL-2 or by up-regulating pro-apoptotic protein families, most notably, the caspases. Caspases are a family of cystine proteases which serve critical roles in apoptotic and inflammatory signaling pathways. During tumorigenesis, significant loss or inactivation of lead members in the caspase family leads to impairing apoptosis induction, causing a dramatic imbalance in the growth dynamics, ultimately resulting in aberrant growth of human cancers. Recent exploitation of apoptosis pathways towards re-instating apoptosis induction via caspase re-activation has provided new molecular platforms for the development of therapeutic strategies effective against advanced prostate cancer as well as other solid tumors. This review will discuss the current cellular landscape featuring the caspase family in tumor cells and their activation via pharmacologic intervention towards optimized anti-cancer therapeutic modalities. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”.
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| first_indexed | 2025-11-29T13:21:45Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-139061 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-11-29T13:21:45Z |
| publishDate | 2012 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Fiandalo, M.V. Kyprianou, N. 2018-06-19T18:54:53Z 2018-06-19T18:54:53Z 2012 Caspase Control: Protagonists of Cancer Cell Apoptosis / M.V. Fiandalo, N. Kyprianou // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 165-175. — Бібліогр.: 150 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/139061 Emergence of castration-resistant metastatic prostate cancer is due to activation of survival pathways, including apoptosis suppression and anoikis resistance, and increased neovascularization. Thus targeting of apoptotic players is of critical significance in prostate cancer therapy since loss of apoptosis and resistance to anoikis are critical in aberrant malignant growth, metastasis and conferring therapeutic failure. The majority of therapeutic agents act through intrinsic mitochondrial, extrinsic death receptor pathways or endoplasmic reticulum stress pathways to induce apoptosis. Current therapeutic strategies target restoring regulatory molecules that govern the pro-survival pathways such as PTEN which regulates AKT activity. Other strategies focus on reactivating the apoptotic pathways either by down-regulating anti-apoptotic players such as BCL-2 or by up-regulating pro-apoptotic protein families, most notably, the caspases. Caspases are a family of cystine proteases which serve critical roles in apoptotic and inflammatory signaling pathways. During tumorigenesis, significant loss or inactivation of lead members in the caspase family leads to impairing apoptosis induction, causing a dramatic imbalance in the growth dynamics, ultimately resulting in aberrant growth of human cancers. Recent exploitation of apoptosis pathways towards re-instating apoptosis induction via caspase re-activation has provided new molecular platforms for the development of therapeutic strategies effective against advanced prostate cancer as well as other solid tumors. This review will discuss the current cellular landscape featuring the caspase family in tumor cells and their activation via pharmacologic intervention towards optimized anti-cancer therapeutic modalities. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”. The authors wish to acknowledge Drs. Steven
 Schwarze, Vivek Rangnekar and Stephen Strup for
 useful discussions and the administrative assistance
 of Lorie Howard. The studies have been supported
 by grants from the Department of Defense (USAMRMC
 PC073314), the James F. Hardymon Endowment at the
 University of Kentucky College of Medicine and the
 Markey Cancer Foundation. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Reviews Caspase Control: Protagonists of Cancer Cell Apoptosis Article published earlier |
| spellingShingle | Caspase Control: Protagonists of Cancer Cell Apoptosis Fiandalo, M.V. Kyprianou, N. Reviews |
| title | Caspase Control: Protagonists of Cancer Cell Apoptosis |
| title_full | Caspase Control: Protagonists of Cancer Cell Apoptosis |
| title_fullStr | Caspase Control: Protagonists of Cancer Cell Apoptosis |
| title_full_unstemmed | Caspase Control: Protagonists of Cancer Cell Apoptosis |
| title_short | Caspase Control: Protagonists of Cancer Cell Apoptosis |
| title_sort | caspase control: protagonists of cancer cell apoptosis |
| topic | Reviews |
| topic_facet | Reviews |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/139061 |
| work_keys_str_mv | AT fiandalomv caspasecontrolprotagonistsofcancercellapoptosis AT kyprianoun caspasecontrolprotagonistsofcancercellapoptosis |