Activity of thymidilate «salvage pathway» enzymes in human gastric cancer and blood serum: correlation with treatment modalities
A comparative study of enzyme activity features of thymidilate “salvage pathway” synthesis in blood serum and tissues of different age patients with gastric cancer (T3–4N0-xM0) was carried out. Aim: To evaluate the diagnostic relevance of thymidilate metabolism enzymes activities and their associati...
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| Published in: | Experimental Oncology |
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| Date: | 2013 |
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2013
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/139124 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Activity of thymidilate «salvage pathway» enzymes in human gastric cancer and blood serum: correlation with treatment modalities / B.G. Borzenko, E.M. Bakurova, Yu.A. Popovich, E.A. Sidyuk, A.Y. Popovich // Experimental Oncology. — 2013. — Т. 35, № 1. — С. 37-40. — Бібліогр.: 12 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862609478730383360 |
|---|---|
| author | Borzenko, B.G. Bakurova, E.M. Popovich, Yu.A. Sidyuk, E.A. Popovich, A.Y. |
| author_facet | Borzenko, B.G. Bakurova, E.M. Popovich, Yu.A. Sidyuk, E.A. Popovich, A.Y. |
| citation_txt | Activity of thymidilate «salvage pathway» enzymes in human gastric cancer and blood serum: correlation with treatment modalities / B.G. Borzenko, E.M. Bakurova, Yu.A. Popovich, E.A. Sidyuk, A.Y. Popovich // Experimental Oncology. — 2013. — Т. 35, № 1. — С. 37-40. — Бібліогр.: 12 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | A comparative study of enzyme activity features of thymidilate “salvage pathway” synthesis in blood serum and tissues of different age patients with gastric cancer (T3–4N0-xM0) was carried out. Aim: To evaluate the diagnostic relevance of thymidilate metabolism enzymes activities and their association with tumor growth. Methods: Enzymes activities were determined by the radioisotope method and spectrophotometrically in tumor tissues and blood serum of 74 patients. Results: It was demonstrated that thymidine phosphorylase activity in gastric tumors is lower by 2.6 times as compared to non-neoplastic mucosa of resection margin. This being accompanied by decrease of its activity in the blood serum (from 47.9 ± 2.6 to 14.65 ± 2.4 nmol/min·mg, p < 0.001). An increase of thymidine kinase activity was revealed both in tumor tissues (more than 3.5 times) and in blood serum (from 3.9 ± 0,7 nmol/mg·h, to 6.8 ± 1.0 nmol/mg·h, p < 0.01). Changes in their activity in the postoperative period depended on the type of surgical procedure and tumor eradication. Conclusion: It could be suggested that control of individual dynamics of the enzymes activities in blood serum may be used as informative tool for monitoring of patients and treatment optimization.
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| first_indexed | 2025-11-28T18:42:43Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-139124 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-11-28T18:42:43Z |
| publishDate | 2013 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Borzenko, B.G. Bakurova, E.M. Popovich, Yu.A. Sidyuk, E.A. Popovich, A.Y. 2018-06-19T19:18:00Z 2018-06-19T19:18:00Z 2013 Activity of thymidilate «salvage pathway» enzymes in human gastric cancer and blood serum: correlation with treatment modalities / B.G. Borzenko, E.M. Bakurova, Yu.A. Popovich, E.A. Sidyuk, A.Y. Popovich // Experimental Oncology. — 2013. — Т. 35, № 1. — С. 37-40. — Бібліогр.: 12 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/139124 A comparative study of enzyme activity features of thymidilate “salvage pathway” synthesis in blood serum and tissues of different age patients with gastric cancer (T3–4N0-xM0) was carried out. Aim: To evaluate the diagnostic relevance of thymidilate metabolism enzymes activities and their association with tumor growth. Methods: Enzymes activities were determined by the radioisotope method and spectrophotometrically in tumor tissues and blood serum of 74 patients. Results: It was demonstrated that thymidine phosphorylase activity in gastric tumors is lower by 2.6 times as compared to non-neoplastic mucosa of resection margin. This being accompanied by decrease of its activity in the blood serum (from 47.9 ± 2.6 to 14.65 ± 2.4 nmol/min·mg, p < 0.001). An increase of thymidine kinase activity was revealed both in tumor tissues (more than 3.5 times) and in blood serum (from 3.9 ± 0,7 nmol/mg·h, to 6.8 ± 1.0 nmol/mg·h, p < 0.01). Changes in their activity in the postoperative period depended on the type of surgical procedure and tumor eradication. Conclusion: It could be suggested that control of individual dynamics of the enzymes activities in blood serum may be used as informative tool for monitoring of patients and treatment optimization. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Activity of thymidilate «salvage pathway» enzymes in human gastric cancer and blood serum: correlation with treatment modalities Article published earlier |
| spellingShingle | Activity of thymidilate «salvage pathway» enzymes in human gastric cancer and blood serum: correlation with treatment modalities Borzenko, B.G. Bakurova, E.M. Popovich, Yu.A. Sidyuk, E.A. Popovich, A.Y. Original contributions |
| title | Activity of thymidilate «salvage pathway» enzymes in human gastric cancer and blood serum: correlation with treatment modalities |
| title_full | Activity of thymidilate «salvage pathway» enzymes in human gastric cancer and blood serum: correlation with treatment modalities |
| title_fullStr | Activity of thymidilate «salvage pathway» enzymes in human gastric cancer and blood serum: correlation with treatment modalities |
| title_full_unstemmed | Activity of thymidilate «salvage pathway» enzymes in human gastric cancer and blood serum: correlation with treatment modalities |
| title_short | Activity of thymidilate «salvage pathway» enzymes in human gastric cancer and blood serum: correlation with treatment modalities |
| title_sort | activity of thymidilate «salvage pathway» enzymes in human gastric cancer and blood serum: correlation with treatment modalities |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/139124 |
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