Clinical implications of p53 alterations in oral cancer progression: a review from India

• Published in: Experimental Oncology
• Date: 2018
• Main Authors: Patel, K.R., Vajaria, B.N., Singh, R.D., Begum, R., Patel, P.S.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2018
• Subjects: Reviews
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/139242
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Clinical implications of p53 alterations in oral cancer progression: a review from India / K.R. Patel, B.N. Vajaria, R.D. Singh, R. Begum, P.S. Patel // Experimental Oncology. — 2018 — Т. 40, № 1. — С. 10–18. — Бібліогр.: 90 назв. — англ.

p53 plays a central role in prevention of normal cell from the development of the malignant phenotype. Somatic alterations (mutations, loss of heterozygosity, deletions) in p53 are a hallmark of most human cancers and cause defects in normal p53 function. However, in the tumors harboring wild-type p...