Role of components of microRNA machinery in carcinogenesis
MicroRNAs (miRNAs) are a broad class of non-coding RNAs nearly 21 nucleotides length, which play crucial functions in posttranscriptional gene regulation. These molecules are associated with many developmental and cellular processes in eukaryotic organisms. Current investigation has reported major f...
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| Published in: | Experimental Oncology |
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| Date: | 2018 |
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2018
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/139254 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Role of components of microRNA machinery in carcinogenesis / R. Kian, S. Moradi, S. Ghorbian // Experimental Oncology. — 2018 — Т. 40, № 1. — С. 2–9. — Бібліогр.: 97 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862589617604132864 |
|---|---|
| author | Kian, R. Moradi, S. Ghorbian, S. |
| author_facet | Kian, R. Moradi, S. Ghorbian, S. |
| citation_txt | Role of components of microRNA machinery in carcinogenesis / R. Kian, S. Moradi, S. Ghorbian // Experimental Oncology. — 2018 — Т. 40, № 1. — С. 2–9. — Бібліогр.: 97 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | MicroRNAs (miRNAs) are a broad class of non-coding RNAs nearly 21 nucleotides length, which play crucial functions in posttranscriptional gene regulation. These molecules are associated with many developmental and cellular processes in eukaryotic organisms. Current investigation has reported major factors contributing to miRNA biogenesis and has constituted basic principles of miRNA function. More recently, it was confirmed that various miRNAs are clearly implicated in human malignancies, such as lung, breast, ovarian, bladder, colon cancer and other kinds of carcinoma. In addition, dysregulation in the miRNA machinery elements such as Dicer, Drosha, DGCR8, Argonaut, and TRBP could be involved in the progress of many tumor types. The purpose of the current review was to compile growing information besides how miRNA biogenesis and gene silencing are modified to develop cancer.
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| first_indexed | 2025-11-27T03:14:06Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-139254 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-11-27T03:14:06Z |
| publishDate | 2018 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Kian, R. Moradi, S. Ghorbian, S. 2018-06-19T21:13:51Z 2018-06-19T21:13:51Z 2018 Role of components of microRNA machinery in carcinogenesis / R. Kian, S. Moradi, S. Ghorbian // Experimental Oncology. — 2018 — Т. 40, № 1. — С. 2–9. — Бібліогр.: 97 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/139254 MicroRNAs (miRNAs) are a broad class of non-coding RNAs nearly 21 nucleotides length, which play crucial functions in posttranscriptional gene regulation. These molecules are associated with many developmental and cellular processes in eukaryotic organisms. Current investigation has reported major factors contributing to miRNA biogenesis and has constituted basic principles of miRNA function. More recently, it was confirmed that various miRNAs are clearly implicated in human malignancies, such as lung, breast, ovarian, bladder, colon cancer and other kinds of carcinoma. In addition, dysregulation in the miRNA machinery elements such as Dicer, Drosha, DGCR8, Argonaut, and TRBP could be involved in the progress of many tumor types. The purpose of the current review was to compile growing information besides how miRNA biogenesis and gene silencing are modified to develop cancer. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Reviews Role of components of microRNA machinery in carcinogenesis Article published earlier |
| spellingShingle | Role of components of microRNA machinery in carcinogenesis Kian, R. Moradi, S. Ghorbian, S. Reviews |
| title | Role of components of microRNA machinery in carcinogenesis |
| title_full | Role of components of microRNA machinery in carcinogenesis |
| title_fullStr | Role of components of microRNA machinery in carcinogenesis |
| title_full_unstemmed | Role of components of microRNA machinery in carcinogenesis |
| title_short | Role of components of microRNA machinery in carcinogenesis |
| title_sort | role of components of microrna machinery in carcinogenesis |
| topic | Reviews |
| topic_facet | Reviews |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/139254 |
| work_keys_str_mv | AT kianr roleofcomponentsofmicrornamachineryincarcinogenesis AT moradis roleofcomponentsofmicrornamachineryincarcinogenesis AT ghorbians roleofcomponentsofmicrornamachineryincarcinogenesis |