Effects of combined sonodynamic and photodynamic therapies with photolon on a glioma C6 tumor model
The aim of this study was to investigate the low-power density sonication, sonodynamic therapy (SDT) with Photolon and combination of SDT and photodynamic therapy (PDT) with Photolon for the ablation of glioma C6 tumor model in rats. Methods: The study was performed on 50 rats bearing glioma C6. The...
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| Published in: | Experimental Oncology |
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| Date: | 2012 |
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2012
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/139874 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Effects of combined sonodynamic and photodynamic therapies with photolon on a glioma C6 tumor model / D.A. Tserkovsky, E.N. Alexandrova, V.N. Chalau, Yu.Р. Istomin // Experimental Oncology. — 2012. — Т. 34, № 4. — С. 332-335. — Бібліогр.: 16 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862595454350393344 |
|---|---|
| author | Tserkovsky, D.A. Alexandrova, E.N. Chalau, V.N. Istomin, Yu.P. |
| author_facet | Tserkovsky, D.A. Alexandrova, E.N. Chalau, V.N. Istomin, Yu.P. |
| citation_txt | Effects of combined sonodynamic and photodynamic therapies with photolon on a glioma C6 tumor model / D.A. Tserkovsky, E.N. Alexandrova, V.N. Chalau, Yu.Р. Istomin // Experimental Oncology. — 2012. — Т. 34, № 4. — С. 332-335. — Бібліогр.: 16 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | The aim of this study was to investigate the low-power density sonication, sonodynamic therapy (SDT) with Photolon and combination of SDT and photodynamic therapy (PDT) with Photolon for the ablation of glioma C6 tumor model in rats. Methods: The study was performed on 50 rats bearing glioma C6. The tumors were sonicated with/without prior intravenous injection of photosensitizer (PS) Photolon (2.5 mg/kg b.w). Sonication was performed with 0.4; 0.7 and 1.0 W/cm² power density at 1 MHz frequency for 10 min, 2.0 h after Photolon administration using BTL-5710 Sono (BTL Industries Limited, Great Britain). PDT was carried out 2.5 h after Photolon administration using diode laser with 661 nm wavelength (IMAF-AXICON, Minsk, Republic of Belarus) at doses of 50 and 100 J/cm² with 0,17 W/cm² fluence rate. Assessment of tumor response was performed by vital staining with Evans blue and pathologic examination. Results: The maximal tumor necrosis area that underwent sonication (1 MHz; 0.7 W/cm²; 10 min.) followed by PDT at a dose of 100 J/cm² was 100%. Conclusion: This is the first report to demonstrate the benefits of sono-photodynamic therapy (SPDT) consisting of low-power density ultrasound and PDT for the treatment of malignant glioma models.
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| first_indexed | 2025-11-27T14:21:30Z |
| format | Article |
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| id | nasplib_isofts_kiev_ua-123456789-139874 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-11-27T14:21:30Z |
| publishDate | 2012 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
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| spelling | Tserkovsky, D.A. Alexandrova, E.N. Chalau, V.N. Istomin, Yu.P. 2018-06-21T12:55:56Z 2018-06-21T12:55:56Z 2012 Effects of combined sonodynamic and photodynamic therapies with photolon on a glioma C6 tumor model / D.A. Tserkovsky, E.N. Alexandrova, V.N. Chalau, Yu.Р. Istomin // Experimental Oncology. — 2012. — Т. 34, № 4. — С. 332-335. — Бібліогр.: 16 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/139874 The aim of this study was to investigate the low-power density sonication, sonodynamic therapy (SDT) with Photolon and combination of SDT and photodynamic therapy (PDT) with Photolon for the ablation of glioma C6 tumor model in rats. Methods: The study was performed on 50 rats bearing glioma C6. The tumors were sonicated with/without prior intravenous injection of photosensitizer (PS) Photolon (2.5 mg/kg b.w). Sonication was performed with 0.4; 0.7 and 1.0 W/cm² power density at 1 MHz frequency for 10 min, 2.0 h after Photolon administration using BTL-5710 Sono (BTL Industries Limited, Great Britain). PDT was carried out 2.5 h after Photolon administration using diode laser with 661 nm wavelength (IMAF-AXICON, Minsk, Republic of Belarus) at doses of 50 and 100 J/cm² with 0,17 W/cm² fluence rate. Assessment of tumor response was performed by vital staining with Evans blue and pathologic examination. Results: The maximal tumor necrosis area that underwent sonication (1 MHz; 0.7 W/cm²; 10 min.) followed by PDT at a dose of 100 J/cm² was 100%. Conclusion: This is the first report to demonstrate the benefits of sono-photodynamic therapy (SPDT) consisting of low-power density ultrasound and PDT for the treatment of malignant glioma models. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Effects of combined sonodynamic and photodynamic therapies with photolon on a glioma C6 tumor model Article published earlier |
| spellingShingle | Effects of combined sonodynamic and photodynamic therapies with photolon on a glioma C6 tumor model Tserkovsky, D.A. Alexandrova, E.N. Chalau, V.N. Istomin, Yu.P. Original contributions |
| title | Effects of combined sonodynamic and photodynamic therapies with photolon on a glioma C6 tumor model |
| title_full | Effects of combined sonodynamic and photodynamic therapies with photolon on a glioma C6 tumor model |
| title_fullStr | Effects of combined sonodynamic and photodynamic therapies with photolon on a glioma C6 tumor model |
| title_full_unstemmed | Effects of combined sonodynamic and photodynamic therapies with photolon on a glioma C6 tumor model |
| title_short | Effects of combined sonodynamic and photodynamic therapies with photolon on a glioma C6 tumor model |
| title_sort | effects of combined sonodynamic and photodynamic therapies with photolon on a glioma c6 tumor model |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/139874 |
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