Alterations of constitutive pericentromeric heterochromatin in lymphocytes of cancer patients and lymphocytes exposed to 5-azacytidine is associated with DNA-hypomethylation

• Published in: Experimental Oncology
• Date: 2008
• Main Author: Shvachko, L.P.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2008
• Subjects: Uncategorized
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/139916
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Alterations of constitutive pericentromeric heterochromatin in lymphocytes of cancer patients and lymphocytes exposed to 5-azacytidine is associated with DNA-hypomethylation / L.P. Shvachko // Experimental Oncology. — 2008. — Т. 30, № 3. — С. 230–234. — Бібліогр.: 28 назв. — англ.

DNA hypomethylation plays a key role in carcinogenesis. The malignant transformation of cells as well as tumor progression is accompanied with increasing DNA hypomethylation in cancer cells. Nevertheless, the evolution of dis-epigenetic genomic alteration in the somatic cellular malignant transforma...