Role of postmastectomy radiation therapy after neoadjuvant chemotherapy in locally advanced breast cancer

• Published in: Experimental Oncology
• Date: 2013
• ISSN: 1812-9269
• Main Authors: Akyurek, S., Yavas, G
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2013
• Subjects: Special issue on breast cancer
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/145237
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Role of postmastectomy radiation therapy after neoadjuvant chemotherapy in locally advanced breast cancer / S. Akyurek, G. Yavas // Experimental Oncology. — 2013. — Т. 35, № 4. — С. 267-271. — Бібліогр.: 35 назв. — англ.

Neoadjuvant chemotherapy for primary breast cancer is the gold standard in the treatment of locally advanced, inoperable breast cancer, and also based on a large body of evidence has become a standard treatment option for patients with operable disease, who are clear candidates for adjuvant chemotherapy. There are several advantages of administering neoadjuvant chemotherapy: tumor downstaging, improving the chance of breast conserving surgery, in vivo assessment of tumor sensitivity to the chosen therapeutic regimen, and early control of micro-metastatic disease. However there are substantially less data to aid in determining which patients treated with neo-adjuvant chemotherapy warrant postmastectomy radiotherapy. According to the recent literature, patients who require mastectomy after systemic therapy should receive postmastectomy radiotherapy.