The impact of postoperative complications and implication of a multimodal enhanced recovery programme on long-term outcomes of surgical treatment of colon cancer patients

• Datum: 2015
• Hauptverfasser: Kolesnik, O.O., Lisnyi, I.I., Shudrak, A.A., Lukashenko, A.V., Mahmudov, D.E., Burlaka, A.A.
• Format: Artikel
• Sprache: English
• Veröffentlicht: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2015
• Schriftenreihe: Онкологія
• Schlagworte: Оригинальные исследования
• Online Zugang: https://nasplib.isofts.kiev.ua/handle/123456789/145024
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Zitieren: The impact of postoperative complications and implication of a multimodal enhanced recovery programme on long-term outcomes of surgical treatment of colon cancer patients / O.O. Kolesnik, I.I. Lisnyi, A.A. Shudrak, A.V. Lukashenko, D.E. Mahmudov, A.A. Burlaka // Онкологія. — 2015. — Т. 17, № 2. — С. 102-106. — Бібліогр.: 20 назв. — англ.

Application of the multimodal enhanced recovery program (ERP) proved its effectiveness in surgical treatment of patients with colon cancer. The impact of an ERP on the long-term outcomes remains a challenge. Aim of the study: to assess the impact of an ERP on the long-term outcomes of the surgical treatment of colon cancer patients. Object and methods: a total of 230 patients, who underwent curative surgery for colon cancer from 2008 to 2013, were enrolled and divided into main (130 patients) and control group (100 patients). Results: no significant difference in antropometric data, tumor site, disease stage and surgery type was observed. Grade II–IV according to the Clavien — Dindo classification of surgical complications was determined in 11 (8.5%) patients of main group and in 20 (20.0%) patients of control group (р < 0.05) with postoperative mortality 0.8 and 2.0%, respectively (р < 0.05). Overall 3-year survival differed significantly: 88.4 ± 9.6% — in main and 72.2 ± 7.6% — in control group (р < 0.05) with insignificant shift in disease-free survival — 87.0 ± 7.5% and 90.0 ± 10.2%, respectively (р = 2.235). All patients who had grade II–IV complications didn’t achieve 3-year survival, with the median of 28.7 and 26.2 months (р = 1.954). Conclusion: ERP application leads to the improvement of overall survival by means of reduction of grade II–IV Clavien — Dindo complications.