The level of anti-(GalNAc beta) and anti-para-Forssman disaccharide igg antibodies in patients with gastrointestinal cancer: relation to survival

The level of anti-(GalNAc beta) and anti-para-Forssman disaccharide igg antibodies in patients with gastrointestinal cancer: relation to survival

Serum anti-(GalNAc beta) and anti-para-Forssman disaccharide (PFdi, GalNAc beta1 - 3GalNAc beta) IgG levels were earlier found to be related to histological grading and progression of gastrointestinal cancer. Aim - to study the relation of serum antibodies level to survival in patients with gastroin...

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Published in:Experimental Oncology
Date:2013
Main Authors: Smorodin, E.P., Kurtenkov, O.A., Sergeyev, B.L.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2013
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Online Access:https://nasplib.isofts.kiev.ua/handle/123456789/145210
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Journal Title:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Cite this:The level of anti-(GalNAc beta) and anti-para-Forssman disaccharide igg antibodies in patients with gastrointestinal cancer: relation to survival / E.P. Smorodin, O.A. Kurtenkov, B.L. Sergeyev // Experimental Oncology. — 2013. — Т. 35, № 2. — С. 89-92. — Бібліогр.: 22 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-145210
record_format dspace
spelling Smorodin, E.P.
Kurtenkov, O.A.
Sergeyev, B.L.
2019-01-19T12:15:12Z
2019-01-19T12:15:12Z
2013
The level of anti-(GalNAc beta) and anti-para-Forssman disaccharide igg antibodies in patients with gastrointestinal cancer: relation to survival / E.P. Smorodin, O.A. Kurtenkov, B.L. Sergeyev // Experimental Oncology. — 2013. — Т. 35, № 2. — С. 89-92. — Бібліогр.: 22 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/145210
Serum anti-(GalNAc beta) and anti-para-Forssman disaccharide (PFdi, GalNAc beta1 - 3GalNAc beta) IgG levels were earlier found to be related to histological grading and progression of gastrointestinal cancer. Aim - to study the relation of serum antibodies level to survival in patients with gastrointestinal cancer. Methods: The level of anti-GalNAc beta, and PFdi IgG was analysed in the serum of patients with gastric (n = 78) and colorectal (n = 48) cancers in the long-term follow-up using ELISA with polyacrylamide glycoconjugates. Survival rate and hazard ratio (HR) were assessed by the Kaplan - Meier method and Cox univariate analysis in different pathomorphological groups. Better survival was observed in patients with an increased preoperative level of GalNAc beta antibodies. These were the gastrointestinal group in stages II, III or tumors T2 - 4 (n = 90 - 104, P = 0,007, HR = 0,48 - 0,49, 95 % CI 0,27 - 0,83, and the group with gastric cancer in stages I, II (n = 49, P = 0,051, HR = 0,39, 95 % CI 0,14 - 1,04). The survival time was significantly longer in the gastrointestinal group in patients whose GalNAc beta antibodies level rose in dynamics (stage III or N1 - 2: P = 0,031 - 0,039, HR = 0,29 - 0,31, 95 % CI 0,09 - 1,00). No significant difference in survival of patients was observed in the evaluation of PFdi antibodies. We suggest that the level of antibodies and its change reflect the enteric microbiota colonization, which may influence cancer progression via different interrelations between microbiota, the tumor and immune system. Key Words: gastrointestinal cancer, survival, GalNAc beta and para-Forssman disaccharide antibodies, enteric bacteria.
We are grateful to Dr. A. Lipping for providing histological data, and to R. Syld for correcting English. The study was supported by the Estonian Science Foundation, Grant No 8399.
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Original contributions
The level of anti-(GalNAc beta) and anti-para-Forssman disaccharide igg antibodies in patients with gastrointestinal cancer: relation to survival
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title The level of anti-(GalNAc beta) and anti-para-Forssman disaccharide igg antibodies in patients with gastrointestinal cancer: relation to survival
spellingShingle The level of anti-(GalNAc beta) and anti-para-Forssman disaccharide igg antibodies in patients with gastrointestinal cancer: relation to survival
Smorodin, E.P.
Kurtenkov, O.A.
Sergeyev, B.L.
Original contributions
title_short The level of anti-(GalNAc beta) and anti-para-Forssman disaccharide igg antibodies in patients with gastrointestinal cancer: relation to survival
title_full The level of anti-(GalNAc beta) and anti-para-Forssman disaccharide igg antibodies in patients with gastrointestinal cancer: relation to survival
title_fullStr The level of anti-(GalNAc beta) and anti-para-Forssman disaccharide igg antibodies in patients with gastrointestinal cancer: relation to survival
title_full_unstemmed The level of anti-(GalNAc beta) and anti-para-Forssman disaccharide igg antibodies in patients with gastrointestinal cancer: relation to survival
title_sort level of anti-(galnac beta) and anti-para-forssman disaccharide igg antibodies in patients with gastrointestinal cancer: relation to survival
author Smorodin, E.P.
Kurtenkov, O.A.
Sergeyev, B.L.
author_facet Smorodin, E.P.
Kurtenkov, O.A.
Sergeyev, B.L.
topic Original contributions
topic_facet Original contributions
publishDate 2013
language English
container_title Experimental Oncology
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
format Article
description Serum anti-(GalNAc beta) and anti-para-Forssman disaccharide (PFdi, GalNAc beta1 - 3GalNAc beta) IgG levels were earlier found to be related to histological grading and progression of gastrointestinal cancer. Aim - to study the relation of serum antibodies level to survival in patients with gastrointestinal cancer. Methods: The level of anti-GalNAc beta, and PFdi IgG was analysed in the serum of patients with gastric (n = 78) and colorectal (n = 48) cancers in the long-term follow-up using ELISA with polyacrylamide glycoconjugates. Survival rate and hazard ratio (HR) were assessed by the Kaplan - Meier method and Cox univariate analysis in different pathomorphological groups. Better survival was observed in patients with an increased preoperative level of GalNAc beta antibodies. These were the gastrointestinal group in stages II, III or tumors T2 - 4 (n = 90 - 104, P = 0,007, HR = 0,48 - 0,49, 95 % CI 0,27 - 0,83, and the group with gastric cancer in stages I, II (n = 49, P = 0,051, HR = 0,39, 95 % CI 0,14 - 1,04). The survival time was significantly longer in the gastrointestinal group in patients whose GalNAc beta antibodies level rose in dynamics (stage III or N1 - 2: P = 0,031 - 0,039, HR = 0,29 - 0,31, 95 % CI 0,09 - 1,00). No significant difference in survival of patients was observed in the evaluation of PFdi antibodies. We suggest that the level of antibodies and its change reflect the enteric microbiota colonization, which may influence cancer progression via different interrelations between microbiota, the tumor and immune system. Key Words: gastrointestinal cancer, survival, GalNAc beta and para-Forssman disaccharide antibodies, enteric bacteria.
issn 1812-9269
url https://nasplib.isofts.kiev.ua/handle/123456789/145210
fulltext
citation_txt The level of anti-(GalNAc beta) and anti-para-Forssman disaccharide igg antibodies in patients with gastrointestinal cancer: relation to survival / E.P. Smorodin, O.A. Kurtenkov, B.L. Sergeyev // Experimental Oncology. — 2013. — Т. 35, № 2. — С. 89-92. — Бібліогр.: 22 назв. — англ.
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first_indexed 2025-11-24T11:44:37Z
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