Sensitivity of human laryngeal squamous cell carcinoma Hep-2 to metrotexate chemoterapy

• Published in: Experimental Oncology
• Date: 2012
• Main Authors: Galbiatti, A.L.S., Caldas, H.C., Padovani Junior, J.A., Pavarino, E.C., Goloni-Bertollo, E.M.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2012
• Subjects: Short communications
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/139856
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Sensitivity of human laryngeal squamous cell carcinoma Hep-2 to metrotexate chemoterapy / A.L.S. Galbiatti, H.C. Caldas, J.A. Padovani Junior, E.C. Pavarino, E.M. Goloni-Bertollo // Experimental Oncology. — 2012. — Т. 34, № 4. — С. 367-369. — Бібліогр.: 22 назв. — англ.

Aim: Methotrexate (MTX) is an antifolate agent that acts inhibiting purine and pyrimidine synthesis. The objective of the study was to evaluate the viability of Hep-2 human laryngeal cancer cells to the treatment with MTX chemotherapy in vitro. Methods: Cultured Hep-2 cells were treated with 0.25, 2...