miR-608 rs4919510 C>G polymorphism decreased the risk of breast cancer in an Iranian subpopulation
Aim: MicroRNAs (miRNAs) are small noncoding RNAs that function as oncogene or tumor suppressors. The single nucleotide
 polymorphisms in miRNAs potentially can alter miRNA-binding sites on target genes as well as affecting miRNAs expression. The
 present study aimed to evaluate the i...
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| Опубліковано в: : | Experimental Oncology |
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| Дата: | 2016 |
| Автори: | , , , , , , , |
| Формат: | Стаття |
| Мова: | Англійська |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2016
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| Онлайн доступ: | https://nasplib.isofts.kiev.ua/handle/123456789/140089 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | miR-608 rs4919510 C>G polymorphism decreased the risk of breast cancer in an Iranian subpopulation / M. Hashemi, S. Sanaei, M. Rezaei, G. Bahari, S.M. Hashemi, M.A. Mashhadi, M. Taheri,S. Ghavami // Experimental Oncology. — 2016 — Т. 38, № 1. — С. 57-59. — Бібліогр.: 31 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862745810346704896 |
|---|---|
| author | Hashemi, M. Sanaei, S. Rezaei, M. Bahari, G. Hashemi, S.M. Mashhadi, M.A. Taheri, M. Ghavami, S. |
| author_facet | Hashemi, M. Sanaei, S. Rezaei, M. Bahari, G. Hashemi, S.M. Mashhadi, M.A. Taheri, M. Ghavami, S. |
| citation_txt | miR-608 rs4919510 C>G polymorphism decreased the risk of breast cancer in an Iranian subpopulation / M. Hashemi, S. Sanaei, M. Rezaei, G. Bahari, S.M. Hashemi, M.A. Mashhadi, M. Taheri,S. Ghavami // Experimental Oncology. — 2016 — Т. 38, № 1. — С. 57-59. — Бібліогр.: 31 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Aim: MicroRNAs (miRNAs) are small noncoding RNAs that function as oncogene or tumor suppressors. The single nucleotide
polymorphisms in miRNAs potentially can alter miRNA-binding sites on target genes as well as affecting miRNAs expression. The
present study aimed to evaluate the impact of miR-608 rs4919510 C>G variant on breast cancer (BC) risk. Materials and Methods:
This case-control study conducted on 160 women with BC and 192 age-matched healthy women. Genotyping of miR608
rs4919510 was done using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results:
Our findings showed that GC genotype significantly decreased the risk of BC (odds ratio (OR) = 0.49, 95% confidence interval
(CI) 0.28–0.88, p = 0.018) compared to CC genotype. Furthermore the G allele decreased the risk of BC (OR = 0.53,
95%CI 0.30–0.92, p = 0.024). No significant association was found between miR-609 genotypes and clinicopathological characteristics
of BC patients (p > 0.05). Conclusion: Our findings indicate that miR-608 polymorphism might be associated with decreased
risk of BC in an Iranian subpopulation. Further large-scale studies with different ethnicities are needed to verify our findings.
|
| first_indexed | 2025-12-07T20:42:34Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-140089 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-07T20:42:34Z |
| publishDate | 2016 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Hashemi, M. Sanaei, S. Rezaei, M. Bahari, G. Hashemi, S.M. Mashhadi, M.A. Taheri, M. Ghavami, S. 2018-06-22T14:24:59Z 2018-06-22T14:24:59Z 2016 miR-608 rs4919510 C>G polymorphism decreased the risk of breast cancer in an Iranian subpopulation / M. Hashemi, S. Sanaei, M. Rezaei, G. Bahari, S.M. Hashemi, M.A. Mashhadi, M. Taheri,S. Ghavami // Experimental Oncology. — 2016 — Т. 38, № 1. — С. 57-59. — Бібліогр.: 31 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/140089 Aim: MicroRNAs (miRNAs) are small noncoding RNAs that function as oncogene or tumor suppressors. The single nucleotide
 polymorphisms in miRNAs potentially can alter miRNA-binding sites on target genes as well as affecting miRNAs expression. The
 present study aimed to evaluate the impact of miR-608 rs4919510 C>G variant on breast cancer (BC) risk. Materials and Methods:
 This case-control study conducted on 160 women with BC and 192 age-matched healthy women. Genotyping of miR608
 rs4919510 was done using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results:
 Our findings showed that GC genotype significantly decreased the risk of BC (odds ratio (OR) = 0.49, 95% confidence interval
 (CI) 0.28–0.88, p = 0.018) compared to CC genotype. Furthermore the G allele decreased the risk of BC (OR = 0.53,
 95%CI 0.30–0.92, p = 0.024). No significant association was found between miR-609 genotypes and clinicopathological characteristics
 of BC patients (p > 0.05). Conclusion: Our findings indicate that miR-608 polymorphism might be associated with decreased
 risk of BC in an Iranian subpopulation. Further large-scale studies with different ethnicities are needed to verify our findings. This paper was funded by a research grant from the
 Deputy for Research, Zahedan University of Medical
 Sciences. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Short communications miR-608 rs4919510 C>G polymorphism decreased the risk of breast cancer in an Iranian subpopulation Article published earlier |
| spellingShingle | miR-608 rs4919510 C>G polymorphism decreased the risk of breast cancer in an Iranian subpopulation Hashemi, M. Sanaei, S. Rezaei, M. Bahari, G. Hashemi, S.M. Mashhadi, M.A. Taheri, M. Ghavami, S. Short communications |
| title | miR-608 rs4919510 C>G polymorphism decreased the risk of breast cancer in an Iranian subpopulation |
| title_full | miR-608 rs4919510 C>G polymorphism decreased the risk of breast cancer in an Iranian subpopulation |
| title_fullStr | miR-608 rs4919510 C>G polymorphism decreased the risk of breast cancer in an Iranian subpopulation |
| title_full_unstemmed | miR-608 rs4919510 C>G polymorphism decreased the risk of breast cancer in an Iranian subpopulation |
| title_short | miR-608 rs4919510 C>G polymorphism decreased the risk of breast cancer in an Iranian subpopulation |
| title_sort | mir-608 rs4919510 c>g polymorphism decreased the risk of breast cancer in an iranian subpopulation |
| topic | Short communications |
| topic_facet | Short communications |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/140089 |
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