Overview on locally advanced breast cancer: defining, epidemiology, and overview on neoadjuvant therapy
According to the analysis on locally advanced breast cancer (LABC) from all breast cancer cases recorded in Surveillance Epidemiology and End Results database between the years 1992 - 1999 in the United States, the incidence of LABC were found to be 4,6 % of all female breast cancers. Clinically, wh...
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| Published in: | Experimental Oncology |
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| Date: | 2013 |
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| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2013
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/145234 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Overview on locally advanced breast cancer: defining, epidemiology, and overview on neoadjuvant therapy / B. Yalcin // Experimental Oncology. — 2013. — Т. 35, № 4. — С. 250-252. — Бібліогр.: 23 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| id |
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Yalcin, B. 2019-01-19T17:42:43Z 2019-01-19T17:42:43Z 2013 Overview on locally advanced breast cancer: defining, epidemiology, and overview on neoadjuvant therapy / B. Yalcin // Experimental Oncology. — 2013. — Т. 35, № 4. — С. 250-252. — Бібліогр.: 23 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/145234 According to the analysis on locally advanced breast cancer (LABC) from all breast cancer cases recorded in Surveillance Epidemiology and End Results database between the years 1992 - 1999 in the United States, the incidence of LABC were found to be 4,6 % of all female breast cancers. Clinically, when breast cancer has advanced locoregionally but has not yet spread outside of the breast and regional lymph nodes, it is considered LABC. LABC includes breast cancers that have evidence of a large mass, involve the skin of the breast or the underlying muscles of the chest wall, and cancers that have infiltrated into the local lymph nodes. The prognosis of patients with LABC is relatively poor, with 5-year survival rates less than 50 %. Because the incidence of LABC is very low, there are not many studies comparing neoadjuvant chemotherapy regimens in the literature. In management of LABC, initial therapy should be systemic neoadjuvant chemotherapy, aiming pCR. Anthracycline-based chemotherapy regimens are frequently recommended as the standard primary neoadjuvant chemotherapy for the treatment of LABC. Today the optimal duration of neoadjuvant chemotherapy is unknown. Neoadjuvant endocrine therapy is considered an option for patients with honnone receptor-positive LABC. Ongoing clinical trials are now under way to evaluate the use of novel targeted agents in the neoadjuvant treatment of LABC. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Special issue on breast cancer Overview on locally advanced breast cancer: defining, epidemiology, and overview on neoadjuvant therapy Article published earlier |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| title |
Overview on locally advanced breast cancer: defining, epidemiology, and overview on neoadjuvant therapy |
| spellingShingle |
Overview on locally advanced breast cancer: defining, epidemiology, and overview on neoadjuvant therapy Yalcin, B. Special issue on breast cancer |
| title_short |
Overview on locally advanced breast cancer: defining, epidemiology, and overview on neoadjuvant therapy |
| title_full |
Overview on locally advanced breast cancer: defining, epidemiology, and overview on neoadjuvant therapy |
| title_fullStr |
Overview on locally advanced breast cancer: defining, epidemiology, and overview on neoadjuvant therapy |
| title_full_unstemmed |
Overview on locally advanced breast cancer: defining, epidemiology, and overview on neoadjuvant therapy |
| title_sort |
overview on locally advanced breast cancer: defining, epidemiology, and overview on neoadjuvant therapy |
| author |
Yalcin, B. |
| author_facet |
Yalcin, B. |
| topic |
Special issue on breast cancer |
| topic_facet |
Special issue on breast cancer |
| publishDate |
2013 |
| language |
English |
| container_title |
Experimental Oncology |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| format |
Article |
| description |
According to the analysis on locally advanced breast cancer (LABC) from all breast cancer cases recorded in Surveillance Epidemiology and End Results database between the years 1992 - 1999 in the United States, the incidence of LABC were found to be 4,6 % of all female breast cancers. Clinically, when breast cancer has advanced locoregionally but has not yet spread outside of the breast and regional lymph nodes, it is considered LABC. LABC includes breast cancers that have evidence of a large mass, involve the skin of the breast or the underlying muscles of the chest wall, and cancers that have infiltrated into the local lymph nodes. The prognosis of patients with LABC is relatively poor, with 5-year survival rates less than 50 %. Because the incidence of LABC is very low, there are not many studies comparing neoadjuvant chemotherapy regimens in the literature. In management of LABC, initial therapy should be systemic neoadjuvant chemotherapy, aiming pCR. Anthracycline-based chemotherapy regimens are frequently recommended as the standard primary neoadjuvant chemotherapy for the treatment of LABC. Today the optimal duration of neoadjuvant chemotherapy is unknown. Neoadjuvant endocrine therapy is considered an option for patients with honnone receptor-positive LABC. Ongoing clinical trials are now under way to evaluate the use of novel targeted agents in the neoadjuvant treatment of LABC.
|
| issn |
1812-9269 |
| url |
https://nasplib.isofts.kiev.ua/handle/123456789/145234 |
| citation_txt |
Overview on locally advanced breast cancer: defining, epidemiology, and overview on neoadjuvant therapy / B. Yalcin // Experimental Oncology. — 2013. — Т. 35, № 4. — С. 250-252. — Бібліогр.: 23 назв. — англ. |
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AT yalcinb overviewonlocallyadvancedbreastcancerdefiningepidemiologyandoverviewonneoadjuvanttherapy |
| first_indexed |
2025-11-27T22:40:41Z |
| last_indexed |
2025-11-27T22:40:41Z |
| _version_ |
1850852931799089152 |