Sensitivity to 4-hydroxyestradiol and dna repair efficiency in peripheral blood lymphocytes of endometrial cancer patients

• Published in: Experimental Oncology
• Date: 2018
• Main Authors: Buchynska, L.G., Brieieva, O.V.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2018
• Subjects: Original contributions
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/139243
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Sensitivity to 4-hydroxyestradiol and dna repair efficiency in peripheral blood lymphocytes of endometrial cancer patients / L.G. Buchynska, O.V. Brieieva // Experimental Oncology. — 2018 — Т. 40, № 1. — С. 68–72. — Бібліогр.: 28 назв. — англ.

Background: The development of hormone-dependent cancers, including endometrial carcinomas, in great part may be mediated by the genotoxic effects of estrogen metabolites, among which 4-hydroxyestradiol (4OHE2) is characterized by the most prominent DNA-damaging properties. It is assumed that the in...