Down-regulation of murine beta-defensin-2 in Lewis lung carcinoma cells results in accelerated growth of tumor cells in vitro and in vivo

• Published in: Experimental Oncology
• Date: 2008
• Main Authors: Zhuravel, E., Shestakova, T., Glushko, N., Soldatkina, M., Pogrebnoy, P.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2008
• Subjects: Uncategorized
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/139913
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Down-regulation of murine beta-defensin-2 in Lewis lung carcinoma cells results in accelerated growth of tumor cells in vitro and in vivo / E. Zhuravel, T. Shestakova, N. Glushko, M. Soldatkina, P. Pogrebnoy // Experimental Oncology. — 2008. — Т. 30, № 3. — С. 206–211. — Бібліогр.: 21 назв. — англ.

To evaluate the anti-tumor activity of murine beta-defensin-2 (mBD-2) expression in vitro and in vivo. Materials and Methods: Based on pcDNA3 vector, constructs containing mBD-2 cDNA coding mature defensin molecule (pcDNA3-mBD2), and Igk-mBD-2 insertion, coding secretory sequence plus mature defensi...