Targeting the anti-apoptotic BCL-2 family members for the treatment of cancer
Most cells express a variety of both anti-apoptotic and pro-apoptotic Bcl-2 proteins and the interaction within this family dictates whether a cell survives or dies. The dysregulation of the anti-anti-apoptotic Bcl-2 family members is one of the defining features of cancer cells in comparison to nor...
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| Published in: | Experimental Oncology |
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| Date: | 2012 |
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2012
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/139083 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Targeting the anti-apoptotic BCL-2 family members for the treatment of cancer / B. Weyhenmeyer, A.C. Murphy, J.H.M. Prehn, B.M. Murphy // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 192-199. — Бібліогр.: 108 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| id |
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Weyhenmeyer, B. Murphy, A.C. Prehn, J.H.M. Murphy, B.M. 2018-06-19T19:02:32Z 2018-06-19T19:02:32Z 2012 Targeting the anti-apoptotic BCL-2 family members for the treatment of cancer / B. Weyhenmeyer, A.C. Murphy, J.H.M. Prehn, B.M. Murphy // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 192-199. — Бібліогр.: 108 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/139083 Most cells express a variety of both anti-apoptotic and pro-apoptotic Bcl-2 proteins and the interaction within this family dictates whether a cell survives or dies. The dysregulation of the anti-anti-apoptotic Bcl-2 family members is one of the defining features of cancer cells in comparison to normal cells, and significantly contributes to the resistance of cancer cells to current treatment modalities. This anti-apoptotic subfamily of proteins is now a major target in the development of new methods to improve treatment outcomes for cancer patients. Several drugs directed at inhibiting Bcl-2 and related anti-apoptotic proteins have been developed with some showing considerable promise in the clinic. This Review presents the current knowledge of the role of the anti-apoptotic Bcl-2 family in cancer cells, as well as current and future perspectives on targeting this subfamily of proteins for therapeutic intervention in human malignancies. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”. We thank our colleagues, Caoimhin Concannon and Sean Kilbride for their helpful comments in the preparation of this review. This research was generously supported by grants from the Health Research Board (RP/2008/69) and the RCSI Research Committee (GR 08-0155) to BMM. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Reviews Targeting the anti-apoptotic BCL-2 family members for the treatment of cancer Article published earlier |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine |
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DSpace DC |
| title |
Targeting the anti-apoptotic BCL-2 family members for the treatment of cancer |
| spellingShingle |
Targeting the anti-apoptotic BCL-2 family members for the treatment of cancer Weyhenmeyer, B. Murphy, A.C. Prehn, J.H.M. Murphy, B.M. Reviews |
| title_short |
Targeting the anti-apoptotic BCL-2 family members for the treatment of cancer |
| title_full |
Targeting the anti-apoptotic BCL-2 family members for the treatment of cancer |
| title_fullStr |
Targeting the anti-apoptotic BCL-2 family members for the treatment of cancer |
| title_full_unstemmed |
Targeting the anti-apoptotic BCL-2 family members for the treatment of cancer |
| title_sort |
targeting the anti-apoptotic bcl-2 family members for the treatment of cancer |
| author |
Weyhenmeyer, B. Murphy, A.C. Prehn, J.H.M. Murphy, B.M. |
| author_facet |
Weyhenmeyer, B. Murphy, A.C. Prehn, J.H.M. Murphy, B.M. |
| topic |
Reviews |
| topic_facet |
Reviews |
| publishDate |
2012 |
| language |
English |
| container_title |
Experimental Oncology |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| format |
Article |
| description |
Most cells express a variety of both anti-apoptotic and pro-apoptotic Bcl-2 proteins and the interaction within this family dictates whether a cell survives or dies. The dysregulation of the anti-anti-apoptotic Bcl-2 family members is one of the defining features of cancer cells in comparison to normal cells, and significantly contributes to the resistance of cancer cells to current treatment modalities. This anti-apoptotic subfamily of proteins is now a major target in the development of new methods to improve treatment outcomes for cancer patients. Several drugs directed at inhibiting Bcl-2 and related anti-apoptotic proteins have been developed with some showing considerable promise in the clinic. This Review presents the current knowledge of the role of the anti-apoptotic Bcl-2 family in cancer cells, as well as current and future perspectives on targeting this subfamily of proteins for therapeutic intervention in human malignancies. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”.
|
| issn |
1812-9269 |
| url |
https://nasplib.isofts.kiev.ua/handle/123456789/139083 |
| citation_txt |
Targeting the anti-apoptotic BCL-2 family members for the treatment of cancer / B. Weyhenmeyer, A.C. Murphy, J.H.M. Prehn, B.M. Murphy // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 192-199. — Бібліогр.: 108 назв. — англ. |
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| first_indexed |
2025-12-07T13:36:43Z |
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2025-12-07T13:36:43Z |
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