Expression of cancer-associated genes in prostate tumors
Background: Prostate cancer is one of the most common male cancers in Western countries and takes the third place in morbidity
 in Ukraine. It is a highly heterogeneous disease. Aim: To analyze relative expression levels of the TGFB1, IL1B, FOS, EFNA5, TAGLN,
 PLAU, and EPDR1 genes i...
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| Published in: | Experimental Oncology |
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| Date: | 2017 |
| Main Authors: | , , , , , , , , , |
| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2017
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/140088 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Expression of cancer-associated genes in prostate tumors / E.E. Rosenberg, G.V. Gerashchenko, N.V. Hryshchenko, L.V. Mevs, K.A. Nekrasov, R.A. Lytvynenko, Y.V. Vitruk, O.P. Gryzodub, E.A. Stakhovsky, V.I. Kashuba // Experimental Oncology. — 2017 — Т. 39, № 2. — С. 131-137. — Бібліогр.: 36 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862707703138222080 |
|---|---|
| author | Rosenberg, E.E. Gerashchenko, G.V. Hryshchenko, N.V. Mevs, L.V. Nekrasov, K.A. Lytvynenko, R.A. Vitruk, Y.V. Gryzodub, O.P. Stakhovsky, E.A. Kashuba, V.I. |
| author_facet | Rosenberg, E.E. Gerashchenko, G.V. Hryshchenko, N.V. Mevs, L.V. Nekrasov, K.A. Lytvynenko, R.A. Vitruk, Y.V. Gryzodub, O.P. Stakhovsky, E.A. Kashuba, V.I. |
| citation_txt | Expression of cancer-associated genes in prostate tumors / E.E. Rosenberg, G.V. Gerashchenko, N.V. Hryshchenko, L.V. Mevs, K.A. Nekrasov, R.A. Lytvynenko, Y.V. Vitruk, O.P. Gryzodub, E.A. Stakhovsky, V.I. Kashuba // Experimental Oncology. — 2017 — Т. 39, № 2. — С. 131-137. — Бібліогр.: 36 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Background: Prostate cancer is one of the most common male cancers in Western countries and takes the third place in morbidity
in Ukraine. It is a highly heterogeneous disease. Aim: To analyze relative expression levels of the TGFB1, IL1B, FOS, EFNA5, TAGLN,
PLAU, and EPDR1 genes in malignant and non-malignant prostate tissues. Materials and Methods: Total RNA was isolated from
16 prostate adenomas, 37 prostate adenocarcinomas, and 29 conventionally normal prostate tissues. To analyze relative gene expression
levels the quantitative real-time polymerase chain reaction was performed. Results: The significant alterations in the relative
expression levels were found in all analyzed sample groups for 4 genes: FOS, EFNA5, IL1B, and TGFB1. We have found that FOS and
EFNA5 were more frequently overexpressed in carcinomas with Gleason score ≤ 7, compared with adenomas. On contrary, PLAU
expression levels were decreased more frequently in prostate cancers, compared with conventionally normal tissues. Noteworthy,
we found positive correlation between IL1B expression level and PSA (for patients with slight PSA increase, no more than 20.0 ng/ml).
Conclusion: The EFNA5, FOS, IL1B, PLAU, and TGFB1 genes that showed significant expression alterations in prostate tumors,
compared with conventionally normal prostate tissue, may play role in prostate cancer development and should be further investigated.
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| first_indexed | 2025-12-07T17:06:52Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-140088 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-07T17:06:52Z |
| publishDate | 2017 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Rosenberg, E.E. Gerashchenko, G.V. Hryshchenko, N.V. Mevs, L.V. Nekrasov, K.A. Lytvynenko, R.A. Vitruk, Y.V. Gryzodub, O.P. Stakhovsky, E.A. Kashuba, V.I. 2018-06-22T14:06:05Z 2018-06-22T14:06:05Z 2017 Expression of cancer-associated genes in prostate tumors / E.E. Rosenberg, G.V. Gerashchenko, N.V. Hryshchenko, L.V. Mevs, K.A. Nekrasov, R.A. Lytvynenko, Y.V. Vitruk, O.P. Gryzodub, E.A. Stakhovsky, V.I. Kashuba // Experimental Oncology. — 2017 — Т. 39, № 2. — С. 131-137. — Бібліогр.: 36 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/140088 Background: Prostate cancer is one of the most common male cancers in Western countries and takes the third place in morbidity
 in Ukraine. It is a highly heterogeneous disease. Aim: To analyze relative expression levels of the TGFB1, IL1B, FOS, EFNA5, TAGLN,
 PLAU, and EPDR1 genes in malignant and non-malignant prostate tissues. Materials and Methods: Total RNA was isolated from
 16 prostate adenomas, 37 prostate adenocarcinomas, and 29 conventionally normal prostate tissues. To analyze relative gene expression
 levels the quantitative real-time polymerase chain reaction was performed. Results: The significant alterations in the relative
 expression levels were found in all analyzed sample groups for 4 genes: FOS, EFNA5, IL1B, and TGFB1. We have found that FOS and
 EFNA5 were more frequently overexpressed in carcinomas with Gleason score ≤ 7, compared with adenomas. On contrary, PLAU
 expression levels were decreased more frequently in prostate cancers, compared with conventionally normal tissues. Noteworthy,
 we found positive correlation between IL1B expression level and PSA (for patients with slight PSA increase, no more than 20.0 ng/ml).
 Conclusion: The EFNA5, FOS, IL1B, PLAU, and TGFB1 genes that showed significant expression alterations in prostate tumors,
 compared with conventionally normal prostate tissue, may play role in prostate cancer development and should be further investigated. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Expression of cancer-associated genes in prostate tumors Article published earlier |
| spellingShingle | Expression of cancer-associated genes in prostate tumors Rosenberg, E.E. Gerashchenko, G.V. Hryshchenko, N.V. Mevs, L.V. Nekrasov, K.A. Lytvynenko, R.A. Vitruk, Y.V. Gryzodub, O.P. Stakhovsky, E.A. Kashuba, V.I. Original contributions |
| title | Expression of cancer-associated genes in prostate tumors |
| title_full | Expression of cancer-associated genes in prostate tumors |
| title_fullStr | Expression of cancer-associated genes in prostate tumors |
| title_full_unstemmed | Expression of cancer-associated genes in prostate tumors |
| title_short | Expression of cancer-associated genes in prostate tumors |
| title_sort | expression of cancer-associated genes in prostate tumors |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/140088 |
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