Expression of cancer-associated genes in prostate tumors

Expression of cancer-associated genes in prostate tumors

Background: Prostate cancer is one of the most common male cancers in Western countries and takes the third place in morbidity in Ukraine. It is a highly heterogeneous disease. Aim: To analyze relative expression levels of the TGFB1, IL1B, FOS, EFNA5, TAGLN, PLAU, and EPDR1 genes in malignant and...

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Veröffentlicht in:Experimental Oncology
Datum:2017
Hauptverfasser: Rosenberg, E.E., Gerashchenko, G.V., Hryshchenko, N.V., Mevs, L.V., Nekrasov, K.A., Lytvynenko, R.A., Vitruk, Y.V., Gryzodub, O.P., Stakhovsky, E.A., Kashuba, V.I.
Format: Artikel
Sprache:English
Veröffentlicht: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2017
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Online Zugang:https://nasplib.isofts.kiev.ua/handle/123456789/140088
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Zitieren:Expression of cancer-associated genes in prostate tumors / E.E. Rosenberg, G.V. Gerashchenko, N.V. Hryshchenko, L.V. Mevs, K.A. Nekrasov, R.A. Lytvynenko, Y.V. Vitruk, O.P. Gryzodub, E.A. Stakhovsky, V.I. Kashuba // Experimental Oncology. — 2017 — Т. 39, № 2. — С. 131-137. — Бібліогр.: 36 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-140088
record_format dspace
spelling Rosenberg, E.E.
Gerashchenko, G.V.
Hryshchenko, N.V.
Mevs, L.V.
Nekrasov, K.A.
Lytvynenko, R.A.
Vitruk, Y.V.
Gryzodub, O.P.
Stakhovsky, E.A.
Kashuba, V.I.
2018-06-22T14:06:05Z
2018-06-22T14:06:05Z
2017
Expression of cancer-associated genes in prostate tumors / E.E. Rosenberg, G.V. Gerashchenko, N.V. Hryshchenko, L.V. Mevs, K.A. Nekrasov, R.A. Lytvynenko, Y.V. Vitruk, O.P. Gryzodub, E.A. Stakhovsky, V.I. Kashuba // Experimental Oncology. — 2017 — Т. 39, № 2. — С. 131-137. — Бібліогр.: 36 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/140088
Background: Prostate cancer is one of the most common male cancers in Western countries and takes the third place in morbidity in Ukraine. It is a highly heterogeneous disease. Aim: To analyze relative expression levels of the TGFB1, IL1B, FOS, EFNA5, TAGLN, PLAU, and EPDR1 genes in malignant and non-malignant prostate tissues. Materials and Methods: Total RNA was isolated from 16 prostate adenomas, 37 prostate adenocarcinomas, and 29 conventionally normal prostate tissues. To analyze relative gene expression levels the quantitative real-time polymerase chain reaction was performed. Results: The significant alterations in the relative expression levels were found in all analyzed sample groups for 4 genes: FOS, EFNA5, IL1B, and TGFB1. We have found that FOS and EFNA5 were more frequently overexpressed in carcinomas with Gleason score ≤ 7, compared with adenomas. On contrary, PLAU expression levels were decreased more frequently in prostate cancers, compared with conventionally normal tissues. Noteworthy, we found positive correlation between IL1B expression level and PSA (for patients with slight PSA increase, no more than 20.0 ng/ml). Conclusion: The EFNA5, FOS, IL1B, PLAU, and TGFB1 genes that showed significant expression alterations in prostate tumors, compared with conventionally normal prostate tissue, may play role in prostate cancer development and should be further investigated.
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Original contributions
Expression of cancer-associated genes in prostate tumors
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title Expression of cancer-associated genes in prostate tumors
spellingShingle Expression of cancer-associated genes in prostate tumors
Rosenberg, E.E.
Gerashchenko, G.V.
Hryshchenko, N.V.
Mevs, L.V.
Nekrasov, K.A.
Lytvynenko, R.A.
Vitruk, Y.V.
Gryzodub, O.P.
Stakhovsky, E.A.
Kashuba, V.I.
Original contributions
title_short Expression of cancer-associated genes in prostate tumors
title_full Expression of cancer-associated genes in prostate tumors
title_fullStr Expression of cancer-associated genes in prostate tumors
title_full_unstemmed Expression of cancer-associated genes in prostate tumors
title_sort expression of cancer-associated genes in prostate tumors
author Rosenberg, E.E.
Gerashchenko, G.V.
Hryshchenko, N.V.
Mevs, L.V.
Nekrasov, K.A.
Lytvynenko, R.A.
Vitruk, Y.V.
Gryzodub, O.P.
Stakhovsky, E.A.
Kashuba, V.I.
author_facet Rosenberg, E.E.
Gerashchenko, G.V.
Hryshchenko, N.V.
Mevs, L.V.
Nekrasov, K.A.
Lytvynenko, R.A.
Vitruk, Y.V.
Gryzodub, O.P.
Stakhovsky, E.A.
Kashuba, V.I.
topic Original contributions
topic_facet Original contributions
publishDate 2017
language English
container_title Experimental Oncology
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
format Article
description Background: Prostate cancer is one of the most common male cancers in Western countries and takes the third place in morbidity in Ukraine. It is a highly heterogeneous disease. Aim: To analyze relative expression levels of the TGFB1, IL1B, FOS, EFNA5, TAGLN, PLAU, and EPDR1 genes in malignant and non-malignant prostate tissues. Materials and Methods: Total RNA was isolated from 16 prostate adenomas, 37 prostate adenocarcinomas, and 29 conventionally normal prostate tissues. To analyze relative gene expression levels the quantitative real-time polymerase chain reaction was performed. Results: The significant alterations in the relative expression levels were found in all analyzed sample groups for 4 genes: FOS, EFNA5, IL1B, and TGFB1. We have found that FOS and EFNA5 were more frequently overexpressed in carcinomas with Gleason score ≤ 7, compared with adenomas. On contrary, PLAU expression levels were decreased more frequently in prostate cancers, compared with conventionally normal tissues. Noteworthy, we found positive correlation between IL1B expression level and PSA (for patients with slight PSA increase, no more than 20.0 ng/ml). Conclusion: The EFNA5, FOS, IL1B, PLAU, and TGFB1 genes that showed significant expression alterations in prostate tumors, compared with conventionally normal prostate tissue, may play role in prostate cancer development and should be further investigated.
issn 1812-9269
url https://nasplib.isofts.kiev.ua/handle/123456789/140088
citation_txt Expression of cancer-associated genes in prostate tumors / E.E. Rosenberg, G.V. Gerashchenko, N.V. Hryshchenko, L.V. Mevs, K.A. Nekrasov, R.A. Lytvynenko, Y.V. Vitruk, O.P. Gryzodub, E.A. Stakhovsky, V.I. Kashuba // Experimental Oncology. — 2017 — Т. 39, № 2. — С. 131-137. — Бібліогр.: 36 назв. — англ.
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first_indexed 2025-12-07T17:06:52Z
last_indexed 2025-12-07T17:06:52Z
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