Relationship between NF-κB, ER, PR, Her2/neu, Ki67, p53 expression in human breast cancer
Aim: The aim of the present study was to investigate expression patterns of transcription factor NF-κB (p50 and p65), ER, PR, Her2/neu, Ki-67 and p53 in tumor tissue of patients with breast cancer (BC) and analyze correlation between these markers. Patients and Methods: 62 BC patients previously not...
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| Опубліковано в: : | Experimental Oncology |
|---|---|
| Дата: | 2012 |
| Автори: | , , |
| Формат: | Стаття |
| Мова: | Англійська |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2012
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| Онлайн доступ: | https://nasplib.isofts.kiev.ua/handle/123456789/139879 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Relationship between NF-κB, ER, PR, Her2/neu, Ki67, p53 expression in human breast cancer / D.O. Shapochka, S.P. Zaletok, M.I. Gnidyuk // Experimental Oncology. — 2012. — Т. 34, № 4. — С. 358-363. — Бібліогр.: 38 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862543124331495424 |
|---|---|
| author | Shapochka, D.O. Zaletok, S.P. Gnidyuk, M.I. |
| author_facet | Shapochka, D.O. Zaletok, S.P. Gnidyuk, M.I. |
| citation_txt | Relationship between NF-κB, ER, PR, Her2/neu, Ki67, p53 expression in human breast cancer / D.O. Shapochka, S.P. Zaletok, M.I. Gnidyuk // Experimental Oncology. — 2012. — Т. 34, № 4. — С. 358-363. — Бібліогр.: 38 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Aim: The aim of the present study was to investigate expression patterns of transcription factor NF-κB (p50 and p65), ER, PR, Her2/neu, Ki-67 and p53 in tumor tissue of patients with breast cancer (BC) and analyze correlation between these markers. Patients and Methods: 62 BC patients previously nottreated with chemo- or radiotherapy were included in the study. All tumors belong to invasive ductal carcinoma of different grade. Expression of molecular markers was determined by immunohistochemical analysis on paraffin-embedded tissue sections. Results: The correlation between tumor grade and expression of ER, PR, Ki-67 and p53 was defined. NF-κB expression was found to be changed dependent on expression of ER, PR and p53 and also on molecular subtype (luminal, Her2-positive, hybrid, basal-like). The highest levels of NF-κB, Ki-67 and p53 were found in Her2/neu+ and basal-like tumor subtypes. Conclusion: The increase of nuclear expression of NF-κB correlates with a decrease of expression of steroid hormone receptors (ER and PR), increase of p53 accumulation, and is associated with Her2-positive and basal-like tumor types.
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| first_indexed | 2025-11-24T20:29:35Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-139879 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-11-24T20:29:35Z |
| publishDate | 2012 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Shapochka, D.O. Zaletok, S.P. Gnidyuk, M.I. 2018-06-21T13:00:16Z 2018-06-21T13:00:16Z 2012 Relationship between NF-κB, ER, PR, Her2/neu, Ki67, p53 expression in human breast cancer / D.O. Shapochka, S.P. Zaletok, M.I. Gnidyuk // Experimental Oncology. — 2012. — Т. 34, № 4. — С. 358-363. — Бібліогр.: 38 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/139879 Aim: The aim of the present study was to investigate expression patterns of transcription factor NF-κB (p50 and p65), ER, PR, Her2/neu, Ki-67 and p53 in tumor tissue of patients with breast cancer (BC) and analyze correlation between these markers. Patients and Methods: 62 BC patients previously nottreated with chemo- or radiotherapy were included in the study. All tumors belong to invasive ductal carcinoma of different grade. Expression of molecular markers was determined by immunohistochemical analysis on paraffin-embedded tissue sections. Results: The correlation between tumor grade and expression of ER, PR, Ki-67 and p53 was defined. NF-κB expression was found to be changed dependent on expression of ER, PR and p53 and also on molecular subtype (luminal, Her2-positive, hybrid, basal-like). The highest levels of NF-κB, Ki-67 and p53 were found in Her2/neu+ and basal-like tumor subtypes. Conclusion: The increase of nuclear expression of NF-κB correlates with a decrease of expression of steroid hormone receptors (ER and PR), increase of p53 accumulation, and is associated with Her2-positive and basal-like tumor types. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Relationship between NF-κB, ER, PR, Her2/neu, Ki67, p53 expression in human breast cancer Article published earlier |
| spellingShingle | Relationship between NF-κB, ER, PR, Her2/neu, Ki67, p53 expression in human breast cancer Shapochka, D.O. Zaletok, S.P. Gnidyuk, M.I. Original contributions |
| title | Relationship between NF-κB, ER, PR, Her2/neu, Ki67, p53 expression in human breast cancer |
| title_full | Relationship between NF-κB, ER, PR, Her2/neu, Ki67, p53 expression in human breast cancer |
| title_fullStr | Relationship between NF-κB, ER, PR, Her2/neu, Ki67, p53 expression in human breast cancer |
| title_full_unstemmed | Relationship between NF-κB, ER, PR, Her2/neu, Ki67, p53 expression in human breast cancer |
| title_short | Relationship between NF-κB, ER, PR, Her2/neu, Ki67, p53 expression in human breast cancer |
| title_sort | relationship between nf-κb, er, pr, her2/neu, ki67, p53 expression in human breast cancer |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/139879 |
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