Theoretical ground for adsorptive therapy of anthracyclines cardiotoxicity
Anthracyclines play an important role in treatment of variety types of cancer due to their high effectiveness and broad spectrum of activity. However, a major limitation of their use is the dose-limiting cardiotoxicity. The inability to predict and prevent anthracycline cardiotoxicity is in part due...
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| Published in: | Experimental Oncology |
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| Date: | 2012 |
| ISSN: | 1812-9269 |
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Published: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2012
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| Subjects: | |
| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/139865 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Theoretical ground for adsorptive therapy of anthracyclines cardiotoxicity / O.O. Shevchuk, E.A. Posokhova, L.A. Sakhno, V.G. Nikolaev // Experimental Oncology. — 2012. — Т. 34, № 4. — С. 314-322. — Бібліогр.: 132 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| Summary: | Anthracyclines play an important role in treatment of variety types of cancer due to their high effectiveness and broad spectrum of activity. However, a major limitation of their use is the dose-limiting cardiotoxicity. The inability to predict and prevent anthracycline cardiotoxicity is in part due to the fact that the molecular and cellular mechanisms remain controversial and incompletely understood. This review focuses on the biochemical basis of the anthracyclines toxic cardiac effects and pharmacological measures to their treatment and preventing. We describe the theoretical substantiation of the enterosorption abilities for diminishing of cardiac damage.
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| ISSN: | 1812-9269 |