Splice variants in apoptotic pathway

Splice variants in apoptotic pathway

Elimination of superfluous or mutated somatic cells is provided by various mechanisms including apoptosis, and deregulation of apoptotic signaling pathways contributes to oncogenesis. 40 years have passed since the term “apoptosis” was introduced by Kerr et al. in 1972; among the programmed cell dea...

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Published in:Experimental Oncology
Date:2012
Main Authors: Miura, K., Fujibuchi, W., Unno, M.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2012
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Reviews
Online Access:https://nasplib.isofts.kiev.ua/handle/123456789/139085
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Journal Title:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Cite this:Splice variants in apoptotic pathway / K. Miura, W. Fujibuchi, M. Unno // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 212-217. — Бібліогр.: 71 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-139085
record_format dspace
spelling Miura, K.
Fujibuchi, W.
Unno, M.
2018-06-19T19:03:43Z
2018-06-19T19:03:43Z
2012
Splice variants in apoptotic pathway / K. Miura, W. Fujibuchi, M. Unno // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 212-217. — Бібліогр.: 71 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/139085
Elimination of superfluous or mutated somatic cells is provided by various mechanisms including apoptosis, and deregulation of apoptotic signaling pathways contributes to oncogenesis. 40 years have passed since the term “apoptosis” was introduced by Kerr et al. in 1972; among the programmed cell death, a variety of therapeutic strategies especially targeting apoptotic pathways have been investigated. Alternative precursor messenger RNA splicing, by which the process the exons of pre-mRNA are spliced in different arrangements to produce structurally and functionally distinct mRNA and proteins, is another field in progress, and it has been recognized as one of the most important mechanisms that maintains genomic and functional diversity. A variety of apoptotic genes are regulated through alternative pre-mRNA splicing as well, some of which have important functions as pro-apoptotic and anti-apoptotic factors. In this article we summarized splice variants of some of the apoptotic genes including BCL2L1, BIRC5, CFLAR, and MADD, as well as the regulatory mechanisms of alternative splicing of these genes. If the information of the apoptosis and aberrant splicing in each of malignancies is integrated, it will become possible to target proper variants for apoptosis, and the trans-elements themselves can become specific targets of cancer therapy as well. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”.
The authors would appreciate this opportunity to submit our work to the Special Issue of Experimental Oncology (National Academy of Sciences of Ukraine).
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Reviews
Splice variants in apoptotic pathway
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title Splice variants in apoptotic pathway
spellingShingle Splice variants in apoptotic pathway
Miura, K.
Fujibuchi, W.
Unno, M.
Reviews
title_short Splice variants in apoptotic pathway
title_full Splice variants in apoptotic pathway
title_fullStr Splice variants in apoptotic pathway
title_full_unstemmed Splice variants in apoptotic pathway
title_sort splice variants in apoptotic pathway
author Miura, K.
Fujibuchi, W.
Unno, M.
author_facet Miura, K.
Fujibuchi, W.
Unno, M.
topic Reviews
topic_facet Reviews
publishDate 2012
language English
container_title Experimental Oncology
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
format Article
description Elimination of superfluous or mutated somatic cells is provided by various mechanisms including apoptosis, and deregulation of apoptotic signaling pathways contributes to oncogenesis. 40 years have passed since the term “apoptosis” was introduced by Kerr et al. in 1972; among the programmed cell death, a variety of therapeutic strategies especially targeting apoptotic pathways have been investigated. Alternative precursor messenger RNA splicing, by which the process the exons of pre-mRNA are spliced in different arrangements to produce structurally and functionally distinct mRNA and proteins, is another field in progress, and it has been recognized as one of the most important mechanisms that maintains genomic and functional diversity. A variety of apoptotic genes are regulated through alternative pre-mRNA splicing as well, some of which have important functions as pro-apoptotic and anti-apoptotic factors. In this article we summarized splice variants of some of the apoptotic genes including BCL2L1, BIRC5, CFLAR, and MADD, as well as the regulatory mechanisms of alternative splicing of these genes. If the information of the apoptosis and aberrant splicing in each of malignancies is integrated, it will become possible to target proper variants for apoptosis, and the trans-elements themselves can become specific targets of cancer therapy as well. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”.
issn 1812-9269
url https://nasplib.isofts.kiev.ua/handle/123456789/139085
citation_txt Splice variants in apoptotic pathway / K. Miura, W. Fujibuchi, M. Unno // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 212-217. — Бібліогр.: 71 назв. — англ.
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first_indexed 2025-11-30T10:11:13Z
last_indexed 2025-11-30T10:11:13Z
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