Relationship between NF-κB, ER, PR, Her2/neu, Ki67, p53 expression in human breast cancer

• Published in: Experimental Oncology
• Date: 2012
• Main Authors: Shapochka, D.O., Zaletok, S.P., Gnidyuk, M.I.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2012
• Subjects: Original contributions
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/139879
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Relationship between NF-κB, ER, PR, Her2/neu, Ki67, p53 expression in human breast cancer / D.O. Shapochka, S.P. Zaletok, M.I. Gnidyuk // Experimental Oncology. — 2012. — Т. 34, № 4. — С. 358-363. — Бібліогр.: 38 назв. — англ.

Aim: The aim of the present study was to investigate expression patterns of transcription factor NF-κB (p50 and p65), ER, PR, Her2/neu, Ki-67 and p53 in tumor tissue of patients with breast cancer (BC) and analyze correlation between these markers. Patients and Methods: 62 BC patients previously nottreated with chemo- or radiotherapy were included in the study. All tumors belong to invasive ductal carcinoma of different grade. Expression of molecular markers was determined by immunohistochemical analysis on paraffin-embedded tissue sections. Results: The correlation between tumor grade and expression of ER, PR, Ki-67 and p53 was defined. NF-κB expression was found to be changed dependent on expression of ER, PR and p53 and also on molecular subtype (luminal, Her2-positive, hybrid, basal-like). The highest levels of NF-κB, Ki-67 and p53 were found in Her2/neu+ and basal-like tumor subtypes. Conclusion: The increase of nuclear expression of NF-κB correlates with a decrease of expression of steroid hormone receptors (ER and PR), increase of p53 accumulation, and is associated with Her2-positive and basal-like tumor types.