Zinc differentially modulates DNA damage induced by anthracyclines in normal and cancer cells
Zinc is one of the most essential trace elements in human organism. Low blood level of zinc is often noted in acute lymphocytic leukemia (ALL). Treatment with zinc adjuvant is hypothesized to accelerate recovery from ALL, and in conjunction with chemotherapy, cure ALL. Aim: We determined the effect...
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| Published in: | Experimental Oncology |
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| Date: | 2012 |
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2012
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/139900 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Zinc differentially modulates DNA damage induced by anthracyclines in normal and cancer cells / D. Wysokinski, J. Blasiak, K. Wozniak // Experimental Oncology. — 2012. — Т. 34, № 4. — С. 327-331. — Бібліогр.: 31 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862626146859876352 |
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| author | Wysokinski, D. Blasiak, J. Wozniak, K. |
| author_facet | Wysokinski, D. Blasiak, J. Wozniak, K. |
| citation_txt | Zinc differentially modulates DNA damage induced by anthracyclines in normal and cancer cells / D. Wysokinski, J. Blasiak, K. Wozniak // Experimental Oncology. — 2012. — Т. 34, № 4. — С. 327-331. — Бібліогр.: 31 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Zinc is one of the most essential trace elements in human organism. Low blood level of zinc is often noted in acute lymphocytic leukemia (ALL). Treatment with zinc adjuvant is hypothesized to accelerate recovery from ALL, and in conjunction with chemotherapy, cure ALL. Aim: We determined the effect of zinc on DNA damage induced by doxorubicin and idarubicin, two anthracyclines used in ALL treatment. Methods: The experiment was performed on acute lymphoblastic leukemia cell line (CCRF-CEM) and lymphocytes from peripheral blood of healthy, adult subjects. To evaluate the level of DNA damage the comet assay in the alkaline version was used. Results: We observed a significant difference in DNA damage level between normal and cancer cells in the presence of zinc. Cancer cells exhibited a significant increase of DNA damage in the presence of zinc, while in lymphocytes no such effect was observed. Conclusion: Our results suggest that zinc may protect normal cells against DNA-damaging action of anthracyclins and increase this action in cancer cells.
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| first_indexed | 2025-12-07T13:36:43Z |
| format | Article |
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| id | nasplib_isofts_kiev_ua-123456789-139900 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-07T13:36:43Z |
| publishDate | 2012 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
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| spelling | Wysokinski, D. Blasiak, J. Wozniak, K. 2018-06-21T13:21:11Z 2018-06-21T13:21:11Z 2012 Zinc differentially modulates DNA damage induced by anthracyclines in normal and cancer cells / D. Wysokinski, J. Blasiak, K. Wozniak // Experimental Oncology. — 2012. — Т. 34, № 4. — С. 327-331. — Бібліогр.: 31 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/139900 Zinc is one of the most essential trace elements in human organism. Low blood level of zinc is often noted in acute lymphocytic leukemia (ALL). Treatment with zinc adjuvant is hypothesized to accelerate recovery from ALL, and in conjunction with chemotherapy, cure ALL. Aim: We determined the effect of zinc on DNA damage induced by doxorubicin and idarubicin, two anthracyclines used in ALL treatment. Methods: The experiment was performed on acute lymphoblastic leukemia cell line (CCRF-CEM) and lymphocytes from peripheral blood of healthy, adult subjects. To evaluate the level of DNA damage the comet assay in the alkaline version was used. Results: We observed a significant difference in DNA damage level between normal and cancer cells in the presence of zinc. Cancer cells exhibited a significant increase of DNA damage in the presence of zinc, while in lymphocytes no such effect was observed. Conclusion: Our results suggest that zinc may protect normal cells against DNA-damaging action of anthracyclins and increase this action in cancer cells. The authors thank Malgorzata Stanczyk from Univeristy
 of Lodz for helping in the maintaining of CCRFCEM
 cell line. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Zinc differentially modulates DNA damage induced by anthracyclines in normal and cancer cells Article published earlier |
| spellingShingle | Zinc differentially modulates DNA damage induced by anthracyclines in normal and cancer cells Wysokinski, D. Blasiak, J. Wozniak, K. Original contributions |
| title | Zinc differentially modulates DNA damage induced by anthracyclines in normal and cancer cells |
| title_full | Zinc differentially modulates DNA damage induced by anthracyclines in normal and cancer cells |
| title_fullStr | Zinc differentially modulates DNA damage induced by anthracyclines in normal and cancer cells |
| title_full_unstemmed | Zinc differentially modulates DNA damage induced by anthracyclines in normal and cancer cells |
| title_short | Zinc differentially modulates DNA damage induced by anthracyclines in normal and cancer cells |
| title_sort | zinc differentially modulates dna damage induced by anthracyclines in normal and cancer cells |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/139900 |
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