Targeting the anti-apoptotic BCL-2 family members for the treatment of cancer

• Published in: Experimental Oncology
• Date: 2012
• Main Authors: Weyhenmeyer, B., Murphy, A.C., Prehn, J.H.M., Murphy, B.M.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2012
• Subjects: Reviews
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/139083
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Targeting the anti-apoptotic BCL-2 family members for the treatment of cancer / B. Weyhenmeyer, A.C. Murphy, J.H.M. Prehn, B.M. Murphy // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 192-199. — Бібліогр.: 108 назв. — англ.

Most cells express a variety of both anti-apoptotic and pro-apoptotic Bcl-2 proteins and the interaction within this family dictates whether a cell survives or dies. The dysregulation of the anti-anti-apoptotic Bcl-2 family members is one of the defining features of cancer cells in comparison to nor...