Activity of thymidilate «salvage pathway» enzymes in human gastric cancer and blood serum: correlation with treatment modalities

Activity of thymidilate «salvage pathway» enzymes in human gastric cancer and blood serum: correlation with treatment modalities

A comparative study of enzyme activity features of thymidilate “salvage pathway” synthesis in blood serum and tissues of different age patients with gastric cancer (T3–4N0-xM0) was carried out. Aim: To evaluate the diagnostic relevance of thymidilate metabolism enzymes activities and their associati...

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Опубліковано в: :Experimental Oncology
Дата:2013
Автори: Borzenko, B.G., Bakurova, E.M., Popovich, Yu.A., Sidyuk, E.A., Popovich, A.Y.
Формат: Стаття
Мова:English
Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2013
Теми:
Original contributions
Онлайн доступ:https://nasplib.isofts.kiev.ua/handle/123456789/139124
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Цитувати:Activity of thymidilate «salvage pathway» enzymes in human gastric cancer and blood serum: correlation with treatment modalities / B.G. Borzenko, E.M. Bakurova, Yu.A. Popovich, E.A. Sidyuk, A.Y. Popovich // Experimental Oncology. — 2013. — Т. 35, № 1. — С. 37-40. — Бібліогр.: 12 назв. — англ.

Репозитарії

Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-139124
record_format dspace
spelling Borzenko, B.G.
Bakurova, E.M.
Popovich, Yu.A.
Sidyuk, E.A.
Popovich, A.Y.
2018-06-19T19:18:00Z
2018-06-19T19:18:00Z
2013
Activity of thymidilate «salvage pathway» enzymes in human gastric cancer and blood serum: correlation with treatment modalities / B.G. Borzenko, E.M. Bakurova, Yu.A. Popovich, E.A. Sidyuk, A.Y. Popovich // Experimental Oncology. — 2013. — Т. 35, № 1. — С. 37-40. — Бібліогр.: 12 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/139124
A comparative study of enzyme activity features of thymidilate “salvage pathway” synthesis in blood serum and tissues of different age patients with gastric cancer (T3–4N0-xM0) was carried out. Aim: To evaluate the diagnostic relevance of thymidilate metabolism enzymes activities and their association with tumor growth. Methods: Enzymes activities were determined by the radioisotope method and spectrophotometrically in tumor tissues and blood serum of 74 patients. Results: It was demonstrated that thymidine phosphorylase activity in gastric tumors is lower by 2.6 times as compared to non-neoplastic mucosa of resection margin. This being accompanied by decrease of its activity in the blood serum (from 47.9 ± 2.6 to 14.65 ± 2.4 nmol/min·mg, p < 0.001). An increase of thymidine kinase activity was revealed both in tumor tissues (more than 3.5 times) and in blood serum (from 3.9 ± 0,7 nmol/mg·h, to 6.8 ± 1.0 nmol/mg·h, p < 0.01). Changes in their activity in the postoperative period depended on the type of surgical procedure and tumor eradication. Conclusion: It could be suggested that control of individual dynamics of the enzymes activities in blood serum may be used as informative tool for monitoring of patients and treatment optimization.
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Original contributions
Activity of thymidilate «salvage pathway» enzymes in human gastric cancer and blood serum: correlation with treatment modalities
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title Activity of thymidilate «salvage pathway» enzymes in human gastric cancer and blood serum: correlation with treatment modalities
spellingShingle Activity of thymidilate «salvage pathway» enzymes in human gastric cancer and blood serum: correlation with treatment modalities
Borzenko, B.G.
Bakurova, E.M.
Popovich, Yu.A.
Sidyuk, E.A.
Popovich, A.Y.
Original contributions
title_short Activity of thymidilate «salvage pathway» enzymes in human gastric cancer and blood serum: correlation with treatment modalities
title_full Activity of thymidilate «salvage pathway» enzymes in human gastric cancer and blood serum: correlation with treatment modalities
title_fullStr Activity of thymidilate «salvage pathway» enzymes in human gastric cancer and blood serum: correlation with treatment modalities
title_full_unstemmed Activity of thymidilate «salvage pathway» enzymes in human gastric cancer and blood serum: correlation with treatment modalities
title_sort activity of thymidilate «salvage pathway» enzymes in human gastric cancer and blood serum: correlation with treatment modalities
author Borzenko, B.G.
Bakurova, E.M.
Popovich, Yu.A.
Sidyuk, E.A.
Popovich, A.Y.
author_facet Borzenko, B.G.
Bakurova, E.M.
Popovich, Yu.A.
Sidyuk, E.A.
Popovich, A.Y.
topic Original contributions
topic_facet Original contributions
publishDate 2013
language English
container_title Experimental Oncology
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
format Article
description A comparative study of enzyme activity features of thymidilate “salvage pathway” synthesis in blood serum and tissues of different age patients with gastric cancer (T3–4N0-xM0) was carried out. Aim: To evaluate the diagnostic relevance of thymidilate metabolism enzymes activities and their association with tumor growth. Methods: Enzymes activities were determined by the radioisotope method and spectrophotometrically in tumor tissues and blood serum of 74 patients. Results: It was demonstrated that thymidine phosphorylase activity in gastric tumors is lower by 2.6 times as compared to non-neoplastic mucosa of resection margin. This being accompanied by decrease of its activity in the blood serum (from 47.9 ± 2.6 to 14.65 ± 2.4 nmol/min·mg, p < 0.001). An increase of thymidine kinase activity was revealed both in tumor tissues (more than 3.5 times) and in blood serum (from 3.9 ± 0,7 nmol/mg·h, to 6.8 ± 1.0 nmol/mg·h, p < 0.01). Changes in their activity in the postoperative period depended on the type of surgical procedure and tumor eradication. Conclusion: It could be suggested that control of individual dynamics of the enzymes activities in blood serum may be used as informative tool for monitoring of patients and treatment optimization.
issn 1812-9269
url https://nasplib.isofts.kiev.ua/handle/123456789/139124
citation_txt Activity of thymidilate «salvage pathway» enzymes in human gastric cancer and blood serum: correlation with treatment modalities / B.G. Borzenko, E.M. Bakurova, Yu.A. Popovich, E.A. Sidyuk, A.Y. Popovich // Experimental Oncology. — 2013. — Т. 35, № 1. — С. 37-40. — Бібліогр.: 12 назв. — англ.
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AT popovichyua activityofthymidilatesalvagepathwayenzymesinhumangastriccancerandbloodserumcorrelationwithtreatmentmodalities
AT sidyukea activityofthymidilatesalvagepathwayenzymesinhumangastriccancerandbloodserumcorrelationwithtreatmentmodalities
AT popovichay activityofthymidilatesalvagepathwayenzymesinhumangastriccancerandbloodserumcorrelationwithtreatmentmodalities
first_indexed 2025-11-28T18:42:43Z
last_indexed 2025-11-28T18:42:43Z
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