Ukrain and its emerging role as an antineoplastic agent in systemic malignancies
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| Published in: | Experimental Oncology |
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| Date: | 2013 |
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| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2013
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/145205 |
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| Cite this: | Ukrain and its emerging role as an antineoplastic agent in systemic malignancies / S. Kapoor // Experimental Oncology. — 2013. — Т. 35, № 2. — С. 127. — Бібліогр.: 9 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1859949717028339712 |
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| author | Kapoor S. |
| author_facet | Kapoor S. |
| citation_txt | Ukrain and its emerging role as an antineoplastic agent in systemic malignancies / S. Kapoor // Experimental Oncology. — 2013. — Т. 35, № 2. — С. 127. — Бібліогр.: 9 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| first_indexed | 2025-12-07T16:16:22Z |
| format | Article |
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Experimental Oncology ��� �������� ���� ���ne���� �������� ���� ���ne� ���ne� ���
UKRAIN AND ITS EMERGING ROLE AS AN ANTINEOPLASTIC
AGENT IN SYSTEMIC MALIGNANCIES
S. Kapoor
Mechanicsville, VA
I read with great interest the recent article by Boze
man et al. [�]. Ukrain may inhibit t�mor progression
in a n�mber of other systemic malignancies.
Ukrain mod�lates secreted protein acidic and rich
in cysteine �SPARC� expression in renal cell carcino
mas [�]. As a res�lt it has a negative impact on the
invasiveness of these t�mors. An inhibitory effect
is also seen on matrix metalloproteinase9 expression
in the renal carcinoma cells. In fact� there have been
reports of complete resol�tion of metastatic renal
t�mors following adj�nctive administration of Ukrain
[�]. Similarly� Ukrain atten�ates Bcl� levels and ac
cent�ates Bax levels thereby a�gmenting and pro
moting apoptosis in prostate carcinomas [4]. It also
increases the cleaved PARP levels and a�gments the
expression of FasL. Ukrain also enhances the Thelper
lymphocyte/Ts�ppressor lymphocyte ratio inside the
carcinoma th�s f�rther a�gmenting its antiprolifera
tive activity [�]. Ukrain also enhances apoptosis in the
prostate carcinoma cells as is evident by �preg�lation
of p�� [6]. As a res�lt there is increased acc�m�lation
of carcinomato�s cells in the G�/M phase.
Ukrain administration is accompanied by atten�a
tion of le�cine as well as gl�tamine levels in bladder
carcinomas [�]. Ukrain has a negative impact on trans
port of active free amino acids into the t�mor. As a re
s�lt intrat�moral gl�coneogenesis is atten�ated th�s
decreasing t�mor growth. Ukrain also facilitates s�r
gical interventions s�ch as mastectomy as the mar
gins become more clearly defined. Similarly� Ukrain
a�gments apoptosis in glioblastomas. It mediates
this effect by �preg�lation of “glial fibrillary acidic”
protein f�nction [8]. Ukrain also has a negative impact
on SPARC expression in the glioblastoma cells [9].
The above examples clearly ill�strate the significant
antineoplastic effects of Ukrain on systemic t�mors
and the need for f�rther st�dies in this regard.
REFERENCES
1. Bozeman EN, Srivatsan S, Mohammadi H, et al.
Ukrain, a plant derived semi-synthetic compound, exerts an-
titumor effects against murine and human breast cancer and
induce protective antitumor immunity in mice. Exp Oncol
2012; 34: 340–7.
2. Gagliano N, Pettinari L, Aureli M, et al. Malignant
phenotype of renal cell carcinoma cells is switched by Ukrain
administration in vitro. Anticancer Drugs 2011; 22: 749–62.
3. Prokopchuk OL, Zemskov SV, Susak YM. Ukrain
treatment in a patient with metastatic renal cell carcinoma
extending to the vena cava inferior. Case report. Drugs Exp
Clin Res 2000; 26: 257–9.
4. Venkatesh K, Govindaraj S, Ramachandran A, et al.
Effect of Ukrain on cell survival and apoptosis in the androgen-
independent prostate cancer cell line PC-3. J Environ Pathol
Toxicol Oncol 2011; 30: 11–9.
5. Uglyanitsa KN, Nechiporenko NA, Nefyodov LI, et al.
Results of Ukrain monotherapy of prostate cancer. Drugs Exp
Clin Res 2000; 26: 191–3.
6. Roublevskaia IN, Haake AR, Ludlow JW, Polevo-
da BV. Induced apoptosis in human prostate cancer cell line
LNCaP by Ukrain. Drugs Exp Clin Res 2000; 26: 141–7.
7. Nefyodov LI, Uglyanitsa KN, Nechiporenko NA,
et al. New biochemical mechanisms of the anticancer effect
of Ukrain in the treatment of cancer of the urinary bladder.
Drugs Exp Clin Res 2000; 26: 195–9.
8. Gagliano N, Moscheni C, Torri C, et al. Ukrain modu-
lates glial fibrillary acidic protein, but not connexin 43 expres-
sion, and induces apoptosis in human cultured glioblastoma
cells. Anticancer Drugs 2007; 18: 669–76.
9. Gagliano N, Moscheni C, Torri C, et al. Effect of Ukrain
on matrix metalloproteinase-2 and Secreted Protein Acidic and
Rich in Cysteine (SPARC) expression in human glioblastoma
cells. Anticancer Drugs 2006; 17: 189–94.
Received: May 1, 2013.
Correspondence: E-mail: shailendrakapoor@yahoo.com
Exp Oncol ����
��� �� �������
LETTER TO EDITOR
Copyright © Experimental Oncology, 2013
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| id | nasplib_isofts_kiev_ua-123456789-145205 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-07T16:16:22Z |
| publishDate | 2013 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Kapoor S. 2019-01-19T11:39:31Z 2019-01-19T11:39:31Z 2013 Ukrain and its emerging role as an antineoplastic agent in systemic malignancies / S. Kapoor // Experimental Oncology. — 2013. — Т. 35, № 2. — С. 127. — Бібліогр.: 9 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/145205 en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Letter to editor Ukrain and its emerging role as an antineoplastic agent in systemic malignancies Article published earlier |
| spellingShingle | Ukrain and its emerging role as an antineoplastic agent in systemic malignancies Kapoor S. Letter to editor |
| title | Ukrain and its emerging role as an antineoplastic agent in systemic malignancies |
| title_full | Ukrain and its emerging role as an antineoplastic agent in systemic malignancies |
| title_fullStr | Ukrain and its emerging role as an antineoplastic agent in systemic malignancies |
| title_full_unstemmed | Ukrain and its emerging role as an antineoplastic agent in systemic malignancies |
| title_short | Ukrain and its emerging role as an antineoplastic agent in systemic malignancies |
| title_sort | ukrain and its emerging role as an antineoplastic agent in systemic malignancies |
| topic | Letter to editor |
| topic_facet | Letter to editor |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/145205 |
| work_keys_str_mv | AT kapoors ukrainanditsemergingroleasanantineoplasticagentinsystemicmalignancies |