Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development
Aim: The high incidence of gastrointestinal cancer combined with high mortality from the disease if diagnosed at a late stage, signifies the need for better diagnostic, prognostic and predictive tools. Human beta-herpesviruses have been suggested as possible cofactors in the development of gastroint...
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| Veröffentlicht in: | Experimental Oncology |
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| Datum: | 2013 |
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | Englisch |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2013
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| Online Zugang: | https://nasplib.isofts.kiev.ua/handle/123456789/145211 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Zitieren: | Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development / A. Sultanova, M. Chistjakovs, S. Chapenko, S. Donina, M. Murovska // Experimental Oncology. — 2013. — Т. 35, № 2. — С. 93-96. — Бібліогр.: 18 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862702147966074880 |
|---|---|
| author | Sultanova A. Chistjakovs M. Chapenko S. Donina S. Murovska M. |
| author_facet | Sultanova A. Chistjakovs M. Chapenko S. Donina S. Murovska M. |
| citation_txt | Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development / A. Sultanova, M. Chistjakovs, S. Chapenko, S. Donina, M. Murovska // Experimental Oncology. — 2013. — Т. 35, № 2. — С. 93-96. — Бібліогр.: 18 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Aim: The high incidence of gastrointestinal cancer combined with high mortality from the disease if diagnosed at a late stage, signifies the need for better diagnostic, prognostic and predictive tools. Human beta-herpesviruses have been suggested as possible cofactors in the development of gastrointestinal cancer. Methods: Sixty five patients with gastrointestinal cancer before surgery and without any treatment were enrolled in this study and divided into two groups depending on lymphocytes’ count: I group (n = 35) — lymphocytes > 1400x10⁶ /L and II group (n = 30) — lymphocytes < 1400x10⁶ /L. Nested polymerase chain reaction was used to detect latent and active stage of persistent human herpesvirus-6 and -7 infection, laser flow cytometry with monoclonal antibodies — to determine immunological parameters. Results: Activation of herpesvirus-6 and -7 was more frequently observed in the patients’ group with lymphopenia (HHV-6 1/1 (100%), HHV-7 4/8 (50%) and HHV-6 + HHV-7 6/9 (66%); p < 0.05). Cellular immune parameters were analysed in immunocompromised II group’s patients dependently on beta-herpevirus infection. Although number of leukocytes was higher in patients with active HHV-6/-7 infection (p = 0.01), number of lymphocytes CD3⁺, CD4⁺, CD8⁺ and CD38⁺ in patients with active HHV-6/-7 infection tended to decrease (p < 0.0001, P = 0.0002, p = 0.0001 and p < 0.0001, respectively). However, number of CD19+ had tendency to increase (p = 0.03). Conclusion: Activation of herpesvirus-6 and -7 may lead to decrease of lymphocytes total count and develop immunosuppression in patients with gastrointestinal cancer. Key Words: beta-herpesvirus-6, beta-herpesvirus-7, gastrointestinal cancer.
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| first_indexed | 2025-12-07T16:43:51Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-145211 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-07T16:43:51Z |
| publishDate | 2013 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Sultanova A. Chistjakovs M. Chapenko S. Donina S. Murovska M. 2019-01-19T12:27:19Z 2019-01-19T12:27:19Z 2013 Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development / A. Sultanova, M. Chistjakovs, S. Chapenko, S. Donina, M. Murovska // Experimental Oncology. — 2013. — Т. 35, № 2. — С. 93-96. — Бібліогр.: 18 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/145211 Aim: The high incidence of gastrointestinal cancer combined with high mortality from the disease if diagnosed at a late stage, signifies the need for better diagnostic, prognostic and predictive tools. Human beta-herpesviruses have been suggested as possible cofactors in the development of gastrointestinal cancer. Methods: Sixty five patients with gastrointestinal cancer before surgery and without any treatment were enrolled in this study and divided into two groups depending on lymphocytes’ count: I group (n = 35) — lymphocytes > 1400x10⁶ /L and II group (n = 30) — lymphocytes < 1400x10⁶ /L. Nested polymerase chain reaction was used to detect latent and active stage of persistent human herpesvirus-6 and -7 infection, laser flow cytometry with monoclonal antibodies — to determine immunological parameters. Results: Activation of herpesvirus-6 and -7 was more frequently observed in the patients’ group with lymphopenia (HHV-6 1/1 (100%), HHV-7 4/8 (50%) and HHV-6 + HHV-7 6/9 (66%); p < 0.05). Cellular immune parameters were analysed in immunocompromised II group’s patients dependently on beta-herpevirus infection. Although number of leukocytes was higher in patients with active HHV-6/-7 infection (p = 0.01), number of lymphocytes CD3⁺, CD4⁺, CD8⁺ and CD38⁺ in patients with active HHV-6/-7 infection tended to decrease (p < 0.0001, P = 0.0002, p = 0.0001 and p < 0.0001, respectively). However, number of CD19+ had tendency to increase (p = 0.03). Conclusion: Activation of herpesvirus-6 and -7 may lead to decrease of lymphocytes total count and develop immunosuppression in patients with gastrointestinal cancer. Key Words: beta-herpesvirus-6, beta-herpesvirus-7, gastrointestinal cancer. This work was supported partly by the National
 Research Program in Medicine, “Multi-Disciplinary
 Research Consortium on Major Pathologies Threatening
 the Life Expectancy and Quality of life of Latvian
 Population” project № 11. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development Article published earlier |
| spellingShingle | Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development Sultanova A. Chistjakovs M. Chapenko S. Donina S. Murovska M. Original contributions |
| title | Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development |
| title_full | Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development |
| title_fullStr | Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development |
| title_full_unstemmed | Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development |
| title_short | Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development |
| title_sort | possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/145211 |
| work_keys_str_mv | AT sultanovaa possibleinterferenceofhumanbetaherpesviruses6and7ingastrointestinalcancerdevelopment AT chistjakovsm possibleinterferenceofhumanbetaherpesviruses6and7ingastrointestinalcancerdevelopment AT chapenkos possibleinterferenceofhumanbetaherpesviruses6and7ingastrointestinalcancerdevelopment AT doninas possibleinterferenceofhumanbetaherpesviruses6and7ingastrointestinalcancerdevelopment AT murovskam possibleinterferenceofhumanbetaherpesviruses6and7ingastrointestinalcancerdevelopment |